Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Emerging Technologies and Advances in Epigenetics
Discussion Leader: Ortrun Mittelsten Scheid (Gregor Mendel Institute of Molecular Plant Biology, Austria)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Charles Gersbach (Duke University, USA)
"Epigenome Editing for Functional Epigenomics and Cell Programming"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Catherine Musselman (University of Iowa, USA)
"The Effect of Nucleosome Conformation on Histone Tail Binding: Implications in Chromatin Signaling"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Nathan Springer (University of Minnesota, USA)
"Life on the Edge: Gene-TE Interactions in Complex Genomes"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ting Wu (Harvard Medical School, USA)
"An Update on Imaging the Genome"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chromatin Modifications in Development
Discussion Leader: Sylvia Erhardt (ZMBH, Universität Heidelberg, Germany)
9:00 am - 9:35 am
Susan Gasser (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Roles of Nuclear Organization in Differentiated Cells"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Juerg Mueller (Max Planck Institute of Biochemistry, Germany)
"Molecular Mechanisms of the Polycomb/Trithorax System for Maintaining Transcriptional OFF and ON States"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
Edith Heard (Institut Curie, France)
"Transcriptional, Epigenetic and Chromosome Dynamics During X Inactivation"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:35 am
Xin Chen (Johns Hopkins University, USA)
"Breaking Symmetry – Asymmetric Epigenetic Inheritance During Drosophila Germline Stem Cell Asymmetric Division"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Bing Zhu (Institute of Biophysics, Chinese Academy of Sciences, China)
"Identification and Characterization of the Ash1 Complex and Its Function in Antagonizing Polycomb Silencing"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Susan Strome (University of California, Santa Cruz, USA) and Maria-Elena Torres-Padilla (Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Germany)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic RNAs
Discussion Leader: Juerg Mueller (Max Planck Institute of Biochemistry, Germany)
7:30 pm - 7:50 pm
Eric Miska (University of Cambridge, United Kingdom)
"Epigenetics and Phenotypic Variation: New Insights from Nematodes and Fishes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
John Rinn (Harvard University, USA)
"Chromatin Environment, Transcriptional Regulation, and Splicing Distinguish lincRNAs and mRNAs"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sylvia Erhardt (ZMBH, Universität Heidelberg, Germany)
"Centromeric tRNA Methylation Is Required for Chromosome Segregation in Mitosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Shiv Grewal (National Cancer Institute, NIH, USA)
"Epigenetic Genome Control by Conserved RNA Processing Factors"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Inheritance Between Generations
Discussion Leader: Harmit Malik (Fred Hutchinson Cancer Research Center, USA)
9:00 am - 9:20 am
Vincent Colot (Institut de Biologie de l'Ecole Normale Superieure, France)
"Transposable Elements, Transgenerational Epigenetics and Heritable Phenotypic Variation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Caroline Dean (John Innes Centre, United Kingdom)
"Vernalization: A Cold-Induced Epigenetic Switch"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Anne Ferguson-Smith (University of Cambridge, United Kingdom)
"Retrotransposons and the Heritability of Variable Epigenetic States"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Susan Strome (University of California, Santa Cruz, USA)
"Sperm Chromatin and Paternal Contributions to Epigenetic Inheritance in C. elegans "
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Satoshi Namekawa (Cincinnati Children's Hospital Medical Center, USA)
"Polycomb Directs Timely Activation of Germline Genes in Spermatogenesis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Richard Festenstein (Imperial College London, United Kingdom)
"Sex Differences and HP1"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Mary Goll (Memorial Sloan Kettering Cancer Center, USA)
"Heterochromatin Dynamics in the Early Zebrafish Embryo"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Environmental Impact on Epigenetics
Discussion Leader: Steven Jacobsen (University of California, Los Angeles / Howard Hughes Medical Institute, USA)
7:30 pm - 7:50 pm
Folami Ideraabdullah (University of North Carolina at Chapel Hill, USA)
"Impact of Maternal Vitamin D Status on the Male Germline Epigenome, Implications for Transmission"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Vardhman Rakyan (Blizard Institute, Queen Mary University of London, United Kingdom)
"Inter-Individual Epigenetic Variation and the Developmental Origins of Mammalian Phenotypes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sarah Hall (Syracuse University, USA)
"RNAi and Endocrine Signaling Program Adult Phenotypic Plasticity in C. elegans "
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Zachary Harvey (Stanford University, USA)
"Prion Switches Fuel the Inheritance of Chromatin States"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics and Disease
Discussion Leader: Anne Ferguson-Smith (University of Cambridge, United Kingdom)
9:00 am - 9:35 am
Wendy Bickmore (MRC Human Genetics Unit, University of Edinburgh, United Kingdom)
"Developmental Genome Regulation and Chromatin Folding"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Bradley Bernstein (Harvard University / Massachusetts General Hospital , USA)
"Epigenetic Plasticity in Tumor Initiation and Evolution"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
John Denu (University of Wisconsin-Madison, USA)
"Metabolic Control of the Epigenome"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:35 am
John Greally (Albert Einstein College of Medicine, USA)
"The Second-Generation Epigenome-Wide Association Study"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Mellissa Mann (Magee-Womens Research Institute, University of Pittsburgh, USA)
"Nucleoporin-Mediated Regulation of the Kcnq1ot1 Imprinted Domain in Embryonic and Extraembryonic Stem Cells"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Reprogramming
Discussion Leader: William Kelly (Emory University, USA)
7:30 pm - 7:50 pm
Mary Gehring (Whitehead Institute, USA)
"Dosage Control in Arabidopsis by Small RNAs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Robert Martienssen (Cold Spring Harbor Laboratory, USA)
"Epigenetic Inheritance and Reprogramming with Small RNA"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jamie Hackett (European Molecular Biology Laboratory, Italy)
"Deconvolving Germline Specification and Reprogramming"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Maria-Elena Torres-Padilla (Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Germany)
"Epigenetic Mechanisms in Early Mammalian Development"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Epigenetic Landscape Across Cell Division
Discussion Leader: Xin Chen (Johns Hopkins University, USA)
9:00 am - 9:20 am
Johnathan Whetstine (Harvard Medical School / Massachusetts General Hospital, USA)
"Epigenetic Mechanisms Regulate Cell Cycle and Drug Resistant Gene DNA Amplification"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Keith Maggert (University of Arizona, USA)
"Assessing the Timing and Stability of Epigenetic Silencing"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Steven Jacobsen (University of California, Los Angeles / Howard Hughes Medical Institute, USA)
"Mechanisms of DNA Methylation Control in Arabidopsis "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
David Gilbert (Florida State University, USA)
"Epigenetic vs. Sequence-Dependent Control of Replication Timing"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
R. Keith Slotkin (The Ohio State University, USA)
"Initiation of Transposable Element Trans-Generational Silencing"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Humaira Gowher (Purdue University, USA)
"Biological Outcome of the Catalytic Specialization of DNA Methyltransferases"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Timothy Bestor (College of Physicians and Surgeons, Columbia University, USA)
"De Novo Methylation by DNMT1"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetics Across Evolution
Discussion Leader: Ting Wu (Harvard Medical School, USA)
7:30 pm - 7:50 pm
Ozren Bogdanovic (Garvan Institute of Medical Research, Australia)
"Transphyletic Conservation of Developmental Epigenome Dynamics"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Harmit Malik (Fred Hutchinson Cancer Research Center, USA)
"Genetic Conflict at Animal Centromeres"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ines Drinnenberg (Institut Curie, France)
"Overcoming abCENPs: Recurrent Loss of CenH3 in Holocentric Insects"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Benjamin Loppin (Laboratoire de Biométrie et Biologie Évolutive, University of Lyon, France)
"Evolution of Sperm Nuclear Organization: Insights from Drosophila "
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure