Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Threats and Responses |
| Discussion Leader: Manuel A. Navia (Oxford Bioscience Partners, USA) |
7:40 pm - 8:20 pm | Dennis Dixon (National Institute of Allergy and Infectious Diseases, NIH, USA) "Antimicrobial Resistance: The Very Big Picture" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Rick Fairhurst (National Institute of Allergy and Infectious Diseases, NIH, USA) "Global Threat from Artemisinin Resistance in Malaria" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Understanding Resistance |
| Discussion Leader: Lizbeth Hedstrom (Brandeis University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:45 am | Robert Douglas Sammons (The Monsanto Company, USA) "Glyphosate Selects Novel Resistance Mechanisms Not
Seen in Plants" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Ruchi Anand (Indian Institute of Technology Bombay, India) "Structural Insights into Antibiotic Regulation and Resistance in Streptomyces" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:20 am | Martin Burke (University of Illinois at Urbana-Champaign, USA) "Non-Toxic Lipid-Binding Antifungal Combinations" |
11:20 am - 11:35 am | Discussion |
11:35 am - 12:15 pm | Ashley Vaughan (Center for Infectious Disease Research, USA) "Tracking Malaria Drug Resistance Traits in Humanized
Mice" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Paths to Stable Resistance Traits |
| Discussion Leader: Karen Allen (Boston University, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:15 pm | Marc Ouellette (Centre Hospitalier de l'Université Laval, Canada) "Evolution of Drug Resistance in Leishmania" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | David Skurnik (Harvard Medical School, USA) "Higher Fitness and Increased Pathogenicity in
Resistant Organisms" |
9:10 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Avoiding Resistance |
| Discussion Leader: Michael Cynamon (State University of New York Upstate Medical University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:45 am | Ethan Settembre (Seqirus, USA) "Influenza Vaccines for the 21st Century" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Aaron Goldman (Harvard Medical School, USA) "Multidrug Combinations in Cancer" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:20 am | Alejandro Vila (National University of Rosario, Argentina) "Beta-Lactamase Inhibitors: A Renaissance" |
11:20 am - 11:35 am | Discussion |
11:35 am - 12:15 pm | Mariangela Bonizzoni (University of Pavia, Italy) "Control of the Dengue Vectors Aedus aegypti and Aedus albopictus: Challenges of Insecticide Resistance and Alternative Methods" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Advancing Tools and Methods |
| Discussion Leader: Celia Schiffer (University of Massachusetts Medical School, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:15 pm | Harren Jhoti (Astex Pharmaceuticals, United Kingdom) "Fragment-Based Discovery of New Functional Binding
Sites on Proteins" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Sriram Subramaniam (National Cancer Institute, NIH, USA) "Cryo-EM
of Cells, Viruses and Protein Complexes: Tools for Drug Discovery" |
9:10 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Exploiting Existing Resistance |
| Discussion Leader: Juswinder Singh (Ankaa Therapeutics, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:45 am | Skirmantas Kriaucionis (Oxford University, United Kingdom) "Targeting Overexpressed CDA in Cancer Cells" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Stephanie Reeve (University of Connecticut, USA) "Trimethoprim Resistance in Clinically Isolated S. aureus" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:45 am | Coffee Break |
10:45 am - 11:25 am | Margaret Riley (University of Massachusetts Amherst, USA) "Bacteriocins: A Promising
Alternative to Conventional Antibiotics" |
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | SooNee Tan (University of Washington, USA) "Drug Dependent GSK2645947 Resistance in Plasmodium falciparum" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Terence Crofts (Washington University in St. Louis, USA) "Soil Amidases Allow Catabolism of Beta-Lactam Antibiotics by Environmental Bacteria" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Targeting Host Processes |
| Discussion Leader: Mariano Garcia-Blanco (University of Texas Medical Branch at Galveston, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:15 pm | Michael Starnbach (Harvard Medical School, USA) "Genomic Hunt for Host Determinants in Chlamydia Infections" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Alexis Kaushansky (Center for Infectious Disease Research, USA) "Targeting Liver Cell Biochemistry for Malaria
Prophylaxis" |
9:10 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Generalizable Strategies: Combinations, Multi-Targeting, or Privileged Targets |
| Discussion Leader: Pradipsinh Rathod (University of Washington, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:45 am | Didier Leroy (Medicines for Malaria Venture, Switzerland) "Managing the Malaria Drug Resistance Portfolio" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Nese Kurt Yilmaz (University of Massachusetts Medical School, USA) "Improving Inhibitor Design to Counter Resistance: Lessons from HIV-1 and HCV Protease Inhibitors" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:20 am | Michael Cynamon (State University of New York Upstate Medical University, USA) "Future Tuberculosis Therapy from an HIV Perspective" |
11:20 am - 11:35 am | Discussion |
11:35 am - 12:15 pm | Gautam Dantas (Washington University School of Medicine, USA) "Networks Exchanging Antibiotic Resistance" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Connecting Paths to Patients |
| Discussion Leader: Jared Silverman (Kaleido Biosciences, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:15 pm | Keith Jerome (Fred Hutchinson Cancer Research Center, USA) "Towards CRISPR-Based Antiviral Treatments" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | General Discussion |
9:15 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |