SUNDAY |
7:30-9:30 pm | Panel Discussion: Evolution, Development and Endocrine Disruptors |
7:30 | Introductory remarks: Ana Soto |
| Discussion leader: Carlos Sonnenschein, Tufts University, Boston, MA |
| Scott Gilbert, Swarthmore College, Swarthmore, PA Ecological Developmental Biology meets the real world. |
| Joe Thornton, Columbia University, New York, NY Evolution of steroid hormone receptors. |
| General discussion |
MONDAY |
8:45 | Photo |
9:00 a.m.-12:30 pm | Dioxins and Development |
| Discussion Leader: Paolo Mocarelli, University Milano-Bicocca, Milan, Italy |
| Jodi A. Flaws, University of Maryland School of Medicine, Baltimore, MD What the Ah knockout teaches us about ovarian physiology. |
| Linda Birnbaum, Environmental Protection Agency, Research Triangle Park, NC Prenatal exposure to dioxins alter the development of the mammary gland. |
| Coffee break |
| Sandra Petersen, University of Massachusetts, Amherst, MA Dioxin and the development of the neuroendocrine system: from genes to behavior. |
| General Discussion: From knockouts to epidemiology: Fleshing out a hypothesis that explains the effects of dioxins. |
7:30-9:30 pm | Perspectives on Endocrine Disruptor Research |
| Discussion Leader: Daniel M. Sheehan |
| Gary Timm, Environmental Protection Agency, Washington, DC A view from EPA |
| Jerry Heindel, National Institute of Environmental Health Sciences, Research Triangle Park, NC A view from NIEHS |
| Willie Owens, Proctor and Gamble, Cincinnati, OH A perspective from industry |
TUESDAY |
8:45 am-12:30 pm | Impact of Endocrine Disruptors on the Male Genital Tract |
| Discussion Leader: Bernard Jegou, Universite de Rennes, France |
| Gen Yamada, Kumamoto University, Kumamoto Japan
Do endocrine disruptors cause hypospadias? Molecular analysis of external genital formation. |
| Rex Hess, University of Illinois, Urbana, IL A role for estrogens in the male reproductive system: the impact of xenoestrogens. |
| Niels Skakkebaeck, University of Copenhagen, Denmark Alterations of the male genital tract and testicular cancer: are they due to endocrine disruptor exposure? |
| Coffee break |
| Luis F. Parada, University of Texas Southwestern Medical Center at Dallas, Dallas, TX A molecular basis for estrogen-induced cryptorchidism. |
7:30-9:30 pm | Mechanisms Underlying the Effects of Xenoestrogens: Receptors and homeobox genes |
| Discussion Leader: George Stancel, University of Texas Health Sciences Center, Houston, TX |
| Sari Mäkelä, University of Turku, Finland The yin and yang of estrogen action |
| Takeshi Kurita, University of California, San Francisco, CA Epithelium-stroma interactions in the development of the female genital tract. |
| David Sassoon, Mount Sinai Medical School Endocrine disruption of homeobox and wnt genes in the female genital tract. |
WEDNESDAY |
9:00 am-12:30 pm | Chemical Mixtures in Endocrine Disruption in Human Populations |
| Discussion Leader: Louis Guillette, University of Florida, Gainsville FL |
| Marieta Fernandez, University of Granada, Granada, Spain Biomarkers of exposure for mixtures and their use to test exposure in humans. |
| Shanna H. Swan, University of Missouri, Columbia MO Can exposure to currently used agricultural chemicals explain rural-urban differences in semen quality? |
| Coffee break |
| Andreas Kortenkamp, The School of Pharmacy, Centre for Toxicology London, England Assessment of the effects of mixtures of xenoestrogens. |
7:30-9:30 pm. | Endocrine Disruptors, Development and Neoplasia |
| Discussion Leader: Annie Sasco, International Agency for Research on Cancer, Lyons France |
| Caroline Markey, Tufts University, Boston, MA Perinatal exposure to low levels of bisphenol-A alters the development of the mouse mammary gland. |
| Retha Newbold, National Institute of Environmental Health Sciences, Research Triangle Park, NC Phytoestrogens as carcinogens |
| General discussion |
THURSDAY |
9:00 am -12:30pm. | Endocrine Disruption in Wildlife |
| Discussion Leader: Anne McNabb, Virginia Polytechnic Institute and State University, Blacksburg VA |
| John G. Burkhart, National Institute of Environmental Health Sciences, Research Triangle Park, NC Complex interactions in aquatic environments associated with amphibian malformations and decline. |
| Susan Jobling, Brunnel University, UK Effects of endocrine disruptors in prosobranch mollusks. |
| Coffee break |
| Gary Ankley, Environmental Protection Agency, Duluth, MN linking endocrine disruption, environmental chemistry and policy using wildlife models. |
7:30-9:30 pm | Disruptors of Thyroid Function |
| Discussion Leader: Tom Zoeller, University of Massachusetts, Amherst, MA |
| Donald Pfaff, Rockefeller University, New York, NY Two modes of estrogen actions in nerve cells and their relation to transcriptional disruption by liganded thyroid hormone receptors. |
| Daniel Doerge, National Center for Toxicological Research, Jefferson, AR Effects of soy isoflavones on thyroid function. |
| Closing Remarks: Ana M. Soto |