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Epigenetics

Gordon Research Conference

August 5 - 10, 2007
Chairs Anne C. Ferguson-Smith and Steve E. Jacobsen
Vice Chairs Jeannie T. Lee and Ueli Grossniklaus
Holderness School
33 Chapel Lane
Holderness, New Hampshire, United States
 Venue and Travel Information

Conference Description

Epigenetics describes the study of heritable changes in genome function that occur without a change in the DNA sequence. Genome function and integrity depends on epigenetic factors including modifications to DNA and chromatin that bring functional conformation to chromosomes. For this 7th Gordon Conference on Epigenetics, key themes have been selected that explore the molecular players contributing to the epigenetic control of genome function using a wide range of model organisms and allowing specific and common principles and mechanisms to be considered.

Conference Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmEPIGENOMICS
Discussion Leader: Steve Jacobsen (HHMI, UCLA)
7:35 pm - 7:55 pm Brad Bernstein (Broad Institute, USA)
"Chromatin state maps of pluripotent and lineage committed cells"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Bing Ren (Ludwig Institute, UCSD)
"Genome annotation using a conserved genetic code"
8:20 pm - 8:25 pm Discussion
8:25 pm - 8:45 pm Peter Jones (USC/Norris Comprehensive Cancer Center)
"The cancer epigenome"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:00 pm Short Talk: Suhua Feng (HHMI - UCLA)
"Epigenetic profiling in Arabidopsis"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Vincenzo Pirrotta (Rutgers University)
"Alternative chromatin states of Polycomb target genes"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amGroup Photo
9:00 am - 12:30 pmDNA METHYLATION
Discussion Leader: John Greally (Albert Einstein College of Medicine)
9:00 am - 9:20 am Eric Selker (University of Oregon)
"Advances in understanding the control of DNA methylation in Neurospora"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Judith Bender (Johns Hopkins University)
"A histone-dependent DNA methylation pathway"
9:45 am - 9:50 am Discussion
9:50 am - 10:10 am Hiro Sasaki (NIGR, Mishima, Japan)
"Genome imprinting mechanisms in the mouse germline and early embryos"
10:10 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 10:55 am Short Talk: Fred Berger (Temasek Life Science Laboratory, Singapore)
"Epigenetic control of resource allocation to the Arabidopsis embryo involves DNA methylation and trans-silencing"
10:55 am - 11:00 am Discussion
11:00 am - 11:20 am Tim Bestor (Columbia University)
"Interactions of histone methylation and DNA CpG methylation"
11:20 am - 11:25 am Discussion
11:25 am - 11:45 am Xiaodong Cheng (Emory University)
"Structure of mammalian Dnmt3a-Dnmt3L complex"
11:45 am - 11:50 am Discussion
11:50 am - 12:10 pm Taiping Chen (Novartis)
"Lsd1 mutation leads to embryonic lethality and genome-wide hypomethylation"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Hidetoshi Saze (National Institute of Genetics, Japan)
"Genetic dissection of DNA methylation at the BONSAI locus"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHISTONE MODIFICATIONS AND VARIANTS
Discussion Leader: Sarah Elgin (Washington University, St Louis)
7:30 pm - 7:50 pm Karolin Luger (Colorado State University)
"Nucleosomes and their chaperones"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:15 pm Steve Henikoff (Fred Hutchinson Cancer Research Center)
"Histone variant dynamics and epigenetics"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Justin Goodrich (University of Edinburgh)
"Whole genome screens for novel Polycomb group gene targets"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Terry Magnuson (UNC - Chapel Hill)
"Epigenetic mechanisms of X inactivation"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Short Talk: Juan Casas-Mollano (University of Nebraska, Lincoln)
"Histone H3 Threonine 3 Phosphorylation (H3T3ph) as an inheritable mark for silenced euchromatin in Chlamydomonas"
9:20 pm - 9:25 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIMPRINTING, DOSAGE COMPENSATION & CHROMOSOMAL MECHANISMS
Discussion Leader: Emma Whitelaw (Queensland Institute of Medical Research)
9:00 am - 9:20 am Ueli Grossniklaus (University of Zurich)
"Regulation of genomic imprinting in Arabidopsis"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Marisa Bartolomei (University of Pennsylvania)
"Mechanism of genomic imprinting at the H19/Igf2 locus"
9:45 am - 9:50 am Discussion
9:50 am - 10:10 am Jeannie Lee (Massachussetts General Hospital, Harvard University)
"X inactivation: sex, heterochromatin, pairing and more"
10:10 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 am Barbara Meyer (HHMI - UC Berkeley)
"Regulation of X chromosome-wide repression and recombination"
11:05 am - 11:10 am Discussion
11:10 am - 11:30 am Jim Birchler (University of Missouri)
"Studies on the function of the male specific lethal (MSL) complex in Drosophila"
11:30 am - 11:35 am Discussion
11:35 am - 11:55 am Asifa Akhtar (EMBO labs, Heidelberg)
"Dosage compensation in Drosophila: MSLs and beyond"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Ting Wu (Harvard University)
"Ultra-conserved elements - sentinels of genome integrity?"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmROLES OF RNA I
Discussion Leader: Anne Ferguson-Smith (University of Cambridge)
7:30 pm - 7.50 pm Philip Zamore (University of Massachusetts Medical School, Worcester)
"Small silencing RNA pathways"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:15 pm Rob Martienssen (Cold Spring Harbor Laboratories)
"Silent running: heterochromatin and RNAi in plants and fission yeast"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Olivier Voinnet (CNRS Strasbourg)
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Craig Pikaard
"Roles of RNA polymerase IV and nuclear siRNAs in heterochromatin organization and gene regulation"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Short Talk: Elissa Lei (NIDDK, NIH)
"Identification of noncoding RNAs associated with the gypsy chromatin insulator"
9:20 pm - 9:25 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:45 amROLES OF RNA II
Discussion Leader: Bill Kelly (Emory University)
9:00 am - 9:20 am Denise Barlow (CEMM - Research Center for Molecular Medicine, Austria)
"Gene silencing in imprinted gene clusters by long ncRNAs"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Marjori Matzke (Gregor Mendel Institute, Austria)
"Genetic analysis of RNA-directed DNA methylation"
9:45 am - 9:50 am Discussion
9:50 am - 10:10 am Vicki Chandler (BIO5 Institute, University of Arizona)
"Paramutation: RNA mediated meiotically-heritable silencing"
10:10 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 12:30 pmREGULATION OF CHROMATIN
10:45 am - 11:05 am Shiv Grewal (NCI - NIH)
"Heterochromatin: a versatile platform of the genome"
11:05 am - 11:10 am Discussion
11:10 am - 11:20 am Short Talk: Sriharsa Pradhan (New England Biolabs, Mass)
"G9a automethylation imply wider substrate specificity and HP1 binding"
11:20 am - 11:25 am Discussion
11:25 am - 11:35 am Short Talk: Gerhard Rank (Royal Melbourne Hospital, Australia)
"The protein methyltransferase PRMT5 links histone H4 methylation to Dnmt3a-dependent DNA methylation and transcriptional silencing"
11:35 am - 11:40 am Discussion
11:40 am - 12:00 pm Hiten Madhani (UCSF)
"Determinants of promoter chromatin architecture in S. cerevisiae"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:25 pm David Spector (Cold Spring Harbor Laboratory)
"Nuclear organization and gene silencing"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEPIGENETICS IN DEVELOPMENT
Discussion Leader: John McCarrey (University of Texas, San Antonio)
7:30 pm - 7:50 pm Petra Hajkova (Gurdon Institute, University of Cambridge)
"Epigenetic reprogramming of the early mouse germ cell lineage"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:05 pm Short Talk: David Katz (Emory University, Georgia)
"H3K4me2 Demethylase Activity Guards the Immortality of the Germline by Preventing Epigenetic Inheritance"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:30 pm Wolf Reik (Babraham Institute, Cambridge)
"Regulation of imprinting and epigenetic programming in mammalian development"
8:30 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Renato Paro (ETH Zurich, Switzerland)
"The epigenetic control of tissue regeneration in Drosophila"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Rudolph Jaenisch (Whitehead Institute, MIT)
"Stem cells, pluripotency and epigenetic programming"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences)
9:00 am - 12:30 pmDISEASE, ENVIRONMENT, EVOLUTION
Discussion Leader: Amar Klar (NCI, Frederick)
9:00 am - 9:20 am Steve Baylin (Johns Hopkins University)
"The cancer epigenome and its role in tumor initiation and progression"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Mike Higgins (Roswell Park Cancer Institute)
"Imprinted expression of Cdkn1c, overgrowth and Beckwith Wiedemann Syndrome"
9:45 am - 9:50 am Discussion
9:50 am - 10:00 am Short Talk: Art Petronis (CAMH, University of Toronto)
"Epigenomic studies of major psychosis"
10:00 am - 10:05 am Discussion
10:05 am Coffee Break
Discussion Leader: Jean Finnegan (CSIRO, Canberra)
10:35 am - 10:55 am Phil Avner (Pasteur Institute, France)
"Plasticity and evolution in the X inactivation process"
10:55 am - 11:00 am Discussion
11:00 am - 11:20 am Rick Amasino (University of Wisconsin)
"Vernalization: remembering winter with an epigenetic switch"
11:20 am - 11:25 am Discussion
11:25 am - 11:45 am Eric Richards (Washington University, St Louis)
"Mining natural epigenetic variation"
11:45 am - 11:50 am Discussion
11:50 am - 12:00 pm Short Talk: Vincent Colot (INRA-CNRS, France)
"Transgenerational inheritance patterns of DNA methylation in Arabidopsis"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:15 pm Short Talk: Catherine Suter (Victor Chang Cardiac Research Institute, Sydney)
"Germline epimutations in human"
12:15 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDYNAMIC NUCLEUS
Discussion Leader: Jasper Rine (UC - Berkeley)
7:30 pm - 7:40 pm Short Talk: Pedro Crevillen (John Innes Centre, Norwich)
"Epigenetic regulation of flowering time"
7:40 pm - 7:45 pm Discussion
7:45 pm - 8:05 pm Peter Fraser (Babraham Institute, Cambridge)
"3-D transcriptional networks"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:30 pm Edith Heard (Institut Curie, France)
"The nuclear choreography underlying initiation of X inactivation"
8:30 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Stephane Ronsseray (Institut Jacques Monod, Paris)
"P element repression in Drosophila by epigenetic telomeric trans-silencing involving heterochromatin formation and the rasiRNA silencing pathway"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Short Talk: Sylvia Erhardt (UC Berkeley and LBNL)
"Epigenetic regulation of centromeres"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:30 pm Meeting Closure
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Contributors

Conference Links

Conference History
Additional Fee Info

Cancer Genetics and Epigenetics
May 18 - 23, 2025
Centromere Biology
July 28 - August 2, 2024
Chromatin Structure and Function
July 7 - 12, 2024
Chromosome Dynamics
June 22 - 27, 2025
Epigenetics (GRS)
August 9 - 10, 2025
Histone and DNA Modifications
July 20 - 25, 2025


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