| Sunday |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Structure and Assembly of Elastin |
| Discussion Leader: Elaine Davis (McGill University, Canada) |
| 7:40 pm - 8:00 pm | Anthony Weiss (The University of Sydney, Australia)
"Tropoelastin: Balancing 3D Structure and Function with Dynamic Assembly" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Brigida Bochicchio (University of Basilicata, Italy)
"Tuning Self-Assembly in Elastin-Derived Peptides and Their Glycoconjugates" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Christian Schmelzer (Martin Luther University Halle-Wittenberg, Germany)
"Mature Elastin Re-Examined: Identification of Inter- and Intramolecular Cross-Links" |
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Elaine Davis (McGill University, Canada)
"Conditional Knockout Mice for Elastin" |
| 9:25 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Microfibrils and Related Molecules |
| Discussion Leader: Lynn Sakai (Oregon Health and Science University, USA) |
| 9:00 am - 9:15 am | Introduction by Discussion Leader |
| 9:15 am - 9:35 am | Clair Baldock (The University of Manchester, United Kingdom)
"Nanoscale Structures of Flexible Elastic Fiber Proteins" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Dirk Hubmacher (Cleveland Clinic Foundation, USA)
"ADAMTS Proteins: Novel Insights into the Formation and Functionalization of Microfibrils" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Sacha Jensen (University of Oxford, United Kingdom)
"Use of a Novel Microfibril Assembly Assay to Study the Pathogenesis of Stiff Skin Syndrome and the Acromelic Dysplasias" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Dieter Reinhardt (McGill University, Canada)
"Fibrillin-1 Interactions with Integrins Guide Cell Functions Through microRNA Regulation" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Francesco Ramirez (Mount Sinai School of Medicine, USA)
"Fibrillin Microfibrils: Sensors and Transducers of Mechanical Forces" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Steven Bassnett (Washington University in St. Louis School of Medicine, USA)
"Composition of the Ciliary Zonule and Its Role in Eye Development" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Rinki Ratnapriya (National Eye Institute, NIH, USA)
"FBN2 and ECM Integrity in Macular Degeneration" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Enzymatic Modification of Elastic Fibers |
| Discussion Leader: Suneel Apte (Cleveland Clinic Lerner Research Institute, USA) |
| 7:30 pm - 7:50 pm | Philip Trackman (Boston University School of Dental Medicine, USA)
"Novel Functions of Lysyl Oxidase Isoforms" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Sandra Wiley (University of California, San Diego, USA)
"Phosphorylation of Secreted Proteins by a New Family of Kinases" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Dieter Jenne (Helmholtz Zentrum Munchen, Germany)
"Elastases and Related Serine Proteases of Neutrophils: Intensifiers of Defense and Destruction" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Brian Varisco (Cincinnati Children's Hospital Medical Center, USA)
"Stretch Regulates Chymotrypsin-Like Elastase 1 Expression and Binding to Lung Elastin in Development and Regeneration" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Sebastien Blaise (Laboratoire SiRMa - UMR MEDyC 7369, France)
"Yin and Yang Effects of Elastin Derived Peptides in Diet-Induced Insulin-Resistant Mice" |
| 9:25 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Cell Signaling and Elastic Fibers |
| Discussion Leader: Daniel Rifkin (New York University, USA) |
| 9:00 am - 9:20 am | Gerhard Sengle (University of Cologne, Germany)
"Extracellular Regulation of Growth Factor Signaling by Fibrillin" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Timothy Springer (Boston Children's Hospital / Harvard Medical School, USA)
"Structural Insights into the Latency and Activation of
TGFβ and BMP Family Members" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Lior Zilberberg (New York University, USA)
"Critical Role for LTBP3 in Marfan Syndrome-Related Thoracic Aortic Aneurysms" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Tomoyuki Nakamura (Kansai Medical University, Japan)
"TGFβ-Independent Functions of LTBPs" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Chi-Ting Su (University of Pittsburgh, USA)
"LTBP4 Regulates TGFβ Receptor Stability" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Nina Kurrle (University of Frankfurt Medical School, Germany)
"Ltbp4 Is a TGFβ1-Dependent Inducer of Pdgfrβ Expression" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Dianaly Au (University of Maryland School of Medicine, USA)
"LRP1 Regulates Vascular Remodeling by Modulating Angiotensin II-Mediated Signaling" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Xing Chen (Peking University, China)
"Optical Activation of TGFβ Signaling by Near-Infrared Light" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Elastic Fibers and Metabolism |
| Discussion Leader: Robert Mecham (Washington University in St. Louis School of Medicine, USA) |
| 7:30 pm - 7:50 pm | Robert Mecham (Washington University in St. Louis School of Medicine, USA)
"MAGP1 and the Microfibrillar Niche: Metabolic Regulation Through TGFβ" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Koen van de Wetering (The Netherlands Cancer Institute, The Netherlands)
"ABCC6 Prevents Connective Tissue Mineralization by Mediating Hepatic ATP Release" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Bert Callewaert (Ghent University Hospital, Belgium)
"Clinical and Genetic Heterogeneity in Neurometabolic Cutis Laxa" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Aleksander Hinek (Hospital for Sick Children, Canada)
"Hormonal Modulation of Elastic Fiber Formation in Human Heart and Skin" |
| 9:20 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Elastic Fibers in Cardiovascular and Pulmonary Disease |
| Discussion Leader: Hiromi Yanagisawa (University of Texas Southwestern Medical Center, USA) |
| 9:00 am - 9:20 am | Hiromi Yanagisawa (University of Texas Southwestern Medical Center, USA)
"Abnormal Mechanosensing and Aortic Aneurysms in Fibulin-4 Mutant Mice" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Julie Phillippi (University of Pittsburgh, USA)
"Elastic Fiber Microarchitecture in Thoracic Aortic Aneurysm Is Predicated by Aortic Valve Morphology" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Gustavo Egea (University of Barcelona School of Medicine, Spain)
"NOX4 Upregulation and Oxidative Stress in Human Patients and Murine Models of Marfan Syndrome" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Naren Vyavahare (Clemson University, USA)
"Nanaoparticle Targeted Drug Delivery to Degraded Elastin in Aneurysms and in Emphysema" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Jessica Wagenseil (Washington University in St. Louis, USA)
"Fibulin-5 in Arterial Mechanics" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Enid Neptune (Johns Hopkins University School of Medicine, USA)
"Novel Strategies for Angiotensin Receptor Modulation in Lung Disease" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Carmen Halabi (Washington University in St. Louis, USA)
"Cardiovascular Manifestations of a Mouse Model of Autosomal Recessive Cutis Laxa Type 1B" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Marjolijn Renard (Center for Medical Genetics, Belgium)
"Influence of Pregnancy on Cardiovascular Disease in Marfan Syndrome" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Translational Research and Genetics of Elastic Fibers |
| Discussion Leader: Beth Kozel (Washington University in St. Louis School of Medicine, USA) |
| 7:30 pm - 7:50 pm | Dianna Milewicz (University of Texas Medical School at Houston, USA)
"The Aortic Smooth Muscle Cell Elastin-Contractile Unit and Thoracic Aortic Disease" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Stephanie Ware (Indiana University School of Medicine, USA)
"Lessons from Syndromic and Non-Syndromic Pediatric Thoracic Aortic Aneurysm" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Christina Gurnett (Washington University in St. Louis, USA)
"A Polygenic Burden of Rare Variants in Extracellular Matrix Genes Among Individuals with Adolescent Idiopathic Scoliosis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Beth Kozel (Washington University in St. Louis School of Medicine, USA)
"Therapeutic Considerations in the Treatment of Elastin Insufficiency" |
| 9:20 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regenerative Medicine and Engineering of Elastic Materials |
| Discussion Leader: Ashutosh Chilkoti (Duke University, USA) |
| 9:00 am - 9:20 am | Ashutosh Chilkoti (Duke University, USA)
"New Intrinsically Disordered Polypeptides that Exhibit Phase Behavior" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | J. Carlos Rodriguez Cabello (University of Valladolid, Spain)
"Elastin-Like Recombinamers: Paving the Way Towards Injectable Artificial ECMs" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Fred Keeley (Hospital for Sick Children, Canada)
"The Making of a Biological Elastomer: Insights from Phylogeny" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:10 am | Anna Tarakanova (Massachusetts Institute of Technology, USA)
"Exploiting Elastin's Mutability: Regulated Sequence Design Through Molecular Simulation" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:25 am | Kristin Kumashiro (University of Hawaii, USA)
"Solid-State NMR Analysis of Elastic Materials" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Katja Schenke-Layland (Fraunhofer IGB Stuttgart, Germany)
"Impact of Elastic Fibers for Heart Valve Tissue Engineering" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Yadong Wang (University of Pittsburgh, USA)
"From Elastomer to Elastin: The Body Does the Transformation" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Directions in Elastic Fiber Research |
| Discussion Leader: Clair Bladock (University of Manchester, United Kingdom) |
| 7:30 pm - 7:50 pm | Daniel Greif (Yale University School of Medicine, USA)
"Aortic Smooth Muscle in Development and Disease: Clonal Architecture and Role of Integrin Beta 3" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Anthony De Tomaso (University of California, Santa Barbara, USA)
"In Vivo Manipulation of ECM Stiffness Induces Anoikis and Vascular Regression in a Basal Chordate" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Michael Sherratt (University of Manchester, United Kingdom)
"Elastic Fiber Associated Proteins as Sacrificial Sunscreens and Antioxidants" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Jiangyu Li (University of Washington, USA)
"Electromechanical Coupling of Elastin" |
| 9:20 pm - 9:30 pm | Discussion |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
