Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						
7:40 pm - 9:30 pm 
	
Keynote Session: Enzymes in Signaling Pathways 
 
 
 
						
7:40 pm - 7:45 pm 
	
Introduction by Discussion Leader
 
 
						
7:45 pm - 8:15 pm 
	
"Illuminating the Biochemical Activity Architecture of the Cell" 
 
 
 
						
8:15 pm - 8:20 pm 
	
Discussion
 
 
						
8:20 pm - 8:50 pm 
	
"The Many Guises of Reactive Metabolite Signaling" 
 
 
 
						
8:50 pm - 8:55 pm 
	
Discussion
 
 
						
8:55 pm - 9:25 pm 
	
"AI for Understanding Enzyme Function and for Pedicting the Effects of Missense Mutations on Biochemical Activity" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Unlocking New Potential in Natural Products 
 
 
 
						
9:00 am - 9:30 am 
	
"Exploring Reaction Diversity of Mononuclear Non-Heme Iron Enzymes and Beyond" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"The Fascinating Enzymes of Riboflavin Biosynthesis" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Group Photo / Coffee Break
 
 
						
10:50 am - 11:00 am 
	
Short Talk Selected from Poster Abstracts
 
 
						
11:00 am - 11:05 am 
	
Discussion
 
 
						
11:05 am - 11:35 am 
	
"Exploring SAM-Consuming Enzymes: Methyltransferases and Radical SAM Enzymes" 
 
 
 
						
11:35 am - 11:45 am 
	
Discussion
 
 
						
11:45 am - 11:55 am 
	
Short Talk Selected from Poster Abstracts
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
Short Talk Selected from Poster Abstracts
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
Short Talk Selected from Poster Abstracts
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Decoding Post-Translational Modifications 
 
 
 
						
7:30 pm - 8:00 pm 
	
"Advancing Drug Discovery by Targeting Protein Tyrosine Dephosphorylation" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:40 pm 
	
"Enzymatic Swiss Army Knives for Peptide Backbone Modifications" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"Paradoxes of Protein SUMOylation: A Role for Biomolecular Condensates?" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Dynamics and Kinetics: Bridging Time, Motion, and Function 
 
 
 
						
9:00 am - 9:30 am 
	
"Kinetics and Mechanism of Retrotransposon Replication of RNA Affording Efficient, Site-Specific Insertion of Large Genes" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Using Statistical Structural Biology to Understand Enzymes" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:30 am 
	
Short Talk Selected from Poster Abstracts
 
 
						
10:30 am - 10:35 am 
	
Discussion
 
 
						
10:35 am - 11:05 am 
	
Coffee Break
 
 
						
11:05 am - 11:35 am 
	
"Nature's Switches: Harnessing Environmental Signals to Control Enzymatic Activity" 
 
 
 
						
11:35 am - 11:45 am 
	
Discussion
 
 
						
11:45 am - 11:55 am 
	
Short Talk Selected from Poster Abstracts
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
Short Talk Selected from Poster Abstracts
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
Short Talk Selected from Poster Abstracts
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Innovative Paths in Enzyme-Driven Catalysis 
 
 
 
						
7:30 pm - 8:00 pm 
	
"Remarkable New Enzymology Involved in the Biosynthesis of the Thiamin Pyrimidine" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:40 pm 
	
"Giant Marine Enzymes in Giant Toxin Assembly Line Biosynthesis" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"Design Principles for Rieske Chemistry" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Unlocking Therapeutic Potential of Enzyme Inhibition in Drug Development 
 
 
 
						
9:00 am - 9:30 am 
	
"Allosteric Activation of Metabolic Pathways as a Novel Antibiotic Strategy" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Bullet Time: MAT Isoform Selectivity Through Allosteric Braking" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:00 am 
	
Short Talk Selected from Poster Abstracts
 
 
						
11:00 am - 11:05 am 
	
Discussion
 
 
						
11:05 am - 11:35 am 
	
"MOPEDâ„¢: A Novel Platform for the Discovery of Molecular Glues" 
 
 
 
						
11:35 am - 11:45 am 
	
Discussion
 
 
						
11:45 am - 11:55 am 
	
Short Talk Selected from Poster Abstracts
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
Short Talk Selected from Poster Abstracts
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
Short Talk Selected from Poster Abstracts
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Code Meets Catalysis: Exploring Computational Enzymology 
 
 
 
						
7:30 pm - 8:00 pm 
	
"Protein Functional Motion Prediction Led by Long Timescale Molecular Dynamics" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:40 pm 
	
"Long-Range Radical Transport in Ribonucleotide Reductase" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"AI Protein Profiling (AiPP) for Proteome-Wide Discovery of Druggable Pockets and Ligandable Cysteines" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s) 
 
 
						
9:00 am - 12:30 pm 
	
Unlocking Data with Machine Learning in High-Throughput Assays 
 
 
 
						
9:00 am - 9:30 am 
	
"Learning the Protein Structure Distribution with Ambient Diffusion" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Leveraging Evolutionary-Scale Enzymology to Map and Predict Catalytic Landscapes" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:30 am 
	
Short Talk Selected from Poster Abstracts
 
 
						
10:30 am - 10:35 am 
	
Discussion
 
 
						
10:35 am - 11:05 am 
	
Coffee Break
 
 
						
11:05 am - 11:35 am 
	
"Programmable Modulators of Conformationally Diverse Target Substrates via Generative Language Models" 
 
 
 
						
11:35 am - 11:45 am 
	
Discussion
 
 
						
11:45 am - 11:55 am 
	
Short Talk Selected from Poster Abstracts
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
Short Talk Selected from Poster Abstracts
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
Short Talk Selected from Poster Abstracts
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Keynote Session: Unusual Chemistry Carried Out by Enzymes 
 
 
 
						
7:30 pm - 8:15 pm 
	
"Mechanistic Studies of Unusual Biosynthetic Enzymes" 
 
 
 
						
8:15 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 9:15 pm 
	
 
 
						
9:15 pm - 9:30 pm 
	
Discussion
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure