| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Enzyme Inhibition and Drug Design |
| Discussion Leader: Zhen Wang (Albert Einstein College of Medicine, USA) |
| 3:45 pm - 4:15 pm | Thomas Meek (Texas A&M University, USA)
"Rational Design of Enzyme Inhibitors as a Last Resort for Drug Discovery" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Learning from Nature: How Enzymes Work |
| This session focuses on fundamental aspects of enzyme mechanisms. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts. |
| Discussion Leader: Tatiana Mishanina (University of Wisconsin-Madison, USA) |
| 7:30 pm - 7:50 pm | Jonathan Musila (Auburn University, USA)
"FMN Reductase of Alkanesulfonate Monooxygenase System: Role of pi-Helix and Flavin-Induced Oligomeric Switch" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Svetlana Kholodar (University of Iowa, USA)
"Challenging the Traditional Mechanism of Thymidylate Synthase" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Evan Judd (Novartis Institutes for BioMedical Research, USA)
"How Does a Chromatin Remodeler Move? Investigating How Accessory Domains Tune the Function of BRM/BRG1" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Kanishk Kapilashrami (Memorial Sloan Kettering Cancer Center, USA)
"Kinetic Isotope Effects Uncover Transition States of Protein Lysine Methyltransferases" |
| 9:20 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Pushing the Limits: Applications of Enzymology and Studies of Metabolic Pathways |
| This session focuses on applications of knowledge learned by studying enzymes and metabolic pathways. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts. |
| Discussion Leader: Myles Poulin (Albert Einstein College of Medicine, USA) |
| 9:00 am - 9:20 am | Juliana Martinez (Florida State University, USA)
"Allokairic Regulation of Enzyme Function" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Shijie Huang (University of New Mexico, USA)
"In Vivo Detection and Quantification of Ribosome Inhibition and Directed Evolution of Ribosomal RNA Variants" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Romila Mascarenhas (Loyola University Chicago, USA)
"Elucidating the Mechanism of Inactivation of PLP Dependent Drug Targets – Ornithine Aminotransferase and GABA Aminotransferase, and Comparison with a Non-Drug Target-Asp-AT" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Ken Ellens (University of Luxembourg, Luxembourg)
"CLYBL as a Missing Piece of the Metabolite Repair Puzzle" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Leverage Your Scientific Training to Find Your Dream Career |
| This session serves as the career development discussion panel of the conference. The panelists include junior and veteran investigators in academia and industry, as well as experts in non-traditional careers. They will discuss different career paths, offer advice on career development, and answer questions from conference attendees. |
| Discussion Leader: Crystal Smitherman (Aalto Scientific, Ltd., USA) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Academia, Industry, and Alternative Career Paths" |
|
- Squire Booker (Pennsylvania State University, USA)
- Lauren Celano (Propel Careers, USA)
- Catherine Goodman (Journal of Biological Chemistry, USA)
- Randy Kipp (Relay Therapeutics, USA)
- Thomas Meek (Texas A&M University, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
