Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Reviewing Progress and Setbacks on the Front Lines of Drug Resistance
Discussion Leader: Juswinder Singh (Ankaa Therapeutics, USA)
7:40 pm - 8:20 pm
Vance Fowler (Duke University Medical Center, USA)
"Antibacterial Resistance and the Antibacterial Resistance Leadership Group: Problems, Innovations and Productivity"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Stephen Fawell (AstraZeneca, USA)
"Challenges and Opportunities in Cancer Drug Resistance"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modeling of Resistance
Discussion Leader: Dominik Wodarz (University of California, Irvine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Natalia Komarova (University of California Irvine, USA)
"Stochastic Modeling of Drug Resistance in Cancer"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Bruce Levin (Emory University, USA)
"The Within-Host Pharmaco-Population- and Immune-Dynamics of Antibiotic Treatment and the Evolution of Resistance"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
James Korkola (Oregon Health & Science University, USA)
"Imaging Approaches to Discovery of Microenvironment Mediated Resistance Mechanisms in Cancer"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
Alison Hill (Harvard University, USA)
"Life Cycle Synchronization Is a Viral Drug Resistance Mechanism"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Justin Pritchard (The Pennsylvania State University, USA)
"Nucleotide Mutation Biases Can Drive the Prevalence of Specific Amino Acid Mutations that Confer Drug Resistance"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New and Emerging Drug Resistance Mechanisms
Discussion Leader: Priscilla Yang (Harvard Medical School, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Judith Berman (Tel Aviv University, Israel)
"Clearing the FoG: Quantification and Characterization of Antifungal Tolerance"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Anaïs Aulas (Brigham and Women's Hospital / Harvard Medical School, USA)
"Stress Granules as Potential Biomarkers for Chemotherapy Drug Resistance"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Anil Korkut (University of Texas MD Anderson Cancer Center, USA)
"TargetScore: A Data-Driven Network Biology Algorithm for Overcoming Adaptive Resistance to Cancer Therapy"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tackling Resistance in Discovery and Development for Cancer
Discussion Leader: Aaron Goldman (Harvard Medical School, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Erica Evans (Blueprint Medicines, USA)
"Building Kinase Inhibitor Programs with Resistance in Mind"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Sara Buhrlage (Dana-Farber Cancer Institute, USA)
"Novel Strategies to Induce Degradation of Leukemia Oncogenes"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Trever Bivona (University of California, San Francisco, USA)
"Emerging Principles of Resistance to Targeted Cancer Therapy"
11:35 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Paul Mischel (San Diego Branch, Ludwig Cancer Research / University of California, San Diego, USA)
"In Cancer, as in Real Estate, Location Matters: The Role of Extrachromosomal Oncogene Amplification in Cancer"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tackling Resistance in Discovery and Development for Anti-Infectives
Discussion Leader: Michael Cynamon (VA Medical Center, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Tim van Opijnen (Boston College, USA)
"Predicting Antibiotic Resistance Through Microfluidics, Single Cell-Analysis, Omics-Approaches, Experimental Evolution and Full-Genome Modeling"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Paul Ambrose (Institute for Clinical Pharmacodynamics, Inc., USA)
"Antimicrobial Replication Rate Modulation: Turning the Microbe Against Itself"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Ann Kwong (Trek Therapeutics, USA)
"HCV Is the Only Viral Infection that Can Be Cured – Harbinger of the Future or a Unicorn?"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Approaches to Drug Resistance
Discussion Leader: Neil Dhawan (Fuse Therapeutics, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
John Overington (Medicines Discovery Catapult, United Kingdom)
"Drug Blending as an Approach to Tackling Cancer Resistance"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Jean-Marie Pagès (Aix-Marseille University, France)
"Antibiotic Translocation and Membrane Barrier: New Tools to Dissect the Bacterial Resistance"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Cassandra Quave (Emory University, USA)
"Medical Ethnobotany and the Discovery of New Drugs to Combat Antibiotic Resistance"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ignacio Rodriguez-Brenes (University of California, Irvine, USA)
"Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Rebecca Yeboah (WACCBIP, University of Ghana, Ghana)
"Analysis of Antimicrobial Resistance Phenotypes in Candida albicans Using Modulators of Mdr/Cdr Gene Expression"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jens Rolff (Free University of Berlin, Germany)
"Predicting Drug Resistance Evolution: Antibiotics vs. Antimicrobial Peptide"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Late-Breaking Topics
Discussion Leader: Carolyn Shore (National Academies of Sciences, Engineering, and Medicine, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Jo-Anne Dillon (University of Saskatchewan, Canada)
"How Neisseria gonorrhoeae Emerged as a Superbug: Are Current Strategies to Combat AMR Effective?"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Elizabeth Winzeler (University of California, San Diego, USA)
"Mapping the Malaria Parasite Druggable Genome by Using In Vitro Evolution and Chemogenomics"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Shashank Gupta (Brown University, USA)
"Suppressor Cell-Targeted Immunotherapy with Denileukin Diftitox, a Recombinant Toxin, Improves TB Treatment"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Daniel Charlebois (Stony Brook University, USA)
"Heterogeneity in Mammalian Drug Resistance"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Shannon Coleman (University of British Columbia, Canada)
"Mechanisms of Antibiotic Resistance in Pseudomonas aeruginosa Swarming Motility"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterogeneity
Discussion Leader: Alexis Kaushansky (Center for Infectious Disease Research, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Fred Mast (Center for Infectious Disease Research, USA)
"Network Biology and Infectious Disease"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Andriy Marusyk (Moffitt Cancer Center, USA)
"Intra-Tumor Heterogeneity in Resistance to Targeted Cancer Therapies"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Daruka Mahadevan (University of Arizona Cancer Center, USA)
"Anti-Evolution Therapies for Cancer"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
Grace Anderson (Duke University, USA)
"Drug Resistant Cancers Harbor Collateral Vulnerabilities that Can Be Leveraged to Select Against Resistance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jianmin Gao (Boston College, USA)
"Novel Phage Platforms for Developing Targeted Antibiotics"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Shuyi Ma (Center for Infectious Disease Research, USA)
"Network Stress Tests Reveal Novel Drug Potentiators in Mycobacterium tuberculosis "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Diagnostics
Discussion Leader: Andrew Tomaras (BacterioScan Inc., USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Ellen Foxman (Yale University, USA)
"Host-Response Based Testing in the Diagnosis of Airway Infections"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Shana Kelley (University of Toronto, Canada)
"New Technologies for Rapid Infectious Disease Diagnosis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Jessica Beach (Peter MacCallum Cancer Centre, Australia)
"Elucidating the Role of ABCB1 Transcript Fusions in Chemoresistant Ovarian Cancer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Akos Nyerges (Biological Research Centre, Hungarian Academy of Sciences, Hungary)
"Rapid Exploration of Drug Resistance-Conferring Mutations by Targeted Mutagenesis in Pathogenic Bacteria"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ivan de Jesus Salazar Estrada (Macquarie University, Australia)
"EGFR-Targeted Chemical Proteomics for Elucidating Drug Resistance Mechanisms in Cancer"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure