| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Elastin and Microfibrillar Proteins: A
History and Future Perspectives |
| Discussion Leaders: Sacha Jensen (University of Oxford, United Kingdom) and Heena Kumra (McGill University, Canada) |
| 3:45 pm - 4:15 pm | Lynn Sakai (Oregon Health and Science University, USA)
"Elastin and Microfibrillar Proteins: A History and Future Perspectives" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Elastin-Associated Proteins and Cell-Matrix Communication |
| Discussion Leaders: Francesco Ramirez (Mount Sinai School of Medicine, USA) and Helen Troilo (University of Manchester, United Kingdom) |
| 7:30 pm - 7:50 pm | Alan Godwin (University of Manchester, United Kingdom)
"A Multilevel Approach to Define the Hierarchical Organisation of Fibrillin Microfibrils" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Alexandra Zuk (University of Cologne, Germany)
"Structural Integrity of Fibrillin Microfibrils Defines the Activation State of Growth Factors" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Yoshito Yamashiro (University of Tsukuba, Japan)
"Abnormal Mechanosensing and Cofilin Activation in Progression of Ascending Aortic Aneurysms in Mice" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Sevinc Alkan (University of Pittsburgh, USA)
"Mutation-Specific TGFβ Signaling Changes in Patients with ELN-Related Cutis Laxa" |
| 9:20 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Mentorship Component: Finding and Establishing a Successful Career |
| Discussion Leaders: Sacha Jensen (University of Oxford, United Kingdom), Christina Papke (University of Texas Southwestern Medical Center, USA), Robert Mecham (Washington University in St. Louis School of Medicine, USA) and Lisa Muiznieks (The Hospital for Sick Children, Canada) |
| 9:00 am - 10:00 am | Panel Discussion |
| "Finding and Establishing a Successful Career" |
|
- Michelle Combs (Quincy University, USA)
- Dianna Milewicz (University of Texas Medical School at Houston, USA)
- Francesco Ramirez (Mount Sinai School of Medicine, USA)
- Gerhard Sengle (University of Cologne, Germany)
|
| Elastin: Structure, Assembly, and Material
Properties |
| 10:00 am - 10:20 am | Chloé Lorion (LBTI UMR5305 CNRS/UCBL, France)
"Development of an Elastin-Like Recombinamer Mimicking Cell Microenvironment" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Pearl Lee (The University of Sydney, Australia)
"Novel Cell Adhesion Regions on Tropoelastin that Mediate Integrin-Directed Cell Surface Interactions" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Advances in Disease Mechanisms, Therapies, and
Industrial Applications |
| Discussion Leaders: Jessica Wagenseil (Washington University in St. Louis, USA) and Giselle Yeo (The University of Sydney, Australia) |
| 1:30 pm - 1:50 pm | Eva Brauchle (Fraunhofer-Institute for Interfacial Engineering and Biotechnology IGB, Germany)
"Analysis of Elastic Fiber Deficiency in Murine Skin Using Raman Microspectroscopy" |
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | Carmen Halabi (Washington University in St. Louis, USA)
"Elastin Insufficiency-Associated Hypertension Is Partially Mediated by Angiotensin II Type 2 Receptor" |
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
