Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Evolution of Enzyme Catalysis and Regulation
Discussion Leader: Tatiana Mishanina (University of Wisconsin-Madison, USA)
3:45 pm - 4:15 pm
Dorothee Kern (Howard Hughes Medical Institute / Brandeis University, USA)
"Recreating the Evolution of Enzyme Catalysis and Regulation over Several Billion Years"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Interdisciplinary Approaches to Enzymology
This session focuses on taking a look at enzymes from different angles to understand how they work, using a variety of techniques ranging from classical kinetic and labeling methods to computer simulations to imaging. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts.
Discussion Leader: Danica Cui (Yale University, USA)
7:30 pm - 7:45 pm
Vidhi Pareek (Pennsylvania State University, USA)
"Catching a Metabolon in Action: 3D Chemical Imaging of Single Cells by Secondary Ion Mass Spectrometry to Study Purinosomes"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Shi Chen (Memorial Sloan Kettering Cancer Center, USA)
"Integrated Experimental-Computational Approaches Elucidate Dynamic Conformational Landscapes of SETD8"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Graeme Howe (University of Illinois at Urbana-Champaign, USA)
"Secondary 18 O Kinetic Isotope Effects as Evidence Against a Reverse Protonation Mechanism on Phosphite Dehydrogenase"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Yumeng Liu (Marquette University, USA)
"Allosteric Regulation of Pyruvate Carboxylase"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Filip Yabukarski (Stanford University, USA)
"From 'Structure–Function' to 'Ensemble–Function' Relationships: A Paradigm for Interpretation of Mutational Effects and Precision in Enzyme Active Sites"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Juan Pan (Pennsylvania State University, USA)
"Mechanism of Oxacyclization Catalyzed by Iron- and 2-Oxoglutarate Dependent Dioxygenase LolO in the Loline Alkaloid Biosynthesis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Enzymes and Metabolic Pathways: From Curiosity to Applications
This session focuses on application of knowledge learned from studying enzymes and metabolic pathways. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts.
Discussion Leader: Tyler Stack (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:15 am
Zane Taylor (Texas A&M University, USA)
"Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni "
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Cecile Petit (University of Toledo, USA)
"Highjacking the Mechanism of GlgE for Tuberculosis Drug Discovery"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Natalie Hendrikse (KTH Royal Institute of Technology, Sweden)
"Exploring Ancestral Sequence Reconstruction as a Strategy for Enzyme Engineering"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Samuel Pellock (University of North Carolina at Chapel Hill, USA)
"Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Maja Klaus (Stanford University, USA)
"Engineering of Modular Polyketide Synthases: Influence of Protein-Protein and Protein-Substrate Interactions"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Steven Fleming (University of North Carolina at Chapel Hill, USA)
"Benchtop Synthesis of Thiopeptides"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Which Road to Take? Perspectives from Scientists in Different Careers
This session serves as a career development discussion panel of the meeting. The panelists include junior and veteran investigators in academia, industry, and science policy. The panelists will share their stories, offer advice on career development, and answer questions from meeting attendees.
Discussion Leader: Michael Funk (Science, AAAS, USA)
1:30 pm - 2:30 pm
Panel Discussion
Perspectives from Scientists in Different Careers
Myles Poulin (University of Maryland, USA)
Alan Rendina (GlaxoSmithKline, USA)
Evan Judd (Agios Pharmaceuticals, USA)
Elizabeth Stulberg (Alliance of Crop, Soil and Environmental Science Societies (ACSESS), USA)
Elizabeth Trimmer (Grinnell College, USA)
Dorothee Kern (Howard Hughes Medical Institute / Brandeis University, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
