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Elastin, Elastic Fibers and Microfibrils (GRS)

Gordon Research Seminar

Functions of Elastin and Related Fibers in Development, Homeostasis and Disease

July 22 - 23, 2023
Chairs Muthu Lakshmi Muthu and Kirklann N. Lau
Southern New Hampshire University
2500 North River Road
Manchester, New Hampshire, United States
 Venue and Travel Information

Conference Description

The Elastin, Elastic Fibers and Microfibrils GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

This forum also gives students an opportunity to participate in career panel discussions with established professors. This year’s meeting will focus on topics such as elastic fibers, microfibrils and other proteins involved in elastic fiber formation. Additional topics include elastic tissue mechanics, mechanisms of aging, matrix regulation of cell signaling. An important focus will also be novel approaches and analytical tools for investigating elastin and associated proteins in health and disease, and translational approaches for tissue engineering and regenerative medicine.

Related Meeting

This GRS will be held in conjunction with the "Elastin, Elastic Fibers and Microfibrils" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: The Expanding Roles of Short Fibulins: Elastogenesis and Beyond
Discussion Leader: Mukti Singh (University of Manchester, United Kingdom)
3:45 pm - 4:15 pm
Hiromi Yanagisawa (University of Tsukuba, Japan)
"The Expanding Roles of Short Fibulins: Elastogenesis and Beyond"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structure, Function and Assembly of Elastic Fibers and Microfibrils
Discussion Leader: Iram Fatima Siddiqui (McGill University, Canada)
7:30 pm - 7:45 pm
Michiel Vanhooydonck (Ghent University, Belgium)
"Establishment of The First Zebrafish Model for Thoracic Aortic Dissection and Rupture"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
George Biggin (The University of Manchester, United Kingdom)
"The Role of Fibrillin in Regulating TGFß Bioavailability and Activation"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Grace Ge (NIH, United States)
"A Computational Method to Discover Genes Associated with Elastin Fiber Production via scRNA-seq Analysis and RNAscope"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Likitha Nimmagadda (NIH - NHLBI TVMB, United States)
"Long-Read Transcriptomics Reveals Tissue- and Age-specific Differences in Elastin Isoforms Expression"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Mukti Singh (University of Manchester, United Kingdom)
"Competition Between Fibronectin, Heparin Sulphate and Fibrillin for ADAMTSL2 Binding Suggests A Molecular Mechanism for Microfibril Assembly"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Translational Approaches in Fibrillinopathies and Elastin Related Diseases
Discussion Leader: Yanming Li (Baylor College of Medicine, United States)
9:00 am - 9:15 am
Neha Dinesh (McGill University, Canada)
"Molecular Pathomechanisms of Fibronectin Mutations Leading to Spondylometaphyseal Dysplasia"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Nicholas Kegley (University of Georgia, United States)
"Marfan Syndrome Variants in Fibrillin-1 Exhibit Aberrant O-Glucosylation Within POGLUT2 and POGLUT3 Modification Sites"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Abhijit Chakraborty (Baylor College of Medicine, United States)
"Cytosolic DNA-STING-IRF3 Signaling Drives Epigenetic Induction of Proinflammatory Smooth Muscle Cell Phenotype in Aortic Aneurysms and Dissections"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Samantha Xu (Baylor College of Medicine, United States)
"Transcriptomic Profile of Macrophage-Mediated Energy Metabolism in Sporadic Aortic Aneurysms and Acute Dissections"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Rodrigo Barbosa de Souza (Universidade de Sao Paulo, Brazil)
"Changes in Extracellular Matrix and Vascular Dynamics in The Kidney of The mg?lpn Mouse Model for Marfan Syndrome"
10:35 am - 10:40 am
Discussion
10:40 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Starting Your Career in Science and Research
Discussion Leader: Abhijit Chakraborty (Baylor College of Medicine, United States)
1:30 pm - 2:30 pm
Panel Discussion
Career Mentorship
  • Dieter Reinhardt (McGill University, Canada)
  • Mary Sheppard (University of Kentucky, United States)
  • Silvia Smaldone (Regeneron Pharmaceuticals, Inc., United States)
  • Anna Tarakanova (University of Connecticut, United States)
  • Robert Mecham (Washington University School of Medicine, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes

Contributors

National Institutes of Health (NIH)
Neolastin
Elastrin Therapeutics
International Society for Matrix Biology
Cytoskeleton, Inc.

Funding for this conference was made possible (in part) by 1U13AR080434-01 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and all co-funding support provided by National Heart, Lung and Blood Institute (NHLBI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Elastin, Elastic Fibers and Microfibrils
Additional Fee Info

Elastin, Elastic Fibers and Microfibrils
July 27 - August 1, 2025


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