Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Enzymes and Metabolic Pathways in Sickness and in Health
Discussion Leader: Miha Homšak (The Francis Crick Institute / Imperial College London, United Kingdom)
3:45 pm - 4:15 pm
Chaitan Khosla (Stanford University, USA)
"Lessons from 30 Years of Studying and Engineering Polyketide Biosynthesis"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Building Life's Complex Molecules
Discussion Leader: April Lukowski (University of Michigan, USA)
7:30 pm - 7:45 pm
Simon Burgener (Max Planck Institute for Terrestrial Microbiology, Germany)
"Engineering Synthetic Metabolic Pathways for the Assimilation of Formate"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Isita Jhulki (Texas A&M University, USA)
"Substitution of an Aromatic Methyl Group with an Amine: A Flavoenzyme Converts a Vitamin into an Antibiotic"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Melanie Johnston (Johns Hopkins University School of Medicine, USA)
"Understanding the Alternative Activities of DXP Synthase"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Ghader Bashiri (The University of Auckland, New Zealand)
"A Conserved and Universal Mechanism for Poly-Glutamylation of Biomolecules"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Lee Stunkard (Purdue University, USA)
"Beta-Keto Decarboxylation Unveiled: Sulfonate/Nitro Bearing Methylmalonyl-Thioester Isosteres Applied to Enzyme Structure-Function Studies"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jia Jia Zhang (University of California, San Diego, USA)
"Avant-Garde Assembly-Line Biosynthesis Expands Diversity of Cyclic Lipodepsipeptide Products"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Evolution of Enzyme Function, Specificity and Regulation
Discussion Leader: Callum Nicoll (University of Pavia, Italy)
9:00 am - 9:15 am
Shi Chen (Memorial Sloan Kettering Cancer Center, USA)
"Substrate-Differentiated Transition States of SET7/9-Catalyzed Lysine Methylation"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Patrick Finneran (Brandeis University, USA)
"Elucidating the Evolution of Non-Receptor Tyrosine Kinase Specificity"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Tobias Hedison (Manchester Institute of Biotechnology, United Kingdom)
"Unexpected Roles of Tethering in Modular Nitrite Reductase Catalysis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Margaux Pinney (Stanford University, USA)
"A Simple Evolutionary Mechanism for Reciprocal Enzymatic Temperature Adaptation from Substitution of a Single Hydrogen Bond"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Attabey Rodriguez Benitez (University of Michigan, Ann Arbor, USA)
"Unraveling the Selectivity Secrets of Flavin-Dependent Monooxygenases"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Natalia Yewdall (Institute for Complex Molecular Systems, Eindhoven University of Technology, The Netherlands)
"Closer to the Madding Crowd: Probing Enzyme Catalysis in Cell-Like Environs"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Finding a Path to a Rewarding Scientific Career
Panelists from a wide range of careers (academia, industry, policy and beyond) will share their stories, offer advice on career development, and answer questions from meeting attendees.
Discussion Leader: Melanie Johnston (Johns Hopkins University School of Medicine, USA)
1:30 pm - 2:30 pm
Panel Discussion
Perspectives from Scientists Across the Career Spectrum
Jennifer Bridwell-Rabb (University of Michigan, USA)
Benjamin Corb (American Society for Biochemistry and Molecular Biology, USA)
Chaitan Khosla (Stanford University, USA)
Robert Cicchillo (Corteva Agriscience™, USA)
Lesley-Ann Giddings (Middlebury College, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
