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Drug Resistance

Gordon Research Conference

Strategies to Disrupt Resistance in Infectious Diseases, Cancer and Agriculture

June 26 - July 1, 2022

Chairs

and

Vice Chairs

and

Bryant University

1150 Douglas Pike

Smithfield, Rhode Island, United States

Venue and Travel Information

Conference Description

The prosperity of the modern world is threatened by the emergence of drug resistant pathogens, pesticide-resistant insects and herbicide-resistant weeds. Novel investigational cancer drugs increase life expectancy, but fail when resistance develops. The same principles of evolution drive the development of resistance in all of these contexts, yet each field attacks the problem of resistance alone. The Drug Resistance Gordon Research Conference (DRGRC) provides a unique forum where scientists and physicians working in infectious diseases, cancer and agriculture come together to discuss common issues and share approaches with the conviction that general strategies to minimize resistance can be developed by working together.

As in previous years, the conference strives to recruit a broad array of disciplinary expertise, varying seniority, and wide geographic and cultural perspectives. The organizers are recruiting internationally recognized speakers from infectious disease, cancer and agriculture, including representatives from academics, government organizations, and industry. The organizers also welcome – and will seek out – timely and novel poster presentations and at least twelve outstanding poster presentations will be selected for short oral talks.

Related Meeting

This GRC will be held in conjunction with the "Drug Resistance" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Protecting New Drugs and Pesticides Against Resistance Discussion Leader:
7:40 pm - 7:50 pm	Opening Remarks
7:50 pm - 8:30 pm	"Challenges and Opportunities of Understanding Resistance Mechanisms in Agriculture"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:20 pm	"Development of REGN-COV, an Anti-Spike Antibody Cocktail for Treatment and Prevention of COVID-19"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Emergence of Resistance Discussion Leader:
9:00 am - 9:30 am	"DNA Repair and the Evolution of Resistance"
9:30 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Stress-Induced Mutagenesis to Drug Resistance and Drugs to Stop It"
10:15 am - 10:30 am	Discussion
10:30 am - 11:05 am	Coffee Break
11:05 am - 11:20 am	"Genomics of Resistance Before the Age of Antibiotics"
11:20 am - 11:25 am	Discussion
11:25 am - 11:40 am	"Functional Phenotyping of Small Multidrug Resistance Proteins from Pathogens Reveals Novel Susceptibility Behavior"
11:40 am - 11:45 am	Discussion
11:45 am - 12:15 pm	"Salmonella Persisters During Infection"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Eco-Evolutionary Strategies to Address Resistance Discussion Leaders:
7:30 pm - 8:00 pm	"Biophysics and Evolution of Antibiotic Resistance "
8:00 pm - 8:15 pm	Discussion
8:30 pm - 8:40 pm	"Pseudomonas aeruginosa Populations in Synthetic Cystic Fibrosis Media Evolve Cooperative Behavior in Response to Cefiderocol Pressure"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Hemagglutinin Stability Determines Influenza A Virus Susceptibility to a Broad-Spectrum Fusion Inhibitor Arbidol"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:30 pm	"Microenvironmental Stromal Sheltering as a “Dark Matter” in Evolutionary Dynamics of Acquired Therapy Resistance"
9:30 pm - 9:45 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Combating Resistance with Novel Targets Discussion Leader:
9:00 am - 9:30 am	"Exploiting Viral Induced Vulnerabilities to Combat Infectious Diseases"
9:30 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Revealing Parasite Vulnerabilities with Chemical and Genomic Tools "
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:30 am	"Bugs to Drugs: Biophysical Approaches to Discovering and Understanding Resistance-Resistant Antibiotics"
11:30 am - 11:45 am	Discussion
11:45 am - 12:15 pm	"Overcoming Cereblon Resistance with the Aiolos/Ikaros Degrader CC-92480 for Multiple Myeloma"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Durable Drug Design Discussion Leader:
7:30 pm - 8:00 pm	"Mechanistic Implications of Oncogene Activation Via Non-Canonical Mutations"
8:00 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Combination Therapies Cure Some Types of Cancer"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Borges Deep variant Library, a Comprehensive A Priori Library of All Possible Resistance Mutants"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:15 pm	"Protein Degradation as a Pharmacological Approach to Suppress Resistance"
9:15 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Systems and Modeling Strategies to Address Resistance Discussion Leader:
9:00 am - 9:30 am	"Modeling Acquired Resistance and Rationale Combinations"
9:30 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Therapeutic Strategies to Address Checkpoint Immune Resistance"
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Towards Antimicrobial, Anti-Resistance Chemotherapeutic Strategies Using Large-Scale Chemical-Genetics"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Targeting Receptor Tyrosine Kinases for Host-Directed Therapeutics Against Dengue Infection"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Classifying Degree of Cetuximab Response in Colorectal Cancer Using an Ex-Vivo Platform"
11:40 am - 11:45 am	Discussion
11:45 am - 12:15 pm	"Is It Possible to Anticipate, Block, and Reverse Drug Resistance?"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm	Threats and Responses Discussion Leaders:
7:30 pm - 8:00 pm	"Battling Malaria Evolution: Scaling Studies from Labs, to Clinics, to Continents"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Mechanisms and Inhibitors of Tetracycline"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Resistance to Endocrine Therapy Cancer: Insights from Bedside to Bench Studies"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Microbiome and Resistance Discussion Leader:
9:00 am - 9:30 am	"Transmissible Pesticide Resistance: Invisible Friends of Insects"
9:30 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Microbial Response to Antibiotics and Change in Community Structure "
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Leveraging Bacterial Vulnerabilities to Bolster the Efficacy of Topoisomerase Inhibitors"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Bacterial Evolved Resistance Against Chemotherapies and Its Implication for the Treated Host"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Overcoming Resistance to Apoptosis in Lung Adenocarcinoma Cells by a Bacterial Quorum Sensing Molecule"
11:40 am - 11:45 am	Discussion
11:45 am - 12:15 pm	"Microbial Metabolism is a Determinant of Antibiotic-Induced Disruption of the Gut Microbiome"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Emerging Strategies to Combat Resistance Discussion Leader:
7:30 pm - 8:10 pm	"Developing Viruses as ‘Evolution-Proof’ Therapies Against Drug-Resistant Bacteria and Cancers"
8:10 pm - 8:25 pm	Discussion
8:25 pm - 9:05 pm	"CARB-X Antibacterial Pipeline – Current Status and Future Opportunities"
9:05 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R13AI169932. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Drug Resistance (GRS)

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