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Enzymes, Coenzymes and Metabolic Pathways (GRS)

Gordon Research Seminar

Enzymes and Metabolism: Linking Molecular Mechanisms to Biology, Medicine and the Environment

July 20 - 21, 2019
Chair
Waterville Valley
56 Packard's Road
Waterville Valley, New Hampshire, United States
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on Enzymes, Coenzymes and Metabolic Pathways is a forum for graduate students, post-docs, and other early career scientists to present their work and exchange ideas. The GRS provides its attendees with an informal environment for community-building and fosters long-lasting professional connections. GRS attendees are strongly encouraged to attend the associated GRC.

The 2019 GRS will feature oral and poster presentations in broad topic areas including biochemistry, enzymology, macromolecular structure, chemical biology, and metabolism. Interdisciplinary studies and and applications of enzyme research in health, industry, and the environment are encouraged. In addition to the scientific program, the GRS will feature a discussion panel with established and junior leaders from academia, industry, and beyond.

Related Meeting

This GRS will be held in conjunction with the "Enzymes, Coenzymes and Metabolic Pathways" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Enzymes and Metabolic Pathways in Sickness and in Health
Discussion Leader:
3:45 pm - 4:15 pm
"Lessons from 30 Years of Studying and Engineering Polyketide Biosynthesis"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Building Life's Complex Molecules
Discussion Leader:
7:30 pm - 7:45 pm
"Engineering Synthetic Metabolic Pathways for the Assimilation of Formate"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Substitution of an Aromatic Methyl Group with an Amine: A Flavoenzyme Converts a Vitamin into an Antibiotic"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Understanding the Alternative Activities of DXP Synthase"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"A Conserved and Universal Mechanism for Poly-Glutamylation of Biomolecules"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Beta-Keto Decarboxylation Unveiled: Sulfonate/Nitro Bearing Methylmalonyl-Thioester Isosteres Applied to Enzyme Structure-Function Studies"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Avant-Garde Assembly-Line Biosynthesis Expands Diversity of Cyclic Lipodepsipeptide Products"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Evolution of Enzyme Function, Specificity and Regulation
Discussion Leader:
9:00 am - 9:15 am
"Substrate-Differentiated Transition States of SET7/9-Catalyzed Lysine Methylation"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Elucidating the Evolution of Non-Receptor Tyrosine Kinase Specificity"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Unexpected Roles of Tethering in Modular Nitrite Reductase Catalysis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"A Simple Evolutionary Mechanism for Reciprocal Enzymatic Temperature Adaptation from Substitution of a Single Hydrogen Bond"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Unraveling the Selectivity Secrets of Flavin-Dependent Monooxygenases"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Closer to the Madding Crowd: Probing Enzyme Catalysis in Cell-Like Environs"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Finding a Path to a Rewarding Scientific Career
Panelists from a wide range of careers (academia, industry, policy and beyond) will share their stories, offer advice on career development, and answer questions from meeting attendees.
Discussion Leader:
1:30 pm - 2:30 pm
Panel Discussion
Perspectives from Scientists Across the Career Spectrum
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes

Contributors

American Association for the Advancement of Science (AAAS) - Science

University of Illinois at Urbana-Champaign - Institute for Genomic Biology

Zymergen

Montana State University - Office of Research and Economic Development

Marquette University
Incyte Corporation
DuPont Industrial Biosciences
Corteva Agriscience, the agricultural division of DowDuPont
AstraZeneca
American Chemical Society - Division of Biological Chemistry
University of Illinois at Urbana-Champaign
North Carolina GlaxoSmithKline Foundation

Conference Links

Conference History Enzymes, Coenzymes and Metabolic Pathways
Additional Fee Info

Enzymes, Coenzymes and Metabolic Pathways
July 20 - 25, 2025


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