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Elastin, Elastic Fibers and Microfibrils

Gordon Research Conference

Elastic Tissues and Regulation of Cellular Signaling in Development, Homeostasis and Disease

July 23 - 28, 2023

Chair

Vice Chair

Southern New Hampshire University

2500 North River Road

Manchester, New Hampshire, United States

Venue and Travel Information

Conference Description

The Elastin, Elastic Fibers and Microfibrils GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Elastin, Elastic Fibers and Microfibrils" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Elastin Properties and Assembly Discussion Leaders: and
7:40 pm - 8:00 pm	"Extracellular Matrix-Mimetic Fibers: Electrospun Bioconjugates Inspired by Elastin and Hyaluronic Acid"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Cross Linking of Elastin During Elastogenesis"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"Critical Steps in Elastic Fiber Assembly"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Role of N-Linked Glycans in Short Fibulins and LTBP-4 Mediated Matrix Assembly and Function"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Elastin Degradation by Disease Processes Discussion Leaders: and
9:00 am - 9:20 am	"Dynamic Changes Involving Elastic Fiber Genes in Thoracic Aortic Aneurysm and Dissection"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Elastin Breaks, Tears and Splits"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Role of Macrophages in Maintaining and Disrupting the Aortic Wall"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Biomechanics and Transcriptomics of Vascular Aging"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Role of Proteases in The Aorta"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Dynamic Phenotypic Transition of Smooth Muscle Cells during Human Ascending Thoracic Aortic Disease Progression: From Compensation in Aortic Aneurysm to Decompensation in Aortic Dissection"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"The Establishment of the First Reported Zebrafish Model for Thoracic Aortic Dissection and Rupture"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: , and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Structural Roles of Elastin and Microfibril Associated Proteins Discussion Leaders: and
7:30 pm - 7:50 pm	"Elastic Fiber Ultrastructure and Assembly"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Fibrillin-1 Deficiency Impacts the Structural Integrity of Collagen - New Molecular Insight on How to Prevent Aneurysm Formation in Marfan Mice"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"ADAMTS6 Mediated TGFß Activation via LTBPs"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Regional Contributions of The Elastogenic Proteins, Fibulin-4 and Fibulin-5, to Arterial Integrity"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Mechanosensing Through Talin 1 Contributes to Tissue Mechanical Homeostasis"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Signaling in Elastin Rich Tissues Discussion Leaders: and
9:00 am - 9:20 am	"Unanticipated Challenges in Causally Connecting SMC TGF-Beta Signaling With Aortopathy in Mice"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Temporal and Regional Determinants of Hereditary Aneurysm Pathogenesis"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Mechano-Sensing Pathways in the Progression to Aortic Dissection"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Targeting Aortic Aneurysms in a Marfan Mouse Model"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Extracellular Tuning of Vascular Metabolism Leads to Aortic Aneurysm"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Acta2 Contributes to The Altered Elastogenic Machinery of Emphysema"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Cutis Laxa Syndromes: Pathways Underlying A Clinical Classification"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Elastin and Microfibril Modifiers, Assembly, and Development Discussion Leaders: and
7:30 pm - 7:50 pm	"Role of ADAMTS and ADAMTS-like Proteins in Musculoskeletal Development"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Fibrillin-1 Regulation of Cell Signaling and MicroRNAs"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Role of Sphingosine Kinase 1 in Defective Elastin-Induced Hypermuscularization"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Role of Fibrillin in TGFß Latency and Integrin-Mediated Activation"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Correction of Multisystem Smooth Muscle Dysfunction Syndrome in a Mouse Model via Base Editing"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Elastin and Microfibril Matrix: Multi-Omics Approaches Discussion Leaders: and
9:00 am - 9:20 am	"Applying to Computational Methods to Large Datasets to Identify and Characterize Thoracic Aortic Disease"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Multiomics Analyses of Elastin Deficient Aortas"
9:50 am - 10:00 am	Discussion
10:10 am - 10:30 am	"Genome Wide Association Studies for Thoracic Aortic Disease"
10:30 am - 10:40 am	Discussion
10:40 am - 11:10 am	Coffee Break
11:10 am - 11:20 am	"Proteomic Changes in The Aorta With Age"
11:20 am - 11:25 am	Discussion
11:25 am - 11:45 am	"Biomechanical Models of Vascular Integrity"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Leveraging Dynamic Smooth Muscle Cell Phenotype to Identify Critical Regulators of Hereditary Aortopathies"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Coordinated Gene Activity in Pattern Sets (CoGAPs) Identifies The Regional Identity of Aortic Smooth Muscle Cells Across Multiple Single-Cell RNA Sequencing Datasets"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:35 pm	"Energy Metabolism Dynamics in Macrophages of Sporadic Aortic Aneurysms and Acute Dissections"
12:30 pm - 1:30 pm	Lunch
12:35 pm - 12:40 pm	Discussion
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Aortic Structure and Biomechanics in Health and Disease Discussion Leaders: and
7:30 pm - 7:50 pm	"Biomechanical Roles of Compromised Elastic Fiber Integrity in Aortopathy"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"From Cell-Based to Cell-Free Regenerative Treatments for Abdominal Aortic Aneurysm"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Arterial and Aortic Tortuosity as a Biomarker of Aortic Outcomes"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Inactivation of ADAMTS6 Improves Aortic Wall Structure in Mouse Models of Marfan Syndrome"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Critical Role of Endothelial Injury in the Initiation of Aortic Dissection"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Elastic Fibers in Tissue Engineering and Regenerative Medicine Discussion Leaders: and
9:00 am - 9:20 am	"Role of Extracellular Matrix in Biomechanics and its Impact on Bioengineering of Cells and 3D Tissues"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Fabricating Organized Elastin in Vascular Grafts"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Modelling Aortopathies Using Human iPS Cells"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"In situ Elastic Fiber Regeneration to Reverse Cardiopulmonary Disease Conditions by Targeted Nanoparticle Based Therapy"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Arterial ECM Mechanics in Aging and Disease"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Tropoelastin Modulates Mesenchymal Stem Cell Plasticity and Multi-Lineage Differentiation"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"In Vivo Interrogation of Aortic Degeneration using Nanoparticle Contrast-Enhanced CT"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Elastin Structural Integrity with Aging and Environmental Damage Discussion Leaders: and
7:30 pm - 7:50 pm	"Elastin Haploinsufficiency Has Divergent Effects Based on Sex"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Elastin and Elastokines in Health and Aging"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Elastin Calcification Prevention by Matrix Gla Protein"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Extending The Phenotypic Spectrum of Elastin Fiber Disease Through A Gene-First Approach"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"The Regulation of Elastogenesis in the Uterus During Pregnancy"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by 1U13AR080434-01 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and all co-funding support provided by National Heart, Lung and Blood Institute (NHLBI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Elastin, Elastic Fibers and Microfibrils (GRS)

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