| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MOLECULAR STRUCTURE OF ELASTIC FIBER PROTEINS |
| Discussion Leaders: Robert Mecham (Washington University
School of Medicine)
Tony Tamburro, (Universita Deglistudi Della Basilicata) |
| 7:30 pm - 7:45 pm | Robert Mecham (Washington University School of Medicine)
“Introduction to structure/function of elastic fiber protein” |
| 7:45 pm - 8:15 pm | Tony Tamburro (Universita Deglistudi Della Basilicata)
“The molecular mechanism of elasticity of elastomeric protein” |
| 8:15 pm - 8:45 pm | Paul Guerette (University of British Columbia)
"Molecular structure and assembly of silk proteins" |
| 8:45 pm - 9:15 pm | Alain Alix (University of Reims)
"Common structures in elastin and tumstatin" |
| 9:15 pm - 9:30 pm | Elizabeth Kress (Flight Attendants Medical Research Institute - FAMRI)
Steven Shapiro (Brigham and Women’s Hospital)
“FAMRI and Alpha-1 Foundation: Mission and research opportunities” |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 10:00 pm | ELASTIC FIBER ASSEMBLY AT THE MOLECULAR LEVEL – PART I |
| Discussion Leaders: Fred Keeley (Hospital for Sick Children)
Elaine Davis (McGill University) |
| 9:00 am - 9:30 am | Fred Keeley (Hospital for Sick Children)
“Introduction – Mechanisms of molecular assembly: Assisted and unassisted” |
| 9:30 am - 10:00 am | Anthony Weiss (University of Sydney)
Steven Wise, Suzanne Mithieux (University of Sydney)
"Cross-linking regions and exposed lysines in tropoelastin" |
| 10:00 am - 10:30 am | Robert Mecham (Washington University School of Medicine)
“Micro and macro assembly of elastin: How the cell makes a fiber” |
| 10:30 am | Coffee Break |
| 11:00 am - 12:30 pm | ELASTIC FIBER ASSEMBLY: TISSUE ORGANIZATION - PART II |
| 11:00 am - 11:30 am | Elaine Davis (McGill University)
“Introduction - Different requirements in different tissues” |
| 11:30 am - 12:00 pm | Barry Starcher (University of Texas Health Center at Tyler)
“The organization of elastic fibers in the skin of different animals: Relationship to function” |
| 12:00 pm - 12:30 pm | Timothy M Ritty (Washington University School of Medicine)
“Elastic fiber proteins and a unique fibrillin-2 containing structure in tendon” |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GENETICS AND FUNCTIONAL GENOMICS OF ELASTIC TISSUES |
| Discussion Leader: Francesco Ramirez (Hospital for Special
Surgery) |
| 7:30 pm - 8:00 pm | Tom Mariani (Brigham and Women’s Hospital)
“Expression profiling in lung development” |
| 8:00 pm - 8:30 pm | Benjamin Raby (Brigham and Women’s Hospital)
“Elastin mutations in COPD” |
| 8:30 pm - 9:00 pm | Sean McClean (Washington University)
“Vascular development in wild-type and elastin mutant mice “ |
| 9:00 pm - 9:30 pm | McGarry Houghton (Brigham and Women’s Hospital)
“Elastin fragments and emphysema“ |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MICROFIBRIL STRUCTURE AND ASSEMBLY |
| Discussion Leaders: Mark Gibson (University of Adelaide)
Cay Kielty (University of Manchester) |
| 9:00 am - 9:30 am | Penny Handford (University of Oxford)
Sacha Jensen (University of Oxford)
“Crystal structure of the integrin binding fragment of fibrillin-1-implications for homologous regions of fibrillin-1” |
| 9:30 am - 10:00 am | Clair Baldock (University of Manchester)
“Cryo-EM of isolated microfibrils, and small-angle X-ray scattering of fibrillin-1 molecules” |
| 10:00 am | Coffee Break |
| 10:30 am - 10:45 am | Sarah Petke (Washington University School of Medicine)
“QFDE domain mapping of extracted and unextracted microfibrils” |
| 10:45 am - 11:00 am | Ian Hornstra (Washington University)
“Tissue laxity and lung inflammation in LOX L1 deficient mice” |
| 11:00 am - 11:15 am | Eric Hanssen (Adelaide University)
“Mapping of MAGP-2 to tissue microfibrils” |
| 11:15 am - 11:45 am | Dieter Reinhardt (University of Lubeck)
“HSPGs/their receptors and role in microfibril assembly” |
| 11:45 am - 12:15 pm | Cay Kielty (University of Manchester)
“Intra- and inter-molecular interactions of fibrillin-1, proteomic studies of microfibrils” |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MICROFIBRIL-ASSOCIATED PROTEINS |
| Discussion Leaders: Lynne Sakai (Shriners Hospital for Children)
Jorma Keski-Oja (University of Helsinki) |
| 7:30 pm - 8:00 pm | Jorma Keski-Oja (University of Helsinki)
“LTBP 4 and LTBPs in general” |
| 8:00 pm - 8:30 pm | Dan Rifkin (NYU School of Medicine)
“Approaches to the characterization of LTBP in TGFbeta function” |
| 8:30 pm - 9:00 pm | Harald von Melchner (University of Frankfurt Medical School)
"Extracellular matrix production and TGF-beta signaling in the absence of LTBP-4: Lessons from the knock out mice" |
| 9:00 pm - 9:30 pm | Lynne Sakai (Shriners Hospital for Children)
“Interactions between fibrillins and TGFbeta-related growth factors” |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ROLE OF ELASTIC FIBER PROTEINS IN DEVELOPMENT |
| Discussion Leaders: Charles Little (Kansas U. Medical Center)
Sarah Dallas (University of Missouri, Kansas City) |
| 9:00 am - 9:30 am | Bette Dzamba (University of Virginia)
“Fibrillin’s role in early vertebrate morphogenesis using Xenopus” |
| 9:30 am - 10:00 am | Brenda Rongish (University of Kansas Medical Center)
“Time lapse computational analysis of fibrillin-2 during axis formation in the bird” |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Charles Whittaker (Whitehead Institute/MIT Center for Genome Research)
“The evolution of matrix and cell adhesion molecules in mining the genome of organisms” |
| 11:00 am - 12:30 pm | POSTER SESSION AUTHORS TO GIVE TALK and DISCUSSION |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:15 pm - 8:00 pm | Business Meeting |
| 8:00 pm - 9:30 pm | REGULATION OF ELASTIC FIBER PROTEIN EXPRESSION/ASSEMBLY |
| Discussion Leaders: Joel C. Rosenbloom (University of
Pennsylvania School of Dental Medicine)
Judith A. Foster (Boston University School of Medicine) |
| 8:00 pm - 8:30 pm | Judith A. Foster (Boston University School of Medicine)
“Transcriptional regulation of elastin” |
| 8:30 pm - 9:00 pm | Thomas Wight (The Hope Heart Institute)
“Elastin-proteoglycan interactions” |
| 9:00 pm - 9:30 pm | Group Discussion: Is full elastic fiber assembly necessary for tissue repair? |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DISEASE OF ELASTIC FIBER PROTEINS |
| Discussion Leaders: Marlene Rabinovitch (Stanford University)
Jeff Davidson (Vanderbilt University School of Medicine) |
| 9:00 am - 9:30 am | Marlene Rabinovitch (Stanford University)
“Pulmonary hypertension” |
| 9:30 am - 10:00 am | Zsolt Urban (PBRC, University of Hawaii)
“Supravalvular aortic stenosis (SVAS) syndrome” |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Richard Pierce (Washington University)
“Pulmonary fibrosis” |
| 11:00 am - 11:30 am | Phil Pemberton (Arriva, CA)
“Novel approaches to preserving elastin architecture in pulmonary disease” |
| 11:30 am - 12:00 pm | Joost Schalkwijk (University Medical Center Nijmegen)
“Tenascin-x KO mice have Ehlern-Danlos syndrome” |
| 12:00 pm - 12:30 pm | Enid Neptune (Johns Hopkins School of Medicine)
“Fibrillin and TGFb” |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BIOMATERIALS AND TISSUE ENGINEERING |
| Discussion Leader: Anthony S Weiss (University of Sydney) |
| 7:30 pm - 7:50 pm | Anthony S Weiss (University of Sydney)
“Synthetic elastin” |
| 7:50 pm - 8:10 pm | Dean Li (University of Utah)
“Elastin and models of restenosis” |
| 8:10 pm - 8:30 pm | Ivan Vesely (The Cleveland Clinic Foundation)
“Tissue engineering of elastin structures in the aortic valve” |
| 8:30 pm - 8:50 pm | Fred Keeley (Hospital for Sick Children)
“Self-assembling biomaterials from model elastin polypeptides” |
| 8:50 pm - 9:10 pm | Tony Tamburro (Universita Deglistudi Della Basilicata)
“Synthesis and characterization of potential elastin-like biomaterials” |
| 9:10 pm - 9:30 pm | Cay Kielty (University of Manchester)
“Fibrillin fragments as cell adhesion ligands in tissue engineering” |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
