Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Evolution of Enzyme Catalysis and Regulation
3:45 pm - 4:15 pm
"Recreating the Evolution of Enzyme Catalysis and Regulation over Several Billion Years"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Interdisciplinary Approaches to Enzymology
This session focuses on taking a look at enzymes from different angles to understand how they work, using a variety of techniques ranging from classical kinetic and labeling methods to computer simulations to imaging. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts.
7:30 pm - 7:45 pm
"Catching a Metabolon in Action: 3D Chemical Imaging of Single Cells by Secondary Ion Mass Spectrometry to Study Purinosomes"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Integrated Experimental-Computational Approaches Elucidate Dynamic Conformational Landscapes of SETD8"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Secondary 18 O Kinetic Isotope Effects as Evidence Against a Reverse Protonation Mechanism on Phosphite Dehydrogenase"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Allosteric Regulation of Pyruvate Carboxylase"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"From 'Structure–Function' to 'Ensemble–Function' Relationships: A Paradigm for Interpretation of Mutational Effects and Precision in Enzyme Active Sites"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Mechanism of Oxacyclization Catalyzed by Iron- and 2-Oxoglutarate Dependent Dioxygenase LolO in the Loline Alkaloid Biosynthesis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Enzymes and Metabolic Pathways: From Curiosity to Applications
This session focuses on application of knowledge learned from studying enzymes and metabolic pathways. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts.
9:00 am - 9:15 am
"Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni "
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Highjacking the Mechanism of GlgE for Tuberculosis Drug Discovery"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Exploring Ancestral Sequence Reconstruction as a Strategy for Enzyme Engineering"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Engineering of Modular Polyketide Synthases: Influence of Protein-Protein and Protein-Substrate Interactions"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Benchtop Synthesis of Thiopeptides"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Which Road to Take? Perspectives from Scientists in Different Careers
This session serves as a career development discussion panel of the meeting. The panelists include junior and veteran investigators in academia, industry, and science policy. The panelists will share their stories, offer advice on career development, and answer questions from meeting attendees.
1:30 pm - 2:30 pm
Panel Discussion
Perspectives from Scientists in Different Careers
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes