SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
4:00 pm - 6:00 pm | Free Time / Informal Gathering in the Pub |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome by Elaine C. Davis and Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | MOLECULAR STRUCTURE AND PROPERTIES OF ELASTIN |
7:45 pm - 7:50 pm | Introduction by Discussion Leader: Robert Mecham (Washington University School of Medicine, USA) |
7:50 pm - 8:10 pm | Anthony Weiss (University of Sydney, Australia) "Flexibility in the solution structure of tropoelastin" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Régis Pomès (University of Toronto, Canada) "Proline and glycine control protein self-organization into elastomeric or amyloid fibrils" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Tony Tamburro (Universita Deglistudi Della Basilicata, Italy) "Self aggregation and molecular mechanisms of elasticity of elastomeric proteins: Towards a unified model" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Kristin K. Kumashiro (University of Hawaii, USA) "Novel insights into elastin's structure using solid-state NMR spectroscopy" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Chair’s Reception in the Pub |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | MICROFIBRIL ULTRASTRUCTURE AND ASSEMBLY |
9:00 am - 9:05 am | Introduction by Discussion Leader: Clair Baldock (University of Manchester, UK) |
9:05 am - 9:30 am | Clair Baldock (University of Manchester, UK)
"The organisation of fibrillin microfibrils from TEM and image analysis" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Sacha Jensen (University of Oxford, UK) "Intra and intermolecular interactions mediated by TB domains of human fibrillin-1" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Dieter Reinhardt (McGill University, Canada) "C-terminal oligomerization provides the basis for fibrillin-1 self-interaction - Does the bead finally reveal its secret?" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:15 am | Zenzo Isogai (National Center for Geriatrics and Gerontonlogy, Japan) "Morphological and functional heterogeneity of microfibril" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Robert P. Mecham (Washington University School of Medicine, USA) "Biological function of microfibril-associated glycoprotein-1, MAGP-1" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Stuart Cain (University of Manchester, UK) "Molecular fishing - The search for new matrix interactions" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | Poster Highlights |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I - Authors present at the odd numbered posters |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | EVOLUTION AND FUNCTIONAL ANALYSIS OF ELASTIC FIBER PROTEINS IN NON-MAMMALIAN MODELS |
7:30 pm - 7:35 pm | Introduction by Discussion Leader: Fred Keeley (University of Toronto, Canada) |
7:35 pm - 7:55 pm | Fred Keeley (University of Toronto, Canada) "Phylogenetic insights into the structure/function and evolutionary history of elastins" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Stephen Ekker (University of Minnesota, USA) "Insights into the biology of the vascular matrix and smooth muscle from the zebrafish" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Bruce Vogel (University of Maryland, USA) "Molecular genetics of elastic fiber-like structures in C. elegans" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Ming Miao (Hospital For Sick Children, Toronto, Canada) "Frog elastins: The role of C-terminal - Now you need it, now you don’t" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
9:30 pm | Informal Discussion in Pub |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ELASTIC FIBER ASSEMBLY |
9:00 am - 9:05 am | Introduction by Discussion Leader: Charlie Little (The University of Kansas Medical Center, USA) |
9:05 am - 9:25 am | Charlie Little (The University of Kanas Medical Center, USA) "Do the forces that shape the embryo drive matrix assembly?" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Rocky Tuan (NIAMS, NIH, USA) "Electrospun nanofibrous scaffolds for cell-based matrix assembly in engineered skeletal tissues" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Tomoyuki Nakamura (Kansai Medical University, Japan) "The role of fibulin-5/DANCE on elastic fiber assembly" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:10 am | Hiroshi Wachi (Hoshi University, Japan) "Characteristic of elastic fiber assembly with recombinant tropoelastin isoforms" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Judith Cirulis (University of Toronto, Canada) "Fibrillin-1 and fibulin-5 modulate in vitro maturation of coacervates of elastin-like polypeptides" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Mervyn J. Merrilees (University of Auckland, New Zealand) "Stimulation of an elastogenic phenotype by hyaluronan binding complex (Metastatin)" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Barry Starcher (University of Texas Health Center at Tyler, USA) "Abnormal elastic fiber assembly in the neuraminidase null mouse" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Poster Highlights |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (con't) - Authors present at the even numbered posters |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | REGULATION OF GROWTH FACTORS AND CELL FUNCTION BY ELASTIC FIBER PROTEINS |
7:30 pm - 7:40 pm | Introduction by Discussion Leader: Lynn Sakai (Portland Shriners Research Center, USA) |
7:40 pm - 8:00 pm | Gerhard Sengle (Portland Shriners Research Center, USA) "Regulation of growth factors by microfibrils" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Takeshi Tsuda (Alfred I. duPont Hospital for Children, Delaware, USA) "Fibulin-2 modulates TGF-β signaling in cardiac remodeling" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Dan Rifkin (New York University School of Medicine, USA) "The role of LTBP in the action of TGF-beta" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Giorgio Bressan (University of Padua, Italy) "Role of emilin-1 in different cells of the vascular system" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Informal Discussion in the Pub |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | HERITABLE DISEASES OF THE VASCULAR SYSTEM: BASIC SCIENCE AND THERAPEUTIC ADVANCES |
9:00 am - 9:05 am | Introduction by Discussion Leader: Dianna Milewicz (The University of Texas Medical School at Houston, USA) |
9:05 am - 9:30 am | Hal Dietz (Johns Hopkins University School of Medicine, USA) "Marfan syndrome and related disorders: from molecules to medicines" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Xiucui Ma (Washington University School of Medicine, USA) "Aortic dilatation in mucopolysaccharidosis is due to upregulation of MMP-12 and cathepsin S" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Dianna Milewicz (The University of Texas Medical School at Houston, USA) "Genetic basis of vascular diseases" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Rob Thompson (Washington University School of Medicine, USA) "Elastin degradation and aortic aneurysms" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Luca Carta (University of Medicine and Dentistry of New Jersey, USA) "Characterization of the aortic VSMC phenotypes in fibrillin-1 mutant mouse models" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Hiromi Yanagisawa (University of Texas Southwestern Medical Center, USA) "In vivo analysis of the role of fibulin-5 integrin binding for elastic fiber assembly and vessel development" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Poster Highlights |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II - Authors present at the odd numbered posters |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ELASTIC FIBER FUNCTION IN SKIN DEVELOPMENT, DISEASES AND AGING |
7:30 pm - 7:35 pm | Introduction by Discussion Leader: Zsolt Urban (Washington University School of Medicine, USA) |
7:35 pm - 7:55 pm | Bart Loeys (Ghent University, Belgium) "Domain-specific mutations in fibrillin-1 cause a congenital form of scleroderma: Stiff Skin Syndrome" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Zsolt Urban (Washington University School of Medicine, USA) "Fibulin gene mutations in cutis laxa" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:40 pm | Olivier Vanakker (Ghent University, Belgium) "A novel PXE-like disorder, caused by mutations in the GGCX gene suggests a pathogenetic role for vitamin K-dependent inhibitors of calcification in PXE" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Aleksander Hinek (University of Toronto, Canada) "Stimulation of elastic fiber production in aging and metabolically challenged human skin" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Violetta Iotsova-Stone (Johnson & Johnson, USA) "Induction of elastin synthesis and inhibition of elastase activity by soybean extracts" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Informal Discussion in the Pub |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | ELASTIC FIBER PATHOGENESIS IN DESTRUCTIVE DISEASE OF THE LUNGS |
9:00 am - 9:05 am | Introduction by Discussion Leader: Marlene Rabinovitch (Stanford University, USA) |
9:05 am - 9:30 am | Marlene Rabinovitch (Stanford University, USA) "Infection, immunity and elastase in pulmonary hypertension" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Richard Bland (Stanford University, USA) "Adverse effects of mechanical ventilation (prolonged cyclic stretch) on lung elastin and alveolar septation in newborn mice" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Steve Shapiro (University of Pittsburgh, USA) "Importance of elastin turnover in COPD" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Adrian Shifren (Washington University School of Medicine, USA) "Injury and repair in elastin insufficient lungs" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Ronald Goldstein (Boston University, USA) "Regulation of elastin transcription in lung fibroblasts" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Richard Pierce (Washington University School of Medicine, USA) "Cathepsin S null mice are protected from hyperoxic injury" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Poster Highlights |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (con't) - Authors present at the even numbered posters |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEW ADVANCES IN ELASTOGENIC BIOMATERIALS AND BIOENGINEERING |
7:30 pm - 7:40 pm | Introduction by Discussion Leader: Anthony Weiss (University of Sydney, Australia) |
7:40 pm - 8:05 pm | Naren Vyavahare (Clemson University, USA) "Elastin biomaterials: The path from pathology to regeneration" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Laura Niklason (Duke University, USA) "Role of elastin in engineered tissues" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Joyce Wong (Boston University, USA) "Building structure into tissue-engineered blood vessels" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Marsha W. Rolle (Worcester Polytechnic Institute, USA) "Cell culture and genetic engineering approaches to promote elastin synthesis in vascular grafts" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Informal Discussion in the Pub |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |