Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Historical and Current Perspectives on Elastic Fiber Function: From Structure to Signaling
Discussion Leaders: Ewa Mularczyk (University of Manchester, United Kingdom) and Rongmo Zhang (McGill University, Canada)
3:45 pm - 4:15 pm
Francesco Ramirez (Icahn School of Medicine at Mount Sinai, USA)
"Historical and Current Perspectives on Elastic Fiber Function: From Structure to Signaling"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structure, Composition and Interactions of Elastic Fiber Components
Discussion Leaders: Willeke Daamen (Radboud University Nijmegen Medical Centre, The Netherlands) and Alexander Eckersley (University of Manchester, United Kingdom)
7:30 pm - 7:45 pm
Jhonsen Djajamuliadi (University of Hawaii at Manoa, USA)
"Investigations of the Unique Role of Alanines in the 'Elastin Puzzle' by Solid-State NMR Spectroscopy and MD Simulations"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Pearl Lee (The University of Sydney, Australia)
"A Cell Adhesive Peptide from Tropoelastin Promotes Sequential Cell Attachment and Spreading via Distinct Receptors"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jingjie Yeo (Massachusetts Institute of Technology, USA)
"Molecular Origins of the Concentration-Dependent Thermal Response in Silk-Elastin-Like Protein Hydrogels: Integrating Experiments and Multiscale Computational Modeling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Mukti Singh (University of Manchester, United Kingdom)
"Structure and Interactions of Elastic Fiber Proteins ADAMTS-L2 and ADAMTS-L4"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Julia Lopez-Guimet (University of Barcelona, Spain)
"Novel Morphological Approaches to Analyse Elastic Laminae Damage in Murine Marfan Syndrome Aortae"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Chelsea Stowell (University of Pittsburgh, USA)
"Pilot Evaluation of an In Situ Tissue Engineered Vascular Graft in the Ovine Arterial Circulation"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Biology of Elastic Fibers and Microfibrils: Implications in Diseases and Therapeutic Potential
Discussion Leaders: Andriy Cherkas (Lviv National Medical University, Ukraine) and Hana Hakami (McGill University, Canada)
9:00 am - 9:15 am
Muthu lakshmi Muthu (McGill University, Canada)
"Therapeutic Potential of Osteoclast Inhibitory Fibrillin-1 Fragments"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Shataakshi Dahal (Lerner Research Institute, Cleveland Clinic, USA)
"Demonstrating Superior Elastin Regenerative Properties of BM-MSC-Derived Smooth Muscle Cells in a 3D Collagenous Milieu"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Miguel A. Ortega (University of Alcala, Spain)
"Chronic Venous Insufficiency in Pregnancy: Its Relation to Remodeling of Placental Villi"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Katrin Hildebrandt (University of Cologne, Germany)
"Microenvironmental Regulation of Muscle Homeostasis by Supramolecular Collagen VI and Fibrillin-2 Networks"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Aneesh Ramaswamy (University of Pittsburgh, USA)
"Improved Aortic Elastogenesis Driven by Adipose-Derived Mesenchymal Stem Cell Secreted Factors"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Kai Li Tan (Baylor College of Medicine, USA)
"Ari-1 and Parkin Affect Nuclear Organization, and ARIH1 Variants Are Associated with Aortic Aneurysm"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: I Got My PhD - Now What?
Discussion Leaders: Heena Kumra (McGill University, Canada) and Michael Lockhart (University of Manchester, United Kingdom)
1:30 pm - 2:30 pm
Panel Discussion
I Got my PhD - Now What?
Julie Phillippi (University of Pittsburgh, USA)
Katja Schenke-Layland (Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Germany)
Silvia Smaldone (Regeneron Pharmaceuticals, Inc., USA)
Anthony Weiss (The University of Sydney, Australia)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
