Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Nuclear Organization
Discussion Leader: Pamela Geyer (University of Iowa, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Wendy Bickmore (MRC Human Genetics Unit, United Kingdom)
"3D Folding and Enhancer Function"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Leonid Mirny (Massachusetts Institute of Technology, USA)
"Two Mechanisms of Nuclear Organization"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Benjamin Sabari (Whitehead Institute for Biomedical Research, USA)
"A Condensate Model for Gene Activity and Genome Organization"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Alexandros Pertsinidis (Memorial Sloan Kettering Cancer Center, USA)
"Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription, Epigenetic Regulation and Genome Organization at Single Genes in Live Cells"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transposable Elements and Epigenome Evolution
Discussion Leader: Julie Ahringer (University of Cambridge, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Susan Gasser (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Avoiding Replication and Transcriptional Collisions by Repressing Repeats and Forming Nuclear Foci"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Didier Trono (Ecole Polytechnique Federale de Lausanne, Switzerland)
"How TEs and Their Krab-ZFP Controllers Shape Human-Specific Transcription Networks"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Aditi Shukla (Harvard Medical School, USA)
"pUG-Tailed RNAs Drive Gene Silencing and Transgenerational Epigenetic Inheritance"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Jennifer Frost (Queen Mary University of London, United Kingdom)
"Functional Evaluation of Transposable Elements as Enhancers in Mouse and Human Trophoblast"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Ana Boskovic (University of Massachusetts Medical School, USA)
"Control of Non-Coding RNA Production and Histone Levels by a 5'tRNA Fragment"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Bryony Leeke (The Francis Crick Institute, United Kingdom)
"Using Metatherians to Elucidate the Evolution of Mammalian Epigenetic Pathways"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Mary Gehring (Whitehead Institute for Biomedical Research, MIT, USA) and Petra Hajkova (MRC London Institute of Medical Sciences, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA-Mediated Epi-Regulation
Discussion Leader: Robin Allshire (Wellcome Centre for Cell Biology, University of Edinburgh, United Kingdom)
7:30 pm - 7:50 pm
Mary Gehring (Whitehead Institute for Biomedical Research, MIT, USA)
"Small RNAs and Dosage Interactions in Plants"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Steven Jacobsen (University of California, Los Angeles / Howard Hughes Medical Institute, USA)
"Epigenetic Gene Regulation in Arabidopsis "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
John Kim (Johns Hopkins University, USA)
"Sexually Dimorphic Expression of piRNAs in C. elegans "
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Upasna Sharma (University of California, Santa Cruz, USA)
"Paternal Contributions to Offspring Health: Intergenerational Epigenetic Inheritance via Sperm Small RNAs"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Programming Future Generations
Discussion Leader: Margaret Fuller (Stanford University School of Medicine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Daniel Jarosz (Stanford University, USA)
"Remembering the Past: A New Form of Protein-Based Epigenetics"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Petra Hajkova (MRC London Institute of Medical Sciences, United Kingdom)
"Molecular Principles of Developmental Reprogramming and Gametogenesis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Frederic Berger (Gregor Mendel Institute, Austria)
"Heterochromatin Establishment by the Chromatin Remodeling Factor DDM1 in Arabidopsis "
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Sandro Baldi (Ludwig Maximilian University of Munich, Germany)
"Principles of Nucleosome Phasing Revealed by Genome-Wide Mapping and In Vitro Reconstitution"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Chad Cockrum (University of California, Santa Cruz, USA)
"The C. elegans MES Chromatin Regulators Ensure Germline Survival by Repressing the X Chromosomes"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Brandon Carpenter (Emory University, USA)
"SPR-5; MET-2 Maternal Reprogramming Antagonizes H3K36me3 in the Control of Germline Versus Soma"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Reprogramming During Development
Discussion Leader: Bradley Cairns (University of Utah, USA)
7:30 pm - 7:50 pm
Richard Davis (University of Colorado School of Medicine, USA)
"Programmed DNA Elimination: Silencing Germline-Expressed Genes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Wei Xie (Tsinghua University, China)
"Epigenetic Inheritance and Reprogramming in Early Mammalian Development"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Robin Allshire (Wellcome Centre for Cell Biology, University of Edinburgh, United Kingdom)
"Establishment and Maintenance of Specialized Chromatin Domains"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Julie Ahringer (University of Cambridge, United Kingdom)
"Distinct Architectures of Germ Line and Somatically Expressed Genes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Memory and Maintenance
Discussion Leader: Hiroyuki Sasaki (Kyushu University, Japan)
9:00 am - 9:20 am
Sandra Duharcourt (Institut Jacques Monod, France)
"Epigenetic Control of Programmed Genome Rearrangements in Paramecium "
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Claudia Kohler (Linnean Center for Plant Biology, Sweden)
"Domestication of Transposable Elements for Plant Reproduction"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Soichi Inagaki (National Institute of Genetics, Japan)
"Control of Convergently Transcribed Genes Through Modulating Gene-Body Chromatin Modifications"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Satoshi Namekawa (Cincinnati Children's Hospital Medical Center, USA)
"Super-Enhancer Switching Drives a Burst in Germline Gene Expression at the Mitosis-to-Meiosis Transition"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Matthew Wooten (Johns Hopkins University, USA)
"Biased Fork Movement Coupled with Strand-Specific Histone Incorporation Ensures Asymmetric Histone Inheritance"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Daniel Saxton (University of California, Berkeley, USA)
"Epigenetic Inheritance Independent of Asymmetric Histone Inheritance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Margaret Fuller (Stanford University School of Medicine, USA)
"Regulation of Differentiation by Novel Chromatin Remodelers and Promoters"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Biophysics and Mathematical Models
Discussion Leader: Frederic Berger (Gregor Mendel Institute, Austria)
7:30 pm - 7:50 pm
Mario Nicodemi (Università Degli Studi di Napoli Federico II, Italy)
"Polymer Physics Predicts the Impact of Structural Variants on Chromatin 3D Architecture"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Martin Howard (John Innes Centre, United Kingdom)
"Modeling Polycomb-Mediated Epigenetic Silencing"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Bing Zhu (Institute of Biophysics, Chinese Academy of Sciences, China)
"Kinetics of DNA Maintenance Methylation at Single Molecule Level and Underlying Mechanisms"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Francois Spitz (University of Chicago, USA)
"3D Chromatin Organization and Gene Regulation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Environmental Influences
Discussion Leader: Amander Clark (University of California, Los Angeles, USA)
9:00 am - 9:20 am
Caroline Dean (John Innes Centre, United Kingdom)
"Antisense-Mediated Chromatin Regulation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Blanche Capel (Duke University, USA)
"Epigenetic Regulation of Sex Determination"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Yan Li (University of Texas Southwestern Medical Center, USA)
"Cellular Heterogeneity in Circadian Oscillation Driven by DNA Methylation and Transcriptional Noise"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ueli Grossniklaus (University of Zurich, Switzerland)
"A Role for Epigenetic Reprogramming During Meiosis in Plants"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Kamila Delaney (University of Geneva, Switzerland)
"H3.3K27M-Induced Chromatin Changes Drive Ectopic Replication Through Misregulation of the JNK Pathway"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Sara Martire (University of Texas Southwestern Medical Center, USA)
"Phosphorylation of Histone H3.3 at Serine 31 Promotes p300 Activity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genome Function and Disease
Discussion Leader: Susan Gasser (Friedrich Miescher Institute for Biomedical Research, Switzerland)
7:30 pm - 7:50 pm
Marnie Blewitt (The Walter and Eliza Hall Institute of Medical Research, Australia)
"Unexpected Contributors to the Establishment of X Inactivation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
John Pospisilik (Max Planck Institute of Immunobiology and Epigenetics, Germany / Van Andel Research Institute, USA)
"(Epi)genetic Control of Phenotypic Variation and Disease Heterogeneity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Erica Watson (University of Cambridge, United Kingdom)
"Mechanisms of Transgenerational Epigenetic Inheritance"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Richard Festenstein (Imperial College London, United Kingdom)
"Key Role for HUSH in Triplet-Repeat Silencing in Disease?"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure