SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 7:40 pm | Welcome Note by the Organizers |
7:40 pm - 9:30 pm | CLASSIC EPIGENETIC PHENOMENA |
| Discussion Leader: Eric Richards (Cornell University) |
7:40 pm - 7:55 pm | Vicky Chandler (University of Arizona)
"Epigenetic Silencing across Generations" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:15 pm | Paul Soloway (Cornell University)
"Successful Computational Prediction of Novel Imprinted Genes from Epigenomic Features" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Ting Wu (Harvard Medical School)
"Implications of homology" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Steve Henikoff (Fred Hutchinson Cancer Research Center)
"Epigenetic Inheritance of Centromeric Chromatin" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Short Talk: Doug Chalker (Washington University, St. Louis)
"Dynamic nuclear reorganization and extensive genome rearrangements remodel the differentiating somatic nucleus of Tetrahymena" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | Eric Richards: Synthesis & Discussion - What is epigenetics? |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:45 am | Group Photo |
9:00 am - 12:30 pm | GERMLINE & TRANSGENERATIONAL INHERITANCE |
| Discussion Leader: William Kelley (Emory University, GA) |
9:00 am - 9:15 am | Brad Cairns (University of Utah)
"Chromatin Packaging in Mature Germ Cells" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Marcus Pembrey (University of Bristol, UK)
"Male-line Transgenerational Responses in Humans" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Hiroyuki Sasaki (National Institute of Genetics, Shizuoka, Japan)
"Genomic Imprinting, DNA Methylation and Small RNAs in Mammalian Germ Cells" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Short Talk: Yoav Soen (Weizmann Institute, Israel)
"Trans-generational Inheritance of Plastic Responses to a Novel Challenge Presented to Developing Flies" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Pat Shiu (University of Missouri)
"Meiotic Silencing by Unpaired DNA" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:20 am | James Turner (National Institute for Medical Research, UK)
"Meiotic Silencing in Mammals" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Short Talk: Frederic Chedin (UC-Davis)
"Formation of long, stable R-loops is a novel characteristic of the human SNRPN and mouse Air imprinting centers" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Short Talk: Jonathan Schneiderman (Harvard Medical School)
"Transcriptional and germline functions for the H3.3 histone variant" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Short Talk: Felipe Texeira (CNRS, France)
"Widespread gene misregulation due to loss of DNA methylation over repeat elements in Arabidopsis" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | William Kelley: Synthesis & Discussion - How much and how far can the germline transmit? |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | EPIGENETIC REPROGRAMMING DURING DEVELOPMENT |
| Discussion Leader: Robert Feil (CNRS, France) |
7:30 pm - 7:45 pm | Rudolf Jaenisch (Whitehead Institute for Biomedical Research)
"The Epigenetic (In)stability of the Pluripotent and Differentiated Cell State" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Wolf Reik (The Babraham Institute, UK)
"Regulation of Epigenetic Reprogramming in Mammalian Development" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Daniel Grimanelli (Institut de Recherche et Dévelopment, France)
"Chromatin-Level Control of Reproductive Strategies in Plants" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Anne Ferguson-Smith (University of Cambridge, UK)
"Imprinted Genes and Mammalian Development" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 am | Short Talk: Frederic Berger (National University of Singapore)
"Epigenetic Reprogramming of Histone Marks during Sexual Reproduction in Arabidopsis" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Robert Feil: Synthesis & Discussion - Challenges during reprogramming |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BALANCING THE EPIGENOME |
| Discussion Leader: Marisa Bartolomei (University of Pennsylvania) |
9:00 am - 9:15 am | Jenny Graves (Australian National University, Australia)
"The Chromosomal Balancing Act in Marsupials and Monotremes" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Peter Becker (Munich University, Germany)
"Regulation of the Male X in Drosophila by the MSL complex" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Jim Birchler (University of Missouri)
Genomic Balance and the Male Specific Lethal (MSL) Complex in Drosophila" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Short Talk: Christine Disteche (University of Washington, Seattle)
"Complex Genome-Wide Balancing Acts in Eutherian Mammals" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Barbara Meyer (University of California-Berkeley)
"Dosage Compensation in Round Worms and its Connection to Meiosis" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:20 am | Jeffrey Chen (University of Texas)
"An Epigenetic Balance around the Clock: a Molecular Basis for Growth Vigor in Hybrids and Allopolyploids" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Peter Fraser (The Babraham Institute, UK)
"The transcriptional interactome; overlapping networks of gene co-associations at transcription factories" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Short Talk: Laura Carrel (Penn State University)
"A conserved hypomethylated multi-gene domain on the inactive X chromosome" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Marisa Bartolomei: Synthesis & Discussion - Are there multiple methods of balancing the genome? Inverse effect versus dosage compensation |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | EPIGENETICS IN HEALTH & DISEASE |
| Discussion Leader: Howard Cedar (Hebrew University, Israel) |
7:30 pm - 7:45 pm | Amar Klar (National Cancer Institute at Frederick)
"Cellular Differentiation through Epigenetics and Selective Chromatid Segregation" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Steve Baylin (Johns Hopkins University School of Medicine)
"Epigenetic Misregulation in Cancer" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Renato Paro (ETH Zürich, Switzerland)
"Epigenetic Control of Regeneration" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Rosanna Weksberg (SickKids, Canada)
"Epigenetics and Human Disease" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Jasper Rine (University of California-Berkeley)
"Effect of folate on gene activity in humans and yeast" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | Howard Cedar: Synthesis & Discussion - How much of disease is epigenetic versus genetic? |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ENVIRONMENTAL EPIGENETICS AND BEHAVIOR |
| Discussion Leader: Doug Ruden (Wayne State University) |
9:00 am - 9:15 am | Patricia Hunt (Washington State University)
"Epigenetic change effected by environmental toxins" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Emma Whitelaw (Queensland Institute of Medical Research, Australia)
"The Molecular basis of Intangible Variation" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Ortrun Mittelsten Scheid (Gregor Mendel Institute, Austria)
"Heat stress causes transient suppression of transcriptional gene silencing" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Short Talk: Bas Rutjens (John Innes Centre, UK)
"Cold-induced epigenetic silencing mediated by long non-coding FLC transcripts" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Moshe Szyf (McGill University, Canada)
"The impact of the early social environment on the adult epigenome" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:20 am | Catherine Dulac (Harvard University)
"Spatial, Temporal, Sex- and Species-Specific Genomic Imprinting in the Mouse Brain" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Susan Lindquist (Whitehead Institute for Biomedical Research, MIT)
"Prion proteins provide a survival strategy for generating heritable phenotypic diversity" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Reed Wickner (National Institutes of Health)
"The structural basis of protein-based inheritance" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Doug Ruden: Synthesis & Discussion - Lamarckian genetics via environmental influences and prions? |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | CHROMATIN MODIFIERS & DNA METHYLATION |
| Discussion Leader: Jean Finnegan (CSIRO, Australia) |
7:30 pm - 7:45 pm | Judith Bender (Brown University)
"The role of small RNAs in maintaining DNA methylation on duplicated sequences" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Eric Selker (University of Oregon)
"Control of DNA Methylation in Neurospora" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Steve Jacobsen (University of California-Los Angeles)
"Regulation of DNA Methylation and Histone Modifications in Arabidposis" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Marjori Matzke (Gregor Mendel Institute, Austria)
"RNA-directed DNA Methylation in Arabidopsis" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:10 pm | Andreas Houben (Leibniz Institute of Plant Genetics and Crop Research, Germany)
"Phosphorylation of Histone H3 in Plants - a Dynamic Affair" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | Jean Finnegan: Synthesis & Discussion - The connection between DNA & histone methylation in affecting genome behavior |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CONTROL BY TRANSPOSONS & ncRNA |
| Discussion Leader: Sarah Elgin (Washington University) |
9:00 am - 9:15 am | Tetsuji Kakutani (National Institute of Genetics, Shizuoka, Japan)
"Genetics of DNA Methylation in Genes and Transposons in Arabidopsis" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Jim Goodrich (University of Colorado)
"Regulation of Mammalian mRNA transcription by SINE RNAs" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Short Talk: Alysson Muotri (University of California-San Diego)
"L1 retrotransposition in the Nervous System" |
9:50 am - 9:55 am | Discussion |
9:55 am - 10:10 am | Denise Barlow (University of Vienna, Austria)
"Long ncRNA and Imprinting in Mammals" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Shiv Grewal (National Institutes of Health)
"RNAi-mediated Epigenetic Control of the Genome" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:20 am | Danesh Moazed (Harvard Medical School)
"Noncoding RNAs and Inheritance of Heterochromatin" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Rob Martienssen (Cold Spring Harbor Laboratories)
"Copying and Reprogramming Heterochromatin with RNA interference" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Tim Bestor (Columbia University)
"Regulation and Mechanism of de novo DNA methylation" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Sally Elgin: Synthesis & Discussion - Is junk DNA no longer junk? |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NUCLEAR ORGANIZATION |
| Discussion Leader: Thomas Cremer (Munich University, Germany) |
7:30 pm - 7:45 pm | Vince Pirrotta (Rutgers University, NJ)
"The role of Polycomb proteins in genome organization" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:00 pm | Short Talk: Pam Geyer (University of Iowa)
"Stem cell homeostasis in the Drosophila female gonad requires integrity of the nuclear lamina" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:20 pm | Alexandre Reymond (University of Lausanne, Switzerland)
"Genome structure and gene expression" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:40 pm | Wendy Bickmore (The Babraham Institute, UK)
"The repression of gene expression in the nuclear space" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Craig Pikaard (Washington University)
"Functions of nuclear RNA Polymerases IV and V in plant siRNA-directed gene silencing" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Thomas Cremer: Synthesis & Discussion - Nuclear organization as an epigenetic mechanism |
9:30 pm | Party |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |