Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Metabolic Control of Endothelial Cell Function
Discussion Leaders: Ellie Karampini (Sanquin, The Netherlands) and Benjamin Thomson (Northwestern University, USA)
3:15 pm - 3:30 pm
Michael Potente (Max Planck Institute for Heart and Lung Research, Germany)
"Metabolite Signaling in the Endothelium"
3:30 pm - 3:35 pm
Discussion
3:35 pm - 3:45 pm
Maya Chergova (University of Padova, Italy)
"The Mitochondrial Fission Factor Dynamin Related Protein 1 Limits VEGF/VEGFR2 Endocytic Trafficking and Angiogenesis"
3:45 pm - 3:50 pm
Discussion
3:50 pm - 4:00 pm
General Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Signaling Pathways Regulating Endothelial Cell Behavior
Discussion Leaders: Mark Sabbagh (Johns Hopkins University School of Medicine, USA) and Thais Girão-Silva (Heart Institute, University of São Paulo Medical School, Brazil)
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 5:50 pm
Timothy Hla (Harvard Medical School, USA)
"Plasticity of Signaling and Gene Expression in the Endothelium"
5:50 pm - 5:55 pm
Discussion
5:55 pm - 6:05 pm
Kishor Kumar Sivaraj (Max Planck Institute for Molecular Biomedicine, Germany)
"Yap1/Taz Negatively Regulates Bone Angiogenesis and Osteogenesis"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:20 pm
Benjamin Thomson (Northwestern University, USA)
"Dose-Dependent Effects of TEK Signaling on Schlemm's Canal Development and Function"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:35 pm
Mirja Mewes (University Hospital Münster, Germany)
"Effects of the Soluble Adenylyl Cyclase on Endothelial Stiffness, Actin Alterations and Calcium Signals"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Agnes Soos (University of Toronto, Canada)
"Shear Stress-Induced Arterial-Venous Specification of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Pilar Villacampa (Institut d'Investigació Biomédica de Bellvitge (IDIBELL), Spain)
"PI3-Kinase Signalling Regulates Pericyte Maturation During Angiogenesis"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Endothelial Cell Function in the Brain / Mentorship Component: Career Development
Discussion Leaders: Kishor Kumar Sivaraj (Max Planck Institute for Molecular Biomedicine, Germany) and Nicholas Chavkin (University of Virginia, USA)
9:00 am - 9:10 am
Mark Sabbagh (Johns Hopkins University School of Medicine, USA)
"Transcriptional and Epigenomic Landscapes of CNS and Non-CNS Vascular Endothelial Cells"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Brian Chow (Harvard Medical School, USA)
"Unraveling the Mechanism Underlying Neurovascular Coupling and Blood-Brain Barrier"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Alan Tang (University of Pennsylvania, USA)
"Gut Barrier Modulation of Cerebral Cavernous Malformations"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Matthias Rath (Greifswald Medical School, University of Greifswald, Germany)
"CRISPR/Cas9 Genome Editing of CCM3 in Human Endothelial Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Advice from Academic Investigators and Industry Professionals
Michael Potente (Max Planck Institute for Heart and Lung Research, Germany)
Kristy Red-Horse (Stanford University, USA)
Timothy Hla (Harvard Medical School, USA)
Klaus Seuwen (Novartis Institutes for Biomedical Research, Switzerland)
Liudmila Polonchuk (Roche, Switzerland)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Endothelial Cell Specification
Discussion Leaders: Alexandria Afonso (McMaster University, Canada) and Katsuhiro Kato (Max Planck Institute for Molecular Biomedicine, Germany)
1:30 pm - 1:45 pm
Kristy Red-Horse (Stanford University, USA)
"Development of the Coronary Vasculature"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:00 pm
Geoffrey Stanley (Stanford University, USA)
"Single-Cell Analysis of Coronary Progenitors"
2:00 pm - 2:05 pm
Discussion
2:05 pm - 2:15 pm
Gregory Farber (Weill Cornell Medicine, USA)
"ADAM10 Regulates Coronary Vascular Morphology and Development"
2:15 pm - 2:20 pm
Discussion
2:20 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes