The Enzymology of Human Health, Biotechnology and the Environment

July 23 - 24, 2022

Chair

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar (GRS) on Enzymes, Coenzymes and Metabolic Pathways is a unique forum for graduate students, postdoctoral researchers, and other early career scientists to present their work and exchange ideas. The GRS provides its attendees with an informal environment for community-building and fosters long-lasting professional connections. The seminar helps set the tone and empower the attendees for success during the associated Gordon Research Conference, which our GRS attendees are strongly encouraged to attend.

The 2022 GRS will feature oral and poster presentations in broad topic areas including biochemistry, enzymology, macromolecular structure, chemical biology, and metabolism. Interdisciplinary studies and applications of enzyme research in health, industry, and the environment are encouraged. In addition to the scientific program, the GRS will feature a discussion panel with representatives from academia, industry, and policy to discuss career planning, mentoring, and other challenges of the field.

Related Meeting

This GRS will be held in conjunction with the "Enzymes, Coenzymes and Metabolic Pathways" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Structure, Function and Evolution of Protein Families Discussion Leader:
3:45 pm - 4:15 pm	"Beyond the Active Site: Structural Origins of Chemistry and Specificity in Membrane-Associated Glycan Assembly"
4:15 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Enzymology of Protein Folding, Function and Regulation Discussion Leader:
7:30 pm - 7:45 pm	"Microscopic Origins of Thermal Activation and Non-Linear Arrhenius Plots of Enzymes Using Multi-Temperature Crystallography"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"SFX-XFELs Reveals an Electron Hopping Mechanism for Cytochrome P450 CYP121"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Site-Specific, Bioorthogonal Protein Labeling Using Endogenous ß-Amino Acid Dienophiles Derived from Natural Product Biosynthesis"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"On the Evolutionary Origins of P-loop NTPases"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Multiple Modes of Inhibition from a Single Allosteric Site"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"A Long Range Recruitment Mechanism Drives mTORC2 Phosphorylation of Akt"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Discovery of Enzyme Chemistry and Metabolic Pathways Discussion Leader:
9:00 am - 9:15 am	"Deciphering the Reaction Pathway of Mononuclear Iron Enzyme Catalyzed N?C Triple Bond Formation"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Mechanistic Investigations on the Flavin-Dependent Sulfoxide C-S lyase CmoJ in a Cysteine Salvage Pathway"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Enzymatic Activation of Highly Stable Diazirines"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Functional and Structural Characterization of CtdP, a Highly Stereoselective Intramolecular Diels-Alderase"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"Design Principle for Site-Selective Hydroxylation in a Pair of Rieske Oxygenases"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"Parkinson's Disease Protein PARK7 Prevents Metabolite and Protein Damage Caused by a Glycolytic Metabolite"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Mentorship Component: The Opportunities After Your PhD Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion The Opportunities After Your PhD
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Funding for this conference was made possible [in part] by 1 R13 AI 154657 - 01 from the National Institute of Allergy and Infectious Diseases and National Center for Advancing Translational Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Enzymes, Coenzymes and Metabolic Pathways

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