SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
4:00 pm - 6:00 pm | Free Time / Informal Gathering in the Pub |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff and Conference Chair, Tony Weiss |
7:45 pm - 9:30 pm | Molecules of the Elastic Fiber |
7:45 pm - 7:50 pm | Introduction by Discussion Leaders: Elaine Davis and Penny Handford (McGill University and Oxford University) |
7:50 pm - 8:10 pm | Clair Baldock (University of Manchester, UK) "The elastic fiber. Regulation and substrate specificity of tolloid proteinases" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Stuart Cain (University of Manchester, UK) "Elastic fiber proteomics" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Sacha Jensen (University of Oxford, UK) "Fibrillin" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Antonietta Pepe and Brigida Bochicchio (Università della Basilicata, Italy) "The molecular and supramolecular puzzle of elastin. Tribute to Tony Tamburro" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Chair’s Reception in the Pub |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Microfibril and Elastin Ultrastructure, Function and Assembly |
9:00 am - 9:05 am | Introduction by Discussion Leaders: Cay Kielty and Dieter Reinhardt (University of Manchester and McGill University) |
9:05 am - 9:30 am | Francesco Ramirez (Mount Sinai School of Medicine) "Fibrillins role in the regulation of local TGFβ and BMP signals" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Dieter Reinhardt (McGill University) "Fibrillins - Assembly Mechanisms and Differential Expression" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:25 am - 10:50 am | Tim Wess (Cardiff University) "Pleating of fibrillin in microfibrils" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:15 am | Cay Kielty (University of Manchester) "Molecular interactions of fibrillin-1 in elastic fibre assembly" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Tomoyuki Nakamura (Kyoto University) "Fibulin-5" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Mark Gibson (University of Adelaide) "LTBP-2 has multiple heparin/heparan sulfate binding sites" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Tracy Adair-Kirk (Washington University) "Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Dirk Hubmacher (McGill University) "Fibrillin, fibronectin and tropoelastin in homocystinuria: Are inter-molecular disulfide-bonds the common targets for homocysteine in extracellular matrix proteins?" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Molecular Determinants of Elastogenesis and Elastin Destruction |
7:30 pm - 7:35 pm | Introduction by Discussion Leader: Francesco Ramirez (Mount Sinai School of Medicine) |
7:35 pm - 7:55 pm | Pascal Sommer (CNRS/Universite Lyon) "Elastogenesis control through epigenetic mechanisms" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Alek Hinek (University of Toronto) "Pharmacologic interventions in elastogenesis: implications for genetic diseases affecting elastic fibers" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Gilles Faury (Joseph Fourier University) "Role of elastic fiber components in the vascular physiology. Signaling induced by elastic fiber components in vascular cells" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Suneel Apte (Lerner Research Institute) "ADAMTS regulation of the extracellular matrix" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
9:30 pm | Informal Discussion in the Pub |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation of Elastic Fiber Gene Expression |
9:00 am - 9:05 am | Introduction by Discussion Leader: Bob Mecham (Washington University School of Medicine) |
9:05 am - 9:30 am | Joel Rosenbloom (University of Pennsylvania School of Dental Medicine)
"A retrospective on elastin and the elastic fiber" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Markus J. Buehler (MIT)
"Mechanics and failure of fibrous protein materials in extreme physiological conditions and disease" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Branka Dabovic (NYU Medical Center)
"Multiple roles for LTBP" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:15 am | John Couchman (University of Copenhagen)
"Syndecan proteoglycans: signaling in cell adhesion and matrix assembly" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Philip Trackman (Boston University School of Medicine)
"Lysyl oxidase pro-peptide function" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | Poster Highlights: speakers selected from posters |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (continued) |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | Cell Signaling and the Elastic Fiber |
7:30 pm - 7:40 pm | Introduction by Discussion Leader: Lynn Sakai (Shriners Hospital for Children) |
7:40 pm - 8:00 pm | Lynn Sakai (Shriners Hospital for Children) "Microfibril structure and growth factor signaling in two new Fbn1 mutant mouse models" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Clarissa Craft (Washington University School of Medicine) "Altered signaling in MAGP KO mice" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Daniel Bax (University of Sydney) "Integrin alphaVbeta3 mediated cell adhesion to tropoelastin" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm | Informal Discussion in the Pub |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Elastic Fibers and Vascular Development |
9:00 am - 9:05 am | Introduction by Discussion Leader: Giorgio Bressan (University of Padua) |
9:05 am - 9:25 am | Brenda Rongish (University of Kansas Medical Center) "Morphogenesis" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Giorgio Bressan (University of Padua) "Emilin family" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Hiromi Yanagisawa (UT Southwestern) "Fibulin" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Virginie Mattot (CNRS) "Regulation of vascular elastogenesis" |
11:20 am - 11:25 am | Discussion |
11:25 am - 12:30 pm | Poster Highlights: speakers selected from posters |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Disorders and Disease |
7:30 pm - 7:35 pm | Introduction by Discussion Leader: Zsolt Urban (Washington University School of Medicine) |
7:35 pm - 7:55 pm | Zsolt Urban (Washington University School of Medicine) "Novel genes for cutis laxa" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Jouni Uitto (Jefferson Medical College) "PXE: molecular diagnostics and putative pathomechanisms" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:40 pm | Limin Gong (University of Texas) "Increased proliferative potential of Tsc2+/- smooth muscles cells; suppression by rapamycin and alpha-elastin peptides" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Mark Lindsay (Johns Hopkins University) "Novel disease mechanisms and therapeutic strategies in Marfan syndrome" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Adrian Shifren (Washington University School of Medicine) "Genetic control of elastic fiber repair" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Informal Discussion in the Pub |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | Therapeutic Advances and Elastic Tissues |
9:00 am - 9:10 am | Introduction by Discussion Leader: Rich Pierce (Washington University School of Medicine) |
9:10 am - 9:30 am | Rich Pierce (Washington University School of Medicine) "Elastin reexpression with injury" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Bela Suki (Boston University) "ECM and lung mechanical behavior" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Rae Yeung (University of Toronto, Canada) "MMP9 destruction of elastin in Kawasaki disease" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:15 am | John Curci (Washington University School of Medicine) "Managing elastin destruction in abdominal aortic aneurysms" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Marlene Rabinovitch (Stanford University) "Elastic fiber pathobiology in pulmonary hypertension" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | Poster Highlights: speakers selected from posters |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (continued) |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | New Advances in Elastogenic Tissue Repair: Biomaterials and Bioengineering |
7:30 pm - 7:35 pm | Introduction by Discussion Leader: Fred Keeley (University of Toronto) |
7:35 pm - 7:55 pm | Fred Keeley (University of Toronto) "Reassembling a simplified elastin as a biomaterial" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Nancy Forde (Simon Fraser University) "Probing the molecular basis for elasticity using optical tweezers" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:55 pm | Steven Wise (University of Sydney) "Elastin vascular conduits" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Willeke Daamen (Radboud University Nijmegen Medical Centre) "Elastin-containing scaffolds for molecular tissue engineering" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Informal Discussion in the Pub |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |