Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Structure, Function and Evolution of Protein Families
Discussion Leader: Joanna Afokai Quaye (Georgia State University, United States)
3:45 pm - 4:15 pm
Karen Allen (Boston University, United States)
"Beyond the Active Site: Structural Origins of Chemistry and Specificity in Membrane-Associated Glycan Assembly"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzymology of Protein Folding, Function and Regulation
Discussion Leader: Chang Cui (Harvard University, United States)
7:30 pm - 7:45 pm
Matt McLeod (Cornell University, United States)
"Microscopic Origins of Thermal Activation and Non-Linear Arrhenius Plots of Enzymes Using Multi-Temperature Crystallography"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Romie Nguyen (The University of Texas at San Antonio, United States)
"SFX-XFELs Reveals an Electron Hopping Mechanism for Cytochrome P450 CYP121"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Daniel Richter (ETH Zurich, Switzerland)
"Site-Specific, Bioorthogonal Protein Labeling Using Endogenous ß-Amino Acid Dienophiles Derived from Natural Product Biosynthesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Pratik Vyas (Weizmann Institute of Science, Israel)
"On the Evolutionary Origins of P-loop NTPases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Jonathan Bailey (The Francis Crick Institute, United Kingdom)
"Multiple Modes of Inhibition from a Single Allosteric Site"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Maggie Chen (Harvard University, United States)
"A Long Range Recruitment Mechanism Drives mTORC2 Phosphorylation of Akt"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Discovery of Enzyme Chemistry and Metabolic Pathways
Discussion Leader: Samuel Eaton (University of Pennsylvania, United States)
9:00 am - 9:15 am
Tzu-Yu Chen (North Carolina State University, United States)
"Deciphering the Reaction Pathway of Mononuclear Iron Enzyme Catalyzed N?C Triple Bond Formation"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Sohan Hazra (Texas A&M University, United States)
"Mechanistic Investigations on the Flavin-Dependent Sulfoxide C-S lyase CmoJ in a Cysteine Salvage Pathway"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Nicholas Porter (California Institute of Technology, United States)
"Enzymatic Activation of Highly Stable Diazirines"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Sebastian Rivera (University of Michigan, United States)
"Functional and Structural Characterization of CtdP, a Highly Stereoselective Intramolecular Diels-Alderase"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Jiayi Tian (University of Michigan, United States)
"Design Principle for Site-Selective Hydroxylation in a Pair of Rieske Oxygenases"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Francesco Caligiore (Université catholique de Louvain (UCL), Belgium)
"Parkinson's Disease Protein PARK7 Prevents Metabolite and Protein Damage Caused by a Glycolytic Metabolite"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Mentorship Component: The Opportunities After Your PhD
Discussion Leader: Shamin Fernando (University at Buffalo, SUNY, United States)
1:30 pm - 2:30 pm
Panel Discussion
The Opportunities After Your PhD
Lynn Abell ( , United States)
Catherine Goodman (American Chemical Society, United States)
Pablo Sobrado (Virginia Tech, United States)
Karen Allen (Boston University, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
