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Environmental Endocrine Disruptors

Gordon Research Conference

June 4 - 9, 2006
Chairs Paolo Mocarelli and Rex A. Hess
Vice Chair Shanna Swan
Renaissance Tuscany Il Ciocco
Via Giovanni Pascoli
Lucca (Barga), Lucca, Italy
 Venue and Travel Information

Conference Description

The fifth Gordon Research Conference on Environmental Endocrine Disruptors will be held on June 4-9, 2006 in Il Ciocco, Italy. This conference will bring together a diverse group of scientists for interdisciplinary interaction on this important world-wide topic. This conference will mark the 30th anniversary of the dioxin accident in Seveso, Italy and will therefore spotlight dioxin toxicity in humans and wildlife, but will also bridge the latest sciences through discussions of cell signaling pathways that overlap between endocrine disruptors. Speakers will include leading scientists from the US, Japan and Europe, as well as young scientists who have recently reported exciting findings. Emerging fields, such as epigenetics and computational toxicology, as well as cross-species complexities will receive special attention.

Conference Program

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:30 pmDioxin: 30 years after Seveso
Introductory Remarks: Rex Hess, Co-Chair (University of Illinois, Urbana-Champaign)
7:45 pm - 8:30 pmLinda Birnbaum (US Environmental Protection Agency, RTP, NC, USA)
Complexities of Dioxon toxicity
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmPaolo Mocarelli (University of Milano Bicocca/Hospital of Desio, Italy)
What dioxin taught us as an endocrine disruptor in humans
9:30 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransgenerational endocrine disruption I: epigenetics
9:00 am - 9:30 amDiscussion Leader: John McCarrey (University of Texas at San Antonio, USA)
An introduction to epigenetics
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amJacquetta Trasler (McGill University, Montreal, Canada)
Gamete imprinting defects
10:10 am - 10:15 amDiscussion
10:15 am - 11:00 amCoffee Break / Group Photo
11:00 am - 11:30 amWolf Reik (The Babraham Institute, Cambridge, UK)
Epigenetic reprogramming in mammals
11:30 am - 11:35 amDiscussion
11:35 am - 12:05 pmNoora Kotaja (The Institute of Biomedicine, University of Turku, FINLAND)
Epigenetic cross-talk in environmental endocrine disruption
12:05 pm - 12:10 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmTransgenerational endocrine disruption II: DNA modification and mechanisms
5:30 pm - 5:45 pmDiscussion Leader: Paolo Sassone-Corsi (Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France)
5:45 pm - 6:15 pmMichael K. Skinner (Washington State University, USA)
Epigenetic transgenerational actions of endocrine disruptors
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:50 pmGail Prins (University of Illinois, Chicago, USA)
Bisphenol A induced epigenetic changes in the prostate
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:25 pmFelix Althaus & Françoise Dantzer (University of Zurich, Switzerland)
Other considerations in DNA modification
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndocrine disruption of cell signaling pathways I: Cross talk
9:00 am - 9:15 amDiscussion Leader: Richard Peterson (University of Wisconsin, USA)
9:15 am - 9:45 amChiharu Tohyama (University of Tokyo, Japan)
Molecular mechanism of hormonal disruption by dioxins in offspring of rodents
9:45 am - 9:50 amDiscussion
9:50 am - 10:20 am Michael S. Denison (Environmental Toxicology, University of California, Davis, USA)
Promiscuity in ligand binding and activation of the AHR
Discussion
10:25 am - 11:00 amCoffee Break
11:00 am - 11:30 amShigeaki Kato (University of Tokyo, Japan)
Modulation of estrogen receptor signaling by activated dioxin receptor
11:30 am - 11:35 amDiscussion
11:35 am - 12:05 pmMichael Mancini (Baylor College of Medicine, USA)
Nuclear receptor cofactors and signaling interactions
12:05 pm - 12:10 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pmEndocrine disruption of cell signaling pathways II: Receptor mediated
5:30 pm - 5:45 pmDiscussion Leader: TBA
5:45 pm - 6:15 pmJan-Åke Gustafsson (Karolinska Institutet, Sweden)
Steroid receptors, crosstalk and potential endocrine disruption
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:50 pmMaria Luisa Brandi (University of Florence, Italy)
Colon cancer: a target for estrogen disruption
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:25 pm Peter Thomas (University of Texas at Austin, Port Aransas, Texas, USA)
Membrane estrogen and progestin receptors and endocrine disruptors: from marine biology to breast cancer
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmExperimental and human observations: similarities and differences
9:00 am - 9:15 amDiscussion Leader: Niels Skakkebaek (National University Hospital, Denmark)
9:15 am - 9:45 amRichard Sharpe (The University of Edinburgh, UK)
Environmental oestrogens and androgens in male reproduction
9:45 am - 9:50 amDiscussion
9:50 am - 10:20 amJouko Tuomisto (National Public Health Institute, Finland)
Dioxins and PCBs in the European population: comparisons with experimental data
10:20 am - 10:25 amDiscussion
10:25 am - 11:00 amCoffee Break
11:00 am - 11:30 amVincent Markowski (University of Southern Maine, USA)
Neurobehavioral consequences of prenatal endocrine disruptor exposure
11:30 am - 11:35 amDiscussion
11:35 am - 12:00 pmPanel Discussion
12:00 pm - 12:30 pmOutstanding Trainee Winners Oral Presentations
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session III
5:30 pm - 7:30 pmMetabolic syndrome and endocrine disruption
5:30 pm - 5:45 pmDiscussion Leader: Jerry Heindel (National Institute of Environmental Health Sciences, USA)
Introduction to metabolic syndrome
5:45 pm - 6:15 pm Angel Nadal (Miguel Hernández University, Alicante, Spain)
Diabetes and endocrine disruptors
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:50 pmRetha Newbold (National Institute of Environmental Health Sciences USA)
Developmental exposure to estrogenic compounds and obesity
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:25 pmAlex Odermatt (University of Berne, Switzerland)
Disruption of glucocorticoid action by environmental chemicals: potential development of hypertension and the metabolic syndrome
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNon-monotonic dose-response curves and low-dose effects
9:00 am - 9:15 am Discussion Leader: Frederick S. vom Saal (University of Missouri, USA)
Introduction of low-dose issue and comparison with hormesis
9:15 am - 9:45 amWade Welshons (University of Missouri, USA)
Clinical application of Low-Dose and Inverted-U Dose-Responses
9:45 am - 9:50 amDiscussion
9:50 am - 10:20 amAndreas Kortenkamp (University of London, UK)
Low-dose interactions of xenobiotics with a common mode of action
10:20 am - 10:25 amDiscussion
10:25 am - 11:00 amCoffee Break
11:00 am - 11:30 amAna Soto (Tufts University School of Medicine, Boston, USA)
Low dose bisphenol-A alters peripubertal mammary gland development in mice
11:30 am - 11:35 amDiscussion
11:35 am - 12:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session IV
5:30 pm - 6:45 pmStem cells and endocrine disruptor toxicology
5:30 pm - 5:45 pmDiscussion Leader: John McLachlan (Tulane University, USA)
Introduction to stem cells and endocrine disruptors. Stem cells and pluripotential utilization in toxicology
5:45 pm - 6:20 pmDavid Hay (Roslin Institute, UK)
Embryonic stem cells and developmental/endocrine disruptors
6:20 pm - 6:45 pmDiscussion
6:45 pm - 7:30 pmSynopsis and new issues in endocrine disruptor research
6:45 pm - 7:10 pmLouis J. Guillette, Jr. (University of Florida, USA)
7:10 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

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Additional Fee Info

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