Session 1
(Sunday evening) |
Elastogenesis, morphogenic and growth |
| Discussion leader: Charlie Little |
- Mark Majeski - Differentiation of coronary vascular smooth muscle
- Katalin Csiszar - Developmental expression of lysyl oxidase-like gene
- Paul Skoglund - Role of fibrillin 2 in Xenopus gastrulation
- Emilio Arteaga - Role of fibrillin 2 in vertebrate limb morphogenesis
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Session 2
(Monday morning) |
Molecular interactions |
Discussion leader: Cay Kielty |
- Lynn Sakai - Interactions with Fibrillins
- Mark Gibson - Cellular interactions of MAGP-2
- Robert Mecham - Elastin self-assembly: does it or doesn't it?
- Alfonso Colombatti - Emilin, a component of the elastic fiber and a new member of the ClqTNF superfamily of proteins
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Session 3
(Monday evening) |
Growth factors and elastic tissues |
Discussion leader: Dan Rifkin |
- Juha Saharinen – Molecular analysis of TGF-beta and LTBPs 1-4 interactions
- Mike Shipley – Consequence of LTBP2 loss
- Dan Rifkin - Biological functions of LTBPs
- Lynda Bonewald - LTBP role in new bone formation
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Session 4
(Tuesday morning) |
Proteases and proteolytic processes |
Discussion leader: Steve Shapiro |
- Stephan Baynoff – Immunological aspects of age related elastin turnover
- Edward Campbell – Focus and control of extracellular enzymes through cell-surface binding.
- Steve Shapiro - Elastic fibers and chronic inflammation
- Rob Thompson - Role of elastases in aortic aneurysm
- Tim Baxter - MMP-2 and MT1-MMP in aortic aneurysms
- Enid Neptune - Elastolysis and cell de-differentiation in the diseased aorta
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Session 5
(Tuesday evening) |
Structure and new microfibrillar components |
Discussion leader: Rupert Timpl |
- Penny Hanford – Structural and biological consequences of N to S mutations in fibrillin-1 cbEGF domains
- Kristy Downing - Investigating the role of calcium in human fibrillin-1
- Rupert Timpl - Endostatin association with microfibrils
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Session 6
(Wednesday morning) |
Assembly |
Discussion leader: Robert Mecham |
- Jean Schwarzbauer – Cooperation between fibronectin and integrin during matrix fibril assembly
- Cay Kielty – Assembly of recombinant fibrillin molecules
- Barbara Crippes Trask - Binding domain on fibrillin for MAGP
- Tony Weiss - Tropoelastin and microfibrillar protein binding by tropoelastin domains
- Alex Hinek - new insights into elastic fiber assembly; lessons from diseases involving proteoglycan degradation
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Session 7
(Wednesday evening) |
Gene expression |
Discussion leader: Bill Parks |
- Jeff Ross – Mechanisms of mRNA stability
- Bill Parks - Tropoelastin mRNA binding protein
- Fred Keeley - Secondary structure of tropoelastin mRNA
- Joel Rosenbloom – TGF-beta regulation of elastin production
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Session 8
(Thursday morning) |
Human and mouse models of elastic fiber diseases |
Discussion leader: Lynn Sakai |
- Joni Uitto - Heritable disorders of the elastic fiber system
- Gunther Kostka - Lessons from fibulin 1 mutant mice
- Diana Milewicz - Fibrillin-1 and scleroderma
- Barbara Gayraud - Tsk vs. Marfan mutations
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Session 9
(Thurday evening) |
Emerging topics and new challenges: an extemporary view of GC '99 |
Discussion leader: Jeff Davidson |
