Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Reviewing Progress and Setbacks on the Front Lines of Drug Resistance
7:40 pm - 8:20 pm
"Antibacterial Resistance and the Antibacterial Resistance Leadership Group: Problems, Innovations and Productivity"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Challenges and Opportunities in Cancer Drug Resistance"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Stochastic Modeling of Drug Resistance in Cancer"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"The Within-Host Pharmaco-Population- and Immune-Dynamics of Antibiotic Treatment and the Evolution of Resistance"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Imaging Approaches to Discovery of Microenvironment Mediated Resistance Mechanisms in Cancer"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Life Cycle Synchronization Is a Viral Drug Resistance Mechanism"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Nucleotide Mutation Biases Can Drive the Prevalence of Specific Amino Acid Mutations that Confer Drug Resistance"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New and Emerging Drug Resistance Mechanisms
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Clearing the FoG: Quantification and Characterization of Antifungal Tolerance"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Stress Granules as Potential Biomarkers for Chemotherapy Drug Resistance"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"TargetScore: A Data-Driven Network Biology Algorithm for Overcoming Adaptive Resistance to Cancer Therapy"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tackling Resistance in Discovery and Development for Cancer
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Building Kinase Inhibitor Programs with Resistance in Mind"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Novel Strategies to Induce Degradation of Leukemia Oncogenes"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Emerging Principles of Resistance to Targeted Cancer Therapy"
11:35 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"In Cancer, as in Real Estate, Location Matters: The Role of Extrachromosomal Oncogene Amplification in Cancer"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tackling Resistance in Discovery and Development for Anti-Infectives
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Predicting Antibiotic Resistance Through Microfluidics, Single Cell-Analysis, Omics-Approaches, Experimental Evolution and Full-Genome Modeling"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Antimicrobial Replication Rate Modulation: Turning the Microbe Against Itself"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"HCV Is the Only Viral Infection that Can Be Cured – Harbinger of the Future or a Unicorn?"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Approaches to Drug Resistance
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Drug Blending as an Approach to Tackling Cancer Resistance"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Antibiotic Translocation and Membrane Barrier: New Tools to Dissect the Bacterial Resistance"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Medical Ethnobotany and the Discovery of New Drugs to Combat Antibiotic Resistance"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Analysis of Antimicrobial Resistance Phenotypes in Candida albicans Using Modulators of Mdr/Cdr Gene Expression"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Predicting Drug Resistance Evolution: Antibiotics vs. Antimicrobial Peptide"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"How Neisseria gonorrhoeae Emerged as a Superbug: Are Current Strategies to Combat AMR Effective?"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Mapping the Malaria Parasite Druggable Genome by Using In Vitro Evolution and Chemogenomics"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Suppressor Cell-Targeted Immunotherapy with Denileukin Diftitox, a Recombinant Toxin, Improves TB Treatment"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Heterogeneity in Mammalian Drug Resistance"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Mechanisms of Antibiotic Resistance in Pseudomonas aeruginosa Swarming Motility"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Network Biology and Infectious Disease"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Intra-Tumor Heterogeneity in Resistance to Targeted Cancer Therapies"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Anti-Evolution Therapies for Cancer"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Drug Resistant Cancers Harbor Collateral Vulnerabilities that Can Be Leveraged to Select Against Resistance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Novel Phage Platforms for Developing Targeted Antibiotics"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Network Stress Tests Reveal Novel Drug Potentiators in Mycobacterium tuberculosis "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Host-Response Based Testing in the Diagnosis of Airway Infections"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"New Technologies for Rapid Infectious Disease Diagnosis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Elucidating the Role of ABCB1 Transcript Fusions in Chemoresistant Ovarian Cancer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Rapid Exploration of Drug Resistance-Conferring Mutations by Targeted Mutagenesis in Pathogenic Bacteria"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"EGFR-Targeted Chemical Proteomics for Elucidating Drug Resistance Mechanisms in Cancer"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure