SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Biogenesis and Function of Elastic Fibers |
| Discussion Leader: Elaine Davis (McGill University) |
7:40 pm - 7:45 pm | Elaine Davis (McGill University) "Introduction" |
7:45 pm - 8:05 pm | Fred Keeley (Hospital for Sick Children, Toronto, Canada) "Elastic Fiber Evolution: Where have we come in past 200 million years?" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Elaine Davis (McGill University) "Elastic Fiber Assembly: What have we learned in past 20 years?" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Tomoyuki Nakamura (Kansai Medical University, Japan) "Fibulins: What have we discovered in the past 2 years?" |
9:05 pm - 9:15 pm | Discussion |
9:05 pm - 9:30 pm | General Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biogenesis and Function of Microfibrils |
| Discussion Leaders: Dieter Reinhardt (McGill University) and Cay Kielty (University of Manchester) |
9:00 am - 9:05 am | Cay Kielty (University of Manchester) and Dieter Reinhardt (McGill University) "Introduction" |
9:05 am - 9:20 am | Cay Kielty (University of Manchester, UK) "Cell surface interactions in microfibril and elastic fiber formation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Sacha Jensen (University of Oxford, UK) "Structure of fibrillin-1 N-terminus" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:25 am | Coffee Break |
10:25 am - 10:40 am | Suneel Apte (Cleveland Clinic) "ADAMTSL4 in fibrillin assembly" |
10:40 am - 10:50 am | Discussion |
10:50 am - 11:05 am | Dieter Reinhardt (McGill University) "Critical requirements for fibrillin-1 assembly" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Jean Schwarzbauer (Princeton University) "Fibronectin assembly" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Lynn Sakai (Shriners Hospital for Children, Portland) "Microfibril mediated BMP and TGF-beta signaling" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:30 pm | 2 poster highlights to be selected |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Elastic Fiber-Mediated Cell Signaling |
| Discussion Leader: Lynn Sakai (Shriners Hospital for Children, Portland) |
7:30 pm - 7:45 pm | Silvia Smaldone (MSSM) "Stem Cells and Fibrillins" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:10 pm | Branka Dabovic (NYUMC, NY) "Dual Functions of LTBP-4; Matrix organizer and Growth Factor Regulator" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Bart Loeys (Univ. Ghent, Belgium) "TGF beta signaling in aneurysmal disease" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Hiromi Yanasigawa (UTSW, USA) "Is TGF beta a culprit in aneurysms resulting from the loss of fibulin-4?" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Clarissa Craft (Washington University, St. Louis, USA) "Utilizing the MAGP1-/- mouse to understand the role of microfibrils in maintaining bone quality" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Elastic fibers in the vasculature, development, disorders and therapies |
| Discussion Leaders: Marlene Rabinovitch (Stanford University) and Bob Mecham (Washington University) |
9:00 am - 9:25 am | Mark Majesky (Univ. N.C, USA) "State of the Art: Development of the Blood Vessel Wall" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Seema Mital (Hospital for Sick Children in Toronto) "Pluripotent stem cell derived models of Williams syndrome" |
9:55 am - 10:05 am | Discussion |
10:05 am-10:30 am | Coffee Break |
10:30 am - 10:50 am | Linda Harris (UK) "Elastase-MMP-12, Trophoblasts and Spiral Artery Remodeling" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Marlene Rabinovitch (Stanford) "Smooth muscle cell production of neutrophil elastase" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Alec Hinek (University of Toronto) "Old drugs for new treatment of cardiovascular diseases associated with the impaired elastogenesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster highlights and discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetic Basis and Treatment of Diseases of Elastic Fibers |
| Discussion Leader: Zsolt Urban (Univ. of Pittsburgh) |
7:30 pm - 7:50 pm | Zsolt Urban (University of Pittsburgh, Pittsburgh, Pennsylvania) "Defects of elastic fiber synthesis and TGFβ signaling in cutis laxa" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Jennifer Habashi (Johns Hopkins University) "Non-canonical TGFβ signaling in Marfan syndrome" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Beth Kozel (Washington University) "Genetic Modifiers of Elastin Haploinsufficiency" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Luis Perez-Jurado (Universitat Pompeu Farba) "Losartan trial for Williams syndrome" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Elastic fibers in lung development, disease and aging |
| Discussion Leaders: Tom Mariani (Univ. of Rochester) and Dick Bland (Stanford University) |
9:00 am - 9:25 am | Steve McGowan (Univ. of Iowa, USA) "Developmental regulation elastin expression and elastogenic progenitors" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Dick Bland (Stanford University) "Inhibition of lung elastase activity blunts inflammation and enables lung growth during mechanical ventilation of newborn mice" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break / Group Photo |
10:30 am - 10:55 am | Rory Morty (Justus Liebig University, Giessen, Germany) "Elastic fiber remodeling in neonatal chronic lung disease" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Anne Perl (University of Cincinnati College of Medicine) "Elastogenic progenitors in lung regeneration" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Bela Suki (Boston University)
"Dynamics of Enzymatic Digestion of Elastic Fibers and Networks Under Tension" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Abstract presentation |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 3 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Elastic Fibers in Dermal Development, Disease and Aging |
| Discussion Leader: Jouni Uitto (Jefferson Medical College, Philadelphia) |
7:30 pm - 7:40 pm | Joel Rosenbloom (Jefferson Medical College, Philadelphia) "Introduction: Elastic Fibers in the Skin- What’s Different?" |
7:40 pm - 8:05 pm | Jouni Uitto (Jefferson Medical College, Philadelphia) "Pathomechanisms of Ectopic Mineralization of Elastic Fibers in the Skin" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Qiaoli Li (Jefferson Medical College, Philadelphia) "Morpholino Mediated Down Regulation of Elastin in Zebrafish Model System" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Jeffrey Davidson (Vanderbilt University) "Cutaneous Aging and Premature Aging Syndromes - The Role of Elastic Fibers" |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Molecular properties of elastin and elastin-based polymers |
| Discussion Leader: Feed Keeley (Univ. Toronto Hospital for Sick Kids) and Daniela Qualigno (University of Modena) |
9:00 am - 9:25 am | Clair Baldock (University of Manchester, UK) "Nanostructure and elastic properties of human tropoelastin" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Ashutosh Chilkoti (Duke University) "Tuneable self-assembly properties of elastin-like polymers" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Lisa Muiznieks (Hospital for Sick Children, Toronto, Canada) "Effect of proline spacing and beta strand formation on assembly and physical properties of elastin" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Brigida Bochicchio (University of Basilicata, Italy) "Structural, mechanical and biological studies on a chimeric resilin-, elastin-, and collagen-like engineered polypeptide" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | John Parkinson (Univ. of Toronto, Hospital for Sick Children, Toronto, Canada) "Polymorphisms affecting structure and function of human tropoelastin" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 4 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Elastic fiber-based tissue engineering |
| Discussion Leaders: Tony Weiss (University of Sydney, Australia) and Katja Schenke-Layland (Fraunhofer IGB Stuttgart and University of Tübingen, Germany) |
7:30 pm - 7:50 pm | Laura Niklason (Yale University) "Lung tissue engineering" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Willeke Daamen (Radboud University, the Netherlands) "Collagen and elastin biomaterials in regenerative medicine" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Tony Weiss (University of Sydney, Australia) "Tropoelastin-based tissue repair constructs" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Katja Schenke-Layland (Fraunhofer IGB Stuttgart and University of Tübingen, Germany) "Visualizing elastic tissue development - stretching our technology and paradigms" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |