Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Biology of Tissue Elasticity
Discussion Leader: Brigida Bochicchio (University of Basilicata, Italy)
7:40 pm - 8:00 pm
Markus Buehler (Massachusetts Institute of Technology, USA)
"Full Atomistic Modeling of Tropoelastin Structure, Dynamics and Mechanics, and Upscaling to Elastic Fibers"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Anthony Weiss (The University of Sydney, Australia)
"Tropoelastin and Multifunctional Biology"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Kristin Kumashiro (University of Hawaii, USA)
"Molecular-Scale Details of Elastin's Complex and Dynamic Structure"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Jay Humphrey (Yale University, USA)
"Elastin in Central Artery Health and Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Extracellular
Modulation of Cell Signaling
Discussion Leader: Lynn Sakai (Oregon Health and Science University, USA)
9:00 am - 9:20 am
Elizabeth McNally (Northwestern University, USA)
"Latent TGFbeta Binding Protein 4 as a Muscle Disease Modulator"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Pamela Cowin (New York University School of Medicine, USA)
"LTBP1 a Pro-Invasive Factor in Breast Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Zsolt Urban (University of Pittsburgh, USA)
"Fibulin-4a Enhances Vascular and Inhibits Cardiac Progenitor Fate in the Lateral Plate Mesoderm by Inhibiting TGFbeta Signaling"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Gerhard Sengle (University of Cologne, Germany)
"New Mechanisms of BMP Activation Within the Fibrillin Scaffold"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Enid Neptune (Johns Hopkins University School of Medicine, USA)
"Partitioned Signaling Strategies of Angiotensin Receptor Blockade in Emphysema"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Juan Miguel Redondo (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain)
"ADAMTS1 and Nitric Oxide as New Mediators of Aortic Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Dianna Milewicz (McGovern Medical School, University of Texas Health Science Center at Houston, USA) and Elaine Davis (McGill University, Canada)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enabling Technologies for
Elastic Fiber Research
Discussion Leader: Michael Sherratt (University of Manchester, United Kingdom)
7:30 pm - 7:40 pm
Alan Godwin (The University of Manchester, United Kingdom)
"Hierarchical Organisation of Fibrillin from Tissue Structure to Microfibrils"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
Simon Sharpe (Hospital for Sick Children, Canada)
"Structural Studies of Elastin by NMR - From Monomers to Coacervates"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Laurent Debelle (University of Reims Champagne-Ardenne, France)
"Imaging the Arterial Wall: Fluorescence and NanoCT Imaging"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Katja Schenke-Layland (Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Germany)
"Marker-Free Screening of Elastic Fibers and Associated Proteins"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Sacha Jensen (University of Oxford, United Kingdom)
"Use of Genome Editing to Study the Effects of Misfolding Mutants in Fibrillin-1 Domain TB4"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Functional Modifiers of Elastic Fibers
Discussion Leader: Suneel Apte (Cleveland Clinic, USA)
9:00 am - 9:20 am
Laurent Muller (Centre Interdisciplinaire de Recherche en Biologie, INSERM U1050, France)
"Insights into LOXL2 Structure and Vascular Matrix Remodeling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Vivian Lee (Washington University in St. Louis, USA)
"Lysyl Oxidase Mutations in Vascular Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Laurence Denholm (NSW Department of Industry, Australia)
"Congenital Contractural Arachnodactyly (CCA) Inherited as an Autosomal Recessive Marfanoid Disorder Is Associated with a ~58kbp Deletion in the ADAMTSL3 Gene"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Ewa Mularczyk (University of Manchester, United Kingdom)
"ADAMTS10 Mediated Tissue Disruption in Weill Marchesani Syndrome"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Dirk Hubmacher (Cleveland Clinic Lerner Research Institute, USA)
"Limb- and Tendon-Specific Deletion of ADAMTSL2 Results in a Short-Limb Phenotype Mimicking Geleophysic Dysplasia"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Masahiro Saito (Tohoku University, Japan)
"Role of ADAMTSL6beta on the Aortic Aneurysm and Dissection in Marfan Syndrome Mouse Model"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Tomoyuki Nakamura (Kansai Medical University, Japan)
"Essential Function of Fibulin-4 in Lysyl Oxidase Activation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Elastic Fiber Assembly and Composition
Discussion Leader: Hiromi Yanagisawa (University of Tsukuba, Japan)
7:30 pm - 7:50 pm
Sarah Hibbert (University of Manchester, United Kingdom)
"What Are Elastic Tissues Made of: A New Approach to Defining Tissue Proteomes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Tomonobu Ezure (Shiseido Research Center, Japan)
"Subcutaneous Tissue Regulates the Condition of Dermal Layer Matrix via Secretion of Multiple Factors"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Heena Kumra (McGill University, Canada)
"Plasma Fibronectin Acts as a Safeguard in the Vasculature and Supports Synergistic and Differential Roles with Cellular Fibronectin in Vascular Matrix Integrity"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Thinhinane Hocine (MEDyC Laboratory, University of Reims Champagne-Ardenne, France)
"Insulin Resistance Induced by Elastin Fragmentation Promotes Endothelial Impairment and Arterial Hypertension"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Yoshito Yamashiro (University of Tsukuba, Japan)
"The Role of Thrombospondin-1 in Mechanosensing of the Aortic Wall"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Elastic Tissue
Regeneration and Translational Approaches
Discussion Leader: Anthony Weiss (The University of Sydney, Australia)
9:00 am - 9:20 am
Nasim Annabi (Northeastern University, USA)
"Engineering Highly Elastic Surgical Sealants"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Yadong Wang (University of Pittsburgh, USA)
"Arterial Regeneration in Aged Animals"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ashutosh Chilkoti (Duke University, USA)
"Interplay of Order and Disorder Controls Hierarchical Self-Assembly of Partially Structured Elastin Polypeptides"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Brigida Bochicchio (University of Basilicata, Italy)
"A New Member of Chimeric Polypeptide Family Inspired by Elastin-Like Sequences for Tissue Engineering Applications"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Willeke Daamen (Radboud University Nijmegen Medical Centre, The Netherlands)
"Tubular Scaffolds with Shape Recovery Resulting in Radial Elasticity"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Richard Wang (The University of Sydney, Australia)
"Three Dimensional Fabrication of Vasculature with Tropoelastin"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Anand Ramamurthi (Cleveland Clinic, USA)
"JNK-Targeting Nanotherapeutics for Elastic Matrix Regenerative Repair in Abdominal Aortic Aneurysms"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Microfibrillar Proteins and Metabolic Function
Discussion Leader: Daniel Rifkin (New York University, USA)
7:30 pm - 7:50 pm
Atul Chopra (Baylor College of Medicine, USA)
"Asprosin, a Fasting-Induced Glucogenic and Orexigenic Protein Hormone"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Clarissa Craft (Washington University in St. Louis, USA)
"Comparing Fibrillin-1 and MAGP1's Role in Metabolic Health"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Lynn Sakai (Oregon Health and Science University, USA)
"Circulating Fibrillin Fragments in Health and Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Dieter Reinhardt (McGill University, Canada)
"LTBP-4 Structure and Function Is Guided by Fibulin-4"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fibrillinopathies
and Elastin-Related Diseases
Discussion Leader: Beth Kozel (National Heart, Lung, and Blood Institute, NIH, USA)
9:00 am - 9:20 am
Dianna Milewicz (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"Novel Genes and Mechanisms for Thoracic Aortic Dissections"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sanjay Sinha (University of Cambridge, United Kingdom)
"Modeling Marfan Aortic Abnormalities In Vitro Using Induced Pluripotent Stem Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Francesco Ramirez (Icahn School of Medicine at Mount Sinai, USA)
"Systems Pharmacology Approaches Identify Novel Pathways of Arterial Disease in Mice with Marfan Syndrome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mark Levin (National Institutes of Health, USA)
"End Organ Effects of Elastin Insufficiency"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Emanuela Branchetti (University of Pennsylvania, USA)
"RAGE/sRAGE Axis: Novel Biomarker and Mechanism of Thoracic Aortic Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
David Dichek (University of Washington, USA)
"SMC TGF-β Signaling in Aortic Homeostasis and Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lung and
Vasculature Development, Homeostasis and Disease
Discussion Leader: Enid Neptune (Johns Hopkins University School of Medicine, USA)
7:30 pm - 7:50 pm
Farrah Kheradmand (Baylor College of Medicine, USA)
"Autoimmune Mediated Elastin Degradation: Insights from Human Disease and Animal Models"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Elena Gallo MacFarlane (Johns Hopkins University, USA)
"Developmental Underpinnings of Aneurysmal Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jessica Wagenseil (Washington University in St. Louis, USA)
"Mutations in Fibulins and LOX Influence Vessel Mechanics"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Miguel Campanero (Instituto de Investigaciones Biomedicas Alberto Sols, Spain)
"Conditional Deletion of Rcan1 Promotes Aortic Intramural Hematoma that Progresses to Abdominal Aortic Aneurysm"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure