| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Molecular properties and assembly of elastin |
| 7:40 pm - 7:45 pm | Discussion Leaders: Clair Baldock (University of Manchester, United Kingdom) and Anthony Weiss (University of Sydney, Australia)
"Introduction"
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| 7:45 pm - 8:05 pm | Anthony Weiss (University of Sydney, Australia)
"Supramolecular stages in elastogenesis"
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| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:30 pm | Fred Keeley (The Hospital for Sick Children, Toronto, Canada)
"Molecular assembly of elastin: little things mean a lot"
|
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:55 pm | Tomo Nakamura (Kansai Medical University, Japan)
"TGFbeta-independent role of LTBPs and Fibulin-5 in elastic fiber assembly"
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| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Markus Buehler (Massachusetts Institute of Technology, USA)
"Lessons from molecular modeling of spider silk"
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| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Microfibrils and associated proteins |
| 9:00 am - 9:05 am | Discussion Leaders: Robert Mecham (Washington University, St. Louis, USA) and Dirk Hubmacher (Lerner Research Institute, Cleveland Clinic, USA)
"Introduction"
|
| 9:05 am - 9:25 am | Steven Bassnett (Washington University, St. Louis, USA)
"Development of the ocular zonule and the role of fibrillins in the eye"
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| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Sacha Jensen (University of Oxford, United Kingdom)
"New insights into fibrillin interactions from Marfan and acromelic dysplasia mutants"
|
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Francesco Ramirez (Mount Sinai Hospital, New York, USA)
"New roles of fibrillin-1 in homeostasis"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Jeroen Essers (University of Rotterdam, Netherlands)
"Consequences of impaired elastogenesis in Fibulin-4 deficient mice"
|
| 11:20 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Cay Kielty (University of Manchester, United Kingdom)
"Cellular regulation of microfibril assembly"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Anna Tarakanova (Massachusetts Institute of Technology, USA)
"Elastic network model of tropoelastin implicates bridge region in assembly and cell-binding" |
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Lauren Wang (Cleveland Clinic, Lerner Research Institute)
"Non-selective assembly of fibrillin microfibrils in the rodent ocular zonule and in vitro: Implications for Marfan syndrome" |
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Novel approaches for elastic system analysis |
| Discussion Leaders: Brenda Rongish (University of Kansas Medical Center, USA) and John Parkinson (University of Toronto, Canada)
|
| 7:30 pm - 7:45 pm | Kristin Kumashiro (University of Hawaii, USA)
"Putting a new spin on elastin structure-function with solid-state NMR spectroscopy"
|
| 7:45 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:10 pm | Christian Schmelzer (Martin Luther University Halle-Wittenberg, Germany)
"Monitoring aging in elastic fibers"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:35 pm | Zeev Smilansky (Anima Cell Metrology, USA)
"Monitoring the synthesis of elastin (and other proteins) in living cells using fluorescent labeled tRNA pairs"
|
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Steve Jupe (REACTOME Consortium)
"Elastic Fiber representation in REACTOME, a database of biological pathways"
|
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Paul Coucke (Ghent University, Belgium)
"An efficient strategy for the screening of genes involved in elastinopathies using Next Generation Sequencing technology"
|
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Elastic fiber-related cell signaling in health and disease |
| 9:00 am - 9:05 am | Discussion Leaders: Lynn Sakai (Shriners Hospital for Children, Portland, USA) and Bart Loeys (University of Antwerp, Belgium)
"Discussion"
|
| 9:05 am - 9:25 am | Tim Springer (Harvard Medical School, Boston, USA)
"Revealing differences between the pro-forms of BMP9 and TGF-beta"
|
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Bart Loeys (University of Antwerp, Belgium)
"TGF-beta signaling in aortic aneurysmal disease"
|
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:30 am | Group Photo / Coffee Break |
| 10:30 am - 10:50 am | Boris Hinz (University of Toronto, Canada)
"When elasticity is lost - the role of myofibroblasts in fibrosis"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Lynn Sakai (Shriners Hospital for Children Portland, USA)
"Integration of Notch and BMP signaling pathways by fibrillin microfibrils"
|
| 11:20 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Elizabeth Gerber (Johns Hopkins University School of Medicine, Baltimore, USA)
"Stiff skin syndrome: A fibrillinopathy reveals a role for integrins in skin fibrosis"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Jenni Tamminen (University of Helsinki, Finland)
"Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug" |
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Selen Catania (University of Maryland, USA)
"LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1" |
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Functionalization of the elastic fiber/microfibril system |
| 7:30 pm - 7:35 pm | Discussion Leaders: Dan Rifkin (NYU Langone Medical Center, New York, USA) and Katri Koli (University of Helsinki, Finland)
"Introduction"
|
| 7:35 pm - 7:55 pm | Gerhard Sengle (University of Cologne, Germany)
"Regulation of BMP signaling by fibrillin microfibrils"
|
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Dan Rifkin (NYU Langone Medical Center, New York, USA)
"Reversal of elastin-related phenotypes in LTBP deficient mice"
|
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Dirk Hubmacher (Lerner Research Institute, Cleveland Clinic, USA)
"A new mouse model for human geleophysic dysplasia and functional relationship between ADAMTSL2 and Fibrillin-1"
|
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | Harald von Melchner (University of Frankfurt Medical School, Germany)
"New insights in LTBP4 deficiency"
|
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Elastic fibers in vascular and lung physiology and remodeling |
| 9:00 am - 9:05 am | Discussion Leaders: Beth Kozel (Washington University, St. Louis, USA) and Hiromi Yanagisawa (University of Texas Southwestern Medical Center, Dallas, USA)
"Introduction" |
| 9:05 am - 9:25 am | Steven Mentzer (Brigham and Women's Hospital, Boston, USA)
"Evidence for stretch-induced post-pneumonectomy lung growth" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Vera Krymskaya (University of Pennsylvania, Philadelphia, USA)
"Lung destruction in rare disease lymphangioleiomyomatosis (LAM): Role of elastin fibers"
|
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Seema Mital (Hospital for Sick Children, Toronto, Canada)
"Williams-Beuren syndrome iPS cells: A platform for drug screening"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Hiromi Yanagisawa (University of Texas Southwestern Medical Center, Dallas, USA)
"Molecular mechanism of aneurysm initiation in Fbln4 mutant mice"
|
| 11:20 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Daniel Greif (Yale University School of Medicine, New Haven, USA)
"Vascular wall in development and disease: progenitor specification, migration and differentiation"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Luuk Te Riet (Erasmus Medical Center, Netherlands)
"Improper elastogenesis drives cardiac pathology" |
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Nancy Ferreira Tojais (Stanford University, USA)
"BMP plays a positive and decorin a negative role in vascular elastin fiber assembly" |
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Elastic fiber diseases and translational aspects |
| 7:30 pm - 7:35 pm | Discussion Leaders: Dianna Milewicz (University of Texas, Medical School, Houston, USA) and Zsolt Urban (University of Pittsburgh, USA)
"Introduction"
|
| 7:35 pm - 7:50 pm | Dianna Milewicz (University of Texas, Medical School, Houston, USA)
"Genetics of thoracic aneurysms and dissections"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:15 pm | Zsolt Urban (University of Pittsburgh, USA)
"Gene discovery in cutis laxa by whole exome sequencing"
|
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:40 pm | Enid Neptune (Johns Hopkins School of Medicine, Baltimore, USA)
"The active matrix in lung homeostasis"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Beth Kozel (Washington University, St. Louis, USA)
"Genetic modifiers of elastin haploinsufficiency"
|
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Yibing Qyang (Yale School of Medicine, New Haven, USA)
"Modeling supravalvular aortic stenosis using induced pluripotent stem cells"
|
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Biomedical engineering and stem cells of elastic systems |
| 9:00 am - 9:05 am | Discussion Leaders: Elliot Chaikof (Harvard Medical School, Boston, USA) and Julia Bujan (University of Alcala, Spain)
"Introduction"
|
| 9:05 am - 9:25 am | Elliot Chaikof (Harvard Medical School, Boston, USA)
"Elastin-mimetic protein polymers"
|
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Yadong Wang (University of Pittsburgh, USA)
"Elastin production in arteries regenerated in situ from synthetic grafts"
|
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Sharon Gerecht (Johns Hopkins University, Baltimore, USA)
"Elastin and fate decision in vascular differentiation"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Anand Ramamurthi (Lerner Research Institute, USA)
"Regenerative elastic matrix repair in abdominal aortic aneurysms"
|
| 11:20 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Ashutosh Chilkoti (Duke University, Durham, USA)
"Moving beyond the hegemony of canonical VPGXG motifs that exhibit coacervation behavior"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Svenja Hinderer (Fraunhofer Institute for Interfacial Engineering and Biotechnology, Germany)
"Upregulation of (tropo-)elastin expression in a 3D dynamic bioreactor system" |
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Gemma Pascual (University of Alcala, Spain)
"Involvement of lysyl oxidases in neointima development in vascular allografts" |
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Emerging topics related to elastic fiber research |
| 7:30 pm - 7:35 pm | Discussion Leaders: Suneel Apte (Lerner Research Institute, USA) and Daniela Quaglino (University of Modena, Italy)
"Introduction"
|
| 7:35 pm - 7:50 pm | Clair Baldock (University of Manchester, United Kingdom)
"3D electron microscopic analysis of elastic fiber associated proteins"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:15 pm | Gaoxiang Ge (Shanghai Institutes for Biological Sciences, Shanghai, China)
"Lysyl Oxidase in Lung Fibrosis and Cancer"
|
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:40 pm | Wanfen Xiong (University of Nebraska Medical Center, USA)
"Early phenotypic changes of vascular smooth muscle cells in response to fibrillin-1 deficiency"
|
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Michelle Combs (Washington University, USA)
"Microfibril-associated glycoprotein 2 (MAGP2) loss-of-function has pleiotropic effects in vivo" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Brian Varisco (Cincinnati Children's Hospital, USA)
"Chymotrypsin-like elastase 1 and elastin remodeling in lung development and regeneration" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Jane Hoover-Plow (Cleveland Clinic Lerner Research Institute, USA)
"EMILIN2, elastin microfibril interface glycoprotein 2, regulates platelet aggregation and platelet TGF-beta1" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
