SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | STRUCTURES OF ELASTIC FIBER MOLECULES |
| Discussion Leaders: Penny Handford (University of Oxford, UK) & Fred Keeley (Hospital for Sick Children, Toronto, Canada) |
7:40 pm - 8:05 pm | John Parkinson (Hospital for Sick Children, Toronto, Canada)
"Bioinformatics approaches to elastin structure" |
8:05 pm - 8:30 pm | Kristin Kumashiro (Dept. of Chemistry, University of Hawaii)
"Solid-state NMR as a tool to elucidate elastin structure" |
8:30 pm - 8:45 pm | Tony Tamburro (University of Potenza, Italy)
"Amyloid formation by exon 30 of human elastin" |
8:45 pm - 9:10 pm | Clair Baldock (University of Manchester, UK)
"Solution structure of fibrillin-1 by SAXS" |
9:10 pm - 9:30 pm | Christina Redfield (University of Oxford, UK)
"Fibrillin molecular structure" |
9:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MICROFIBRIL AND ELASTIC FIBER ASSEMBLY |
| Discussion Leaders: Brenda Rongish (University Kansas Med. Center, USA) & Dieter Reinhardt (McGill University, Canada) |
9:00 am - 9:25 am | Cay Kielty (University of Manchester, UK)
"Role of receptors in microfibril assembly" |
9:25 am - 9:50 am | Tom Wight (Benaroya Research Institute, Seattle, USA)
"Proteoglycans, cells and elastogenesis" |
9:50 am - 10:15 am | Dieter Reinhardt (McGill University, Canada)
"Fibrillin organization in health and disease" |
10:15 am - 10:45 am | Coffee Break / Photo |
10:45 am - 11:10 am | Andras Czirok (Univ. Kansas Med. Center, Eotvos Univ, Hungary)
"ECM dynamics in the developing embryo" |
11:10 am - 11:35 am | Sarah Dallas (University of Missouri Kansas City, MO, USA)
"Dynamics of assembly of microfibrillar proteins in osteoblasts" |
11:35 am - 12:00 pm | Jessica Wagenseil (Washington University, St Louis, USA)
"Dynamic imaging of elastic fiber assembly" |
12:00 pm - 12:15 pm | Risa Nonaka (Hoshi University, School of Pharmacy)
"Interaction of elastin, fibrillin-1 and fibulin-5 in elastic fiber assembly" |
12:15 pm - 12:30 pm | Jiwon Choi (McGill University, Montreal, Canada)
"Fibulin-5 null mice reveal that fibulin-5 is essential for cutaneous elastic fiber assembly and mechanical property of skin" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | POSTER SESSION I:
'ELASTIC FIBER STRUCTURE, ASSEMBLY AND FUNCTION', 'LYSYL OXIDASES' |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ELASTIC TISSUE DEVELOPMENT |
| Discussion Leaders: Robert Mecham (Wash. University, St Louis, USA) & Charles Little (University of Kansas Medical Center, USA) |
7:30 pm - 7:55 pm | Evan Zamir (University of Kansas Medical Center, USA)
"Dynamic computational analysis of cells and ECM during vessel formation de novo" |
7:55 pm - 8:20 pm | Eiichi Hirano (Washington University, St Louis, USA)
"Influences of ECM on vessel wall formation" |
8:20 pm - 8:45 pm | Andrew White (Washington University, St Louis, USA)
"Growth factor signals in lung and pulmonary vascular development" |
8:45 pm - 9:30 pm | 3 talks to be selected from poster presenters |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LYSYL OXIDASES |
| Discussion Leaders: Katalin Csiszar (University of Hawaii, USA) & Robert Rucker (University of California, Davis, USA) |
9:00 am - 9:10 am | Robert Rucker (Univ. California, Davis)
"Processing and activation of lysyl oxidase" |
9:10 am - 9:35 am | Herb Kagan (Boston University School of Medicine, USA)
"Electrostatic specificity factors and intracellular transport of lysyl oxidase" |
9:35 am - 10:00 am | Katalin Csiszar (University of Hawaii, USA)
"LOX in epithelial-mesenchymal transition" |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Philip Trackman (Boston University School of Medicine, USA)
"Fate and functions of the lysyl oxidase pro-peptide" |
10:55 am - 11:20 am | Pascal Sommer (University of Lyon, France)
"Regulation of lysyl oxidase in human skin and skin equivalent model" |
11:20 am - 11:45 am | Tiansen Li (Harvard Medical School, USA)
"Role of lysyl oxidase like 1 (LOXL1) in elastic fiber maintenance, and novel disease implications" |
11:45 am - 12:10 pm | Ian Hornstra (Washington University, St Louis, USA)
"Decreased aortic compliance in the LOXL null mice" |
12:10 pm - 12:30 pm | 1 talk selected from poster presenters |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | POSTER SESSION I:
'ELASTIC FIBER STRUCTURE, ASSEMBLY AND FUNCTION', 'LYSYL OXIDASES'
[Remove posters after this session / put up posters for Session II] |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ELASTIC FIBER MOLECULES - KNOCK-OUT MODELS |
| Discussion Leaders: Elaine Davis (McGill University, Canada) & Michael Shipley (Washington University, St Louis, USA) |
7:30 pm - 7:55 pm | Giorgio Bressan (University of Padova, Italy)
"Emilin-1 knockout mouse" |
7:55 pm - 8:20 pm | Jouni Uitto (Thomas Jefferson University, Philadelphia, USA)
"Targeted ablation of the ABCC6 gene results in ectopic calcification of connective tissues: a model model for PXE" |
8:20 pm - 8:45 pm | Luca Carta (Hospital for Special Surgery, Weill College of Medicine of Cornell University, NY, USA)
"Fibrillin-1 and the double fibrillin-1/-2 knockout mice" |
8:45 pm - 9:00 pm | Gilles Faury (Universite Joseph Fourier, Grenoble, France)
"Arterial structure and function of aging mice hemizygous for elastin" |
9:00 pm - 9:15 pm | Tomoyuki Nakamura (Kyoto University, Japan)
"Molecular mechanisms of elastic fiber organization by DANCE/fibulin-5" |
9:15 pm - 9:30 pm | Michael Shipley (Wash. Uni. School of Medicine, St Louis)
"Microfibril-associated protein-4 (MFAP-4) interactions with collagen and is important for lung development" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | HERITABLE ELASTIC FIBER DISORDERS |
| Discussion Leaders: Zsolt Urban (Washington University, St Louis USA) & Dianna Milewicz (University of Texas, USA) |
9:00 am - 9:25 am | Dianna Milewicz (University of Texas, USA)
"TGFBR2 mutations in vascular disease" |
9:25 am - 9:50 am | Geert Mortier (Ghent University Hospital, Ghent, Belgium)
"Heterozygous mutations in LEMD3 cause Buschke-Ollendorff syndrome" |
9:50 am - 10:15 am | Hiromi Yanigasawa (UT Southwestern, USA)
"Molecular analysis of fibulin-5 in elastic fiber assembly" |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Zsolt Urban (Washington University, St Louis, USA)
"Candidate gene studies in cutis laxa" |
11:10 am - 11:35 am | András Váradi (Institute of Enzymology, HAS, Budapest, Hungary)
"Functional analysis of PXE mutations" |
11:35 am - 12:00 pm | Ivonne Ronchetti (University of Modena, Italy)
"Functional genomics in PXE model" |
12:00 pm - 12:30 pm | 2 talks selected from poster presenters |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | POSTER SESSION II:
'ELASTIC FIBER MICE MODELS, GROWTH FACTORS', 'ELASTIC FIBER DISORDERS, ELASTIN ENGINEERING' |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ELASTIC FIBERS AND GROWTH FACTORS |
| Discussion Leaders: Lynn Sakai (Shriners Hospital, Portland, OR, USA) & Dan Rifkin (New York University, USA) |
7:30 pm - 7:55 pm | Vesna Todorovic (New York University, USA)
"LTBP-1 knock-out mice" |
7:55 pm - 8:20 pm | Gerhardt Sengle (Shriners Hospital, Portland, OR, USA)
"TGF-ß family members binding to fibrillins" |
8:20 pm - 8:45 pm | Katri Koli (University of Helsinki, Finland)
"LTBP-4 knock-out and in vitro functions" |
8:45 pm - 9:10 pm | Bart Loeys (Johns Hopkins, Baltimore, USA)
"Dietz-Loeys syndrome" |
9:10 pm - 9:30 pm | 1 talk selected from poster presenters |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DEGENERATIVE ELASTIC FIBER DISORDERS |
| Discussion Leaders: Bill Parks (Seattle, USA) & Steve Shapiro (Harvard University, Boston, USA) |
9:00 am - 9:25 am | Marlene Rabinovitch (Stanford University, USA)
"Vascular disease" |
9:25 am - 9:50 am | Robert Thompson (Washington University, St Louis, USA)
"Matrix breakdown on aneurysm" |
9:50 am - 10:15 am | Steve Shapiro (Harvard University, USA)
"SOS: Emphysema" |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Charles Boyd (University of Hawaii)
"The systems biology of solar elastosis" |
11:10 am - 11:35 am | Richard Pierce (Washington University, St Louis, USA) |
11:35 am - 11:55 am | Richard Bland (Stanford University, USA)
"Prolonged Mechanical Ventilation of Newborn Mice: Impact on Genes that Regulate Formation of Alveoli, Blood Vessels and Elastic Fibers in
the Developing Lung" |
11:55 am - 12:30 pm | 2 talks selected from poster presenters |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | POSTER SESSION II:
'ELASTIC FIBER MICE MODELS, GROWTH FACTORS', 'ELASTIC FIBER DISORDERS, ELASTIN ENGINEERING'
[Remove posters after this session] |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | BUSINESS MEETING |
7:45 pm - 9:30 pm | ELASTIC FIBER ENGINEERING AND BIOMATERIALS |
| Discussion Leader: Tony Weiss (University of Sydney, Australia) |
7:45 pm - 8:10 pm | Fred Keeley (Hospital for Sick Children, Toronto, Canada)
"Sequence, structure and mechanical properties of elastin-based biomaterials" |
8:10 pm - 8:35 pm | Tony Weiss (University of Sydney, Australia)
"Elastin tissue engineering" |
8:35 pm - 9:00 pm | Alessandro Gandaglia (Clemson University, USA; Padua, Italy)
"Porcine purified pulmonary elastin valve cusp for bioprostethic tissue engineering" |
9:00 pm - 9:15 pm | Alex Seifalian (University College London, UK)
"Engineering of small-diameter vascular grafts" |
9:15 pm - 9:30 pm | Richard Black (University of Liverpool, UK)
"Fabrication of vascular graft scaffolds" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |