Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Protecting New Drugs and Pesticides Against Resistance
Discussion Leader: Alexis Kaushansky (University of Washington, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Seva Rostovtsev (FMC Corporation, United States)
"Challenges and Opportunities of Understanding Resistance Mechanisms in Agriculture"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Alina Baum (Regeneron Pharmaceuticals, United States)
"Development of REGN-COV, an Anti-Spike Antibody Cocktail for Treatment and Prevention of COVID-19"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Emergence of Resistance
Discussion Leader: Pradipsinh Rathod (University of Washington, United States)
9:00 am - 9:30 am
Houra Merrikh (Vanderbilt University, United States)
"DNA Repair and the Evolution of Resistance"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Susan Rosenberg (Baylor College of Medicine, United States)
"Stress-Induced Mutagenesis to Drug Resistance and Drugs to Stop It"
10:15 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Arya Kaul (Harvard Medical School, United States)
"Genomics of Resistance Before the Age of Antibiotics"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Andrea Wegrzynowicz (Dept. of Biochemistry, University of Wisconsin-Madison, United States)
"Functional Phenotyping of Small Multidrug Resistance Proteins from Pathogens Reveals Novel Susceptibility Behavior"
11:40 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Sophie Helaine (Harvard Medical School, United States)
"Salmonella Persisters During Infection"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Priscilla Yang (Stanford University School of Medicine, United States) and Sophie Helaine (Harvard Medical School, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Eco-Evolutionary Strategies to Address Resistance
Discussion Leaders: Amir Mitchell (University of Massachusetts Medical School, United States)
7:30 pm - 8:00 pm
Eugene Shakhnovich (Harvard University, United States)
"Biophysics and Evolution of Antibiotic Resistance "
8:00 pm - 8:15 pm
Discussion
8:30 pm - 8:40 pm
Anna Clara Milesi Galdino (Cedars-Sinai Medical Center, United States)
"Pseudomonas aeruginosa Populations in Synthetic Cystic Fibrosis Media Evolve Cooperative Behavior in Response to Cefiderocol Pressure"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Zhenyu Li (Brandeis University, United States)
"Hemagglutinin Stability Determines Influenza A Virus Susceptibility to a Broad-Spectrum Fusion Inhibitor Arbidol"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:30 pm
Andriy Marusyk (Moffitt Cancer Center, United States)
"Microenvironmental Stromal Sheltering as a “Dark Matter” in Evolutionary Dynamics of Acquired Therapy Resistance"
9:30 pm - 9:45 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Combating Resistance with Novel Targets
Discussion Leader: Mithila Jugulam (Kansas State University, United States)
9:00 am - 9:30 am
John Aitchison (Seattle Children's Research Institute, University of Washington, United States)
"Exploiting Viral Induced Vulnerabilities to Combat Infectious Diseases"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Emily Derbyshire (Duke University, United States)
"Revealing Parasite Vulnerabilities with Chemical and Genomic Tools "
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Zemer Gitai (Princeton University, United States)
"Bugs to Drugs: Biophysical Approaches to Discovering and Understanding Resistance-Resistant Antibiotics"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Daniel Pierce (Bristol Myers Squibb, United States)
"Overcoming Cereblon Resistance with the Aiolos/Ikaros Degrader CC-92480 for Multiple Myeloma"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Durable Drug Design
Discussion Leader: Timothy Wencewicz (Washington University in St. Louis, United States)
7:30 pm - 8:00 pm
David Epstein (Black Diamond Therapeutics, United States)
"Mechanistic Implications of Oncogene Activation Via Non-Canonical Mutations"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Adam Palmer (UNC Chapel Hill, United States)
"Combination Therapies Cure Some Types of Cancer"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
John Overington (Exscientia, United Kingdom)
"Borges Deep variant Library, a Comprehensive A Priori Library of All Possible Resistance Mutants"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Priscilla Yang (Stanford University School of Medicine, United States)
"Protein Degradation as a Pharmacological Approach to Suppress Resistance"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Systems and Modeling Strategies to Address Resistance
Discussion Leader: Adam Palmer (UNC Chapel Hill, United States)
9:00 am - 9:30 am
Funda Meric-Bernstam (The University of Texas MD Anderson Cancer Center, United States)
"Modeling Acquired Resistance and Rationale Combinations"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
James Welsh (University of Texas MD Anderson Cancer Center, United States)
"Therapeutic Strategies to Address Checkpoint Immune Resistance"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Eachan Johnson (The Francis Crick Institute, United Kingdom)
"Towards Antimicrobial, Anti-Resistance Chemotherapeutic Strategies Using Large-Scale Chemical-Genetics"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Natasha Bourgeois (University of Washington, Seattle Children's Research Institute, United States)
"Targeting Receptor Tyrosine Kinases for Host-Directed Therapeutics Against Dengue Infection"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Chunxiao (Emma) Cui (Xsphera Biosciences Inc., United States)
"Classifying Degree of Cetuximab Response in Colorectal Cancer Using an Ex-Vivo Platform"
11:40 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Nitin Baliga (Institute for Systems Biology, United States)
"Is It Possible to Anticipate, Block, and Reverse Drug Resistance?"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Threats and Responses
Discussion Leaders: Tijana Ivanovic (Brandeis University, United States)
7:30 pm - 8:00 pm
Pradipsinh Rathod (University of Washington, United States)
"Battling Malaria Evolution: Scaling Studies from Labs, to Clinics, to Continents"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Timothy Wencewicz (Washington University in St. Louis, United States)
"Mechanisms and Inhibitors of Tetracycline"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Sarat Chandarlapaty (Memorial Sloan Kettering Cancer Center, United States)
"Resistance to Endocrine Therapy Cancer: Insights from Bedside to Bench Studies"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome and Resistance
Discussion Leader: Shuyi Ma (Seattle Children's Research Institute, United States)
9:00 am - 9:30 am
Yoshitomo Kikuchi (National Institute of Advanced Industrial Science and Technology, Japan)
"Transmissible Pesticide Resistance: Invisible Friends of Insects"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Neha Garg (Georgia Institute of Technology, United States)
"Microbial Response to Antibiotics and Change in Community Structure "
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Wendy Mok (UConn Health, United States)
"Leveraging Bacterial Vulnerabilities to Bolster the Efficacy of Topoisomerase Inhibitors"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Amir Mitchell (University of Massachusetts Medical School, United States)
"Bacterial Evolved Resistance Against Chemotherapies and Its Implication for the Treated Host"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Chi Li (University of Louisville, United States)
"Overcoming Resistance to Apoptosis in Lung Adenocarcinoma Cells by a Bacterial Quorum Sensing Molecule"
11:40 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Peter Belenky (Brown University, United States)
"Microbial Metabolism is a Determinant of Antibiotic-Induced Disruption of the Gut Microbiome"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Emerging Strategies to Combat Resistance
Discussion Leader: Aaron Goldman (Harvard Medical School, United States)
7:30 pm - 8:10 pm
Paul Turner (Yale University, United States)
"Developing Viruses as ‘Evolution-Proof’ Therapies Against Drug-Resistant Bacteria and Cancers"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
Erin Duffy (CARB-X, United States)
"CARB-X Antibacterial Pipeline – Current Status and Future Opportunities"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure