2:00-11:00 Arrival and Registration

6:00 PM Dinner

7:30 PM Welcoming Remarks: Conference Chairs
Brent D. Palmer, University of Kentucky
Ana Soto, Tufts University

Envirocrinology: A Rational System for the Study of Disease or Dysfunction in Humans and Ecosystems
John McLachlan – Center for Bioenvironmental Research, Tulane University

7:30 BREAKFAST

9:00 LOW DOSE EFFECTS AND COMPLEX MIXTURES
SESSION CHAIR: Dan Sheehan, National Center for Toxicological Research

9:00 Developmental toxicity of hormonally active chemicals: diethylstilbestrol as an example
Retha Newbold, National Institute of Environmental Health Sciences

9:30 Effects of the soy isoflavone genistein in rodents at exposure levels comparable to those in humans.
Berry Delclos, National Toxicology Program

10:00 Overview of the immunotoxicological evaluation of five endocrine disrupters in the F1 generation of male and female Sprague Dawley rats.
Kimber L. White, Jr., Virginia Commonwealth University

10:30 GROUP PHOTO

11:00 Public health effects of low-dose exposure to endocrine disrupting compounds.
Chris DeRosa, Center for Disease Control

11:30 Xenoestrogens and breast cancer.
Nick Olea, University of Granada, Spain

12:30 LUNCH

6:00 DINNER

7:30 POPULATIONS AS INDICATORS OF ENDOCRINE DISRUPTION
SESSION CHAIR: Glen Fox, Environment Canada

7:30 Daphnia sex ratios, land use and the historical record
Stanley Dodson, University of Wisconsin, Madison

8:00 Influence of altered vitellogenin levels on population biology
Kyle W. Selcer, Duquesne University/Brent Palmer, University of Kentucky

8:30 Can intersex roach reproduce? ... some preliminary answers
Susan Jobling, Brunnel University

9:00 Male breast development, precocious female breast development and environmental factors.
Susan Euling, World Wildlife Fund

7:30 BREAKFAST

9:00 TUESDAY MORNING – Impact of Endocrine Disruptors on Diverse Wildlife
SESSION CHAIR: Gerald LeBlanc, North Carolina State University

9:00 Endocrine strategies: Did invertebrates get it right?
Gerald LeBlanc, North Carolina State University

9:45 Acute and chronic exposure of the hermaphroditic barnacle Elminius modestus to 4-n-nonylphenol and 17ß-oestradiol - ecological relevance?
Zoe Billinghurst, University of Plymouth, UK.

10:30 Break

10:45 Peptide hormonal control of imposex induction in the mudsnail
Pat McClellan-Green, Duke Univ./ Eva Oberdorster, Clemson Univ.

11:30 Alligators and Contaminants - Different Mechanisms and Scales
Louis J. Guillette, Jr., University of Florida

12:30 LUNCH

4:00-6:00 POSTER SESSION I

6:00 DINNER

7:30 TUESDAY EVENING – Novel Targets of Endocrine Disruptors
SESSION CHAIR: F.M. Anne McNabb, Virginia Tech

7:30 PCB effects on thyroid hormone dynamics during development in birds.
F.M. Anne McNabb, Virginia Tech

8:10 PCB effects on thyroid hormone action in the developing brain.
R. Tom Zoeller, University of Massachusetts.

8:50 Effects of 4-nonylphenol and estradiol on parr-smolt transformation in the Atlantic Salmon (Salmo salar).
Scott Brown, Environment Canada

7:30 BREAKFAST

9:00 WEDNESDAY MORNING – Developmental Effects: Our Legacy for the Future
SESSION CHAIR: David Crews, University of Texas

9:00 Introduction and Overview of Developmental Effects of EDCs
David Crews, University of Texas

9:15 Field and laboratory studies of endocrine disruption by heavy metals in wild-life species
Ian P. Callard, Boston University

10:00 BREAK

10:30 Endocrine disruptor effects on GnRH neuronal development
Andrea Gore, Mount Sinai School of Medicine

11:15 Xenoestrogen effects on development of brain and behavior in song birds.
Andrea Erichsen and Michael Fry, UC Davis

12:30 LUNCH

4:00-6:00 POSTER SESSION II

6:00 DINNER

7:30 WEDNESDAY EVENING – Nervous System and Behavioral Impacts
SESSION CHAIR: Paola Palanza, Universita' di Parma, Italy

7:30 Behavior as a target of endocrine disruption.
Paola Palanza, Universita' di Parma, Italy

8:10 Neural and Endocrine Effects of Fish-borne Contaminants.
Richard Seegal, Wadsworth Center

8:50 Perinatal exposure to persistent organochlorine contaminants and cognitive/behavioral development: current findings and future directions.
Paul Stewart, SUNY at Oswego

7:30 BREAKFAST

9:00 LATEST DEVELOPMENTS IN MECHANISMS OF ACTION
SESSION CHAIR: Bruce Blumberg, University of California, Irvine

9:00 SXR and the metabolism of potential EDC
Bruce Blumberg, University of California, Irvine

9:30 Two organochlorine pestides, toxaphene and chlordane, are ligands for ERR alpha-1 orphan receptor.
Shiuan Chen, Chun Yang, and Dujin Zhou. Div. of Immunology, Beckman Res. Inst. City of Hope,

10:00 Sex steroid hormones and their receptors in fish gonads: Potential sites of environmental endocrine disruptors
Yoshitaka Nagahama, National Institute for Basic Biology, Japan

10:30 BREAK

11:00 Acetochlor alters gene expression in amphibian tadpoles in a tissue- and species-specific manner.
Nik Veldhoen1, Graham Van Aggelen2 and Caren Helbing1. 1Department of Biochemistry and Microbiology, University of Victoria, Victoria BC Canada, 2Environmental Toxicology Section, Pacific Environmental Science Centre, BC. Canada.

11:30 Thyroid hormone/thyroid disruptors and brain development: focus on the corpus callosum and myelinogenesis.
Peter Hauser, Baltimore VA Medical Center

12:30 LUNCH

5:00 Business Meeting.

6:00 FAREWELL DINNER

7:30 NEW PARADIGMS IN ENDOCRINE DISRUPTION
SESSION CHAIR: Ana Soto, Tufts University

7:30 Future research directions for low-dose effects and mixtures of EDCs.
Ana Soto, Tufts University.

8:10 The problems of dose and timing of exposure in endocrine disruptor research: Integrating in vitro and in vivo approaches
Fred vom Saal, University of Missouri, Columbia

8:50 Where do traditional epidemiologic methods fail? The need for environmentally sensitive epidemiology
Shana Swan, University of Missouri, Columbia