| August 8, Sunday Evening, 7:30pm | Epigenetic Effects/Inheritance I
|
7:30 Welcome
7:45 Discussion Leader: Vicki Chandler
7:50 Vicki Chandler, University of Arizona
"Mutations affecting paramutation, allelic interaction that heritably alters transcription"
8:25 Bill Eggleston, Virginia Commonwealth University
"Requirements for paramutagenicity at the maize r locus"
9:00 Break
9:20 Eric Selker, University of Oregon
"Function and control of DNA methylation in Neurospora"
9.55 Cho-Ting Wu, Harvard University
"Transvection: A case of cooperation between alleles"
10:30 Session ends, social in snack bar
| August 9, Monday Morning, 8:30am | Epigenetic Effects/Inheritance II |
8:30 Photo
9:00 Discussion Leader: Amar Klar
9:05 Amar Klar, NCI-Frederick Cancer Research and Development Center
"A novel mechanism of imprinting for mat1 switching in s. pombe"
9:40 Judith Bender, Johns Hopkins University
"Methylation and silencing of the PAI genes in Arabidopsis"
10:00 Suzy Cocciolone, Iowa State University
"Epigenetic regulation of expression of the P locus of maize"
10:35 Break
11:00 Azim Surani, Cambridge, UK
"An analysis of a silencer-imprinting cis control element in Drosophila and in mice"
11:35 Laura Carrel, Case Western Reserve University
"X-chromosome inactivation"
12:10 Emma Whitelaw, University of Sydney
"Epigenetic inheritance at the agouti locus in the mouse"
12:30 Lunch
Poster Session 4:00-6:00 Odd-numbered posters
| August 9, Monday Evening, 7:30pm | Epigenetics in Fungi |
7:30 Discussion Leader: James R. Broach
7:35 James R. Broach, Princeton University
"Mating type silencing and switching in Saccharomyces"
8:10 David Rivier, University of Illinois, Urbana-Champaign
"Locus-specific regulators of position-effect silencing in S. cerevisiae"
8:45 Break
9:05 Kristin Scott, Edinburgh University
"Centromere and telomere structure and function in fission yeast"
9:40 Jean-Luc Rossignol, Institute Jacques Monod
"DNA methylation, chromatin and gene silencing in Ascobolus"
10:15 Session ends
| August 10, Tuesday Morning, 9:00am | Imprinting |
9:00 Discussion Leader: Shirley Tilghman
9:05 Shirley Tilghman, Princeton University
"Mechanism of genomic imprinting"
9:40 Denise Barlow, Netherlands Cancer Institute, Amsterdam
"Competition: A common mechanism for gene imprinting"
10:15 Wolf Reik, Babraham Hall, Cambridge
"New imprinting mutations in the distal chromosome 7 imprinting cluster in the mouse"
10:50 Break
11:05 Colum Walsh, University of Ulster
"Methylation and acetylation are uncoupled at three imprinted genes"
11:25 Abou Elkharroubi, ABL-NCI, Frederick
"Role of histone deacetylase and DNA methylation in the regulation of imprinted genes in androgenetic and parthogenetic mouse fibroblasts"
11:45 Mary Alleman, Duquesne University
"Imprinting of the R gene in Maize"
12:30 Lunch
| August 10, Tuesday Evening, 7:30pm | Methylation and Epigenetics |
7:30 Discussion Leader: Tim Bestor
7:35 Tim Bestor, Columbia University
"Cytosine methylation and promoter silencing in mammals"
8:10 Rudi Jaenisch, MIT, Cambridge
"DNA methylation, development and cancer"
8:45 Masaki Okano, MGH, Harvard Medical School
"De novo DNA cytosine-5 methyltransferases in mouse embryonic stem cells"
9:05 Break
9:25 Jean Finnegan, CSIRO, Australia
"The role of DNA methylation in vernalization - the promotion of flowering in response to low temperatures"
10:00 Luca Comai, University of Washington
"DNA methylation and epigenetic interactions in Arabidopsis hybrids"
10:35 Session ends
| August 11, Wednesday Morning, 9:00 | Chromatin and Epigenetics
|
9:00 Discussion Leader: Alan Wolffe
9:05 Alan Wolffe, NCI, Bethesda
"The DNA methylation-chromatin connection"
9:40 Adrian Bird, University of Edinburgh
"Functional studies of methyl-CpG binding proteins"
10:15 Mike Grunstein, UCLA
"Repression mechanisms through histone deacetylation in yeast."
10:50 Break
11:15 Vincenzo Pirrotta, University of Geneva
"Polycomb complexes and silencing mechanisms"
11:50 Eric Richards, Washington University
"DNA methylation and epigenetic inheritance"
12:30 Lunch
Poster Session 4:00-6:00 Even-numbered posters
| August 11, Wednesday Evening, 7:30pm | Mechanisms I |
7:30 Discussion Leader: Marjori Matzke
7:35 Marjori Matzke, Institute of Molecular Biology, Austria
"Transgene silencing and methylation: DNA-DNA or RNA-DNA interaction?"
8:10 Ortrun Mittelsten Scheid, Friedrich Institute, Switzerland
"Transcriptional gene silencing in plants: tracing tools and targets"
8:45 Heriberto Cerutti, University of Nebraska
"Epigenetic silencing of nuclear transgenes in Chlamydomonas"
9:05 Break
9:25 David Finnegan, University of Edinburgh
"Epigenetic control of the I factor, a retrotransposon in Drosophila"
10:00 Shiv Grewal, Cold Spring Harbor Laboratory
"Mechanism of epigenetic inheritance in fission yeast"
10:35 Session ends
| August 12, Thursday Morning, 9:00am | Mechanisms II |
9:00 Discussion Leader: Steve Henikoff
9.05 Steve Henikoff, Fred Hutchinson Cancer Center, Seattle
"Heterochromatin during the cell cycle in Drosophila"
9:40 Bruce Stillman, Cold Spring Harbor Laboratory
"DNA replication duplicates chromatin assembly and epigenetic inheritance"
10:15 Phillip Yates, Oregon Health Science University
"Evidence that transcriptional inactivation preceded DNA methylation in the methylation-associated inactivation of the mouse Aprt promoter
10:35 Break
11:00 Jeff Chen, Washington University, St Louis
"Uniparental rRNA gene silencing (nucleolar dominance) in Arabidopsis and Brassica"
11.20 Rich Jorgensen, University of Arizona
"Epigenetic changes in patterns of cosuppression of flower color genes"
11.55 Christophe Beclin, INRA, France
"Genes involved in the control of post-transcriptional gene silencing"
12.30 Lunch
Social and Poster Session 4:00-6:00
| August 12, Thursday Evening, 7.30pm | Mechanisms III |
7:30 Business Meeting
7.45 Discussion Leader: Jean Finnegan
7.50 Peter Waterhouse, CSIRO, Australia
"Virus resistance and gene silencing can be induced by simultaneous expression of sense and antisense RNA"
8.25 Andrew Fire, Johns Hopkins University
"Double stranded RNA-mediated genetic interference in C. elegans"
9:00 Break
9.25 Titia Sijen, Free University, Amsterdam
"Does an RNA-dependent RNA polymerase have a role in post-transcriptional gene-silencing"
9:55 Robert Martienssen, Cold Spring Harbor Laboratory
"Epigenetics and plant genome"
10:30 Session ends
| August 14, Friday Morning |
Depart Holderness
| 