Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Chromatin Structure
Discussion Leader: Maria-Elena Torres-Padilla (Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Germany)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Ting (C-ting) Wu (Harvard Medical School, United States)
"Pairing: a 300 Million Year-Old Mystery, a Century-Old Observation, and Super-Resolution Imaging."
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Genevieve Almouzni (Institut Curie / CNRS, France)
"H3 Variants, Replication, Genome Architecture and Cell Fate"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Maya Capelson (San Diego State University, United States)
"Nuclear Pores as Platforms for Transcriptional Memory"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Max Haase (NYU Langone Health, United States)
"The Intermediate State of Point Centromere Evolution"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
RNA-Directed Processes
Discussion Leader: R. Keith Slotkin (Donald Danforth Plant Science Center, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Blake Meyers (Donald Danforth Plant Science Center, United States)
"The Other 24-nt siRNAs in Plants: Reproductive PhasiRNAs"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Hailing Jin (University of California, Riverside, United States)
"Cross-Kingdom RNA Trafficking Between Plants and Fungal Pathogens"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Alyson Ashe (The University of Sydney, Australia)
"Understanding Transgenerational Epigenetic Inheritance Dynamics and Heterogeneity"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Pierre Baduel (ENS / CNRS, France)
"Mechanisms and determinants of epigenetic variation at TE sequences in A. thaliana "
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
Chuan He (University of Chicago, United States)
"Transcription Regulation through Reversible RNA Methylation"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Robert Martienssen (Cold Spring Harbor Laboratory, United States)
"RNA Interference and the Drive for Maize Domestication"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Mary Goll (University of Georgia, United States) and Robin Allshire (Wellcome Centre for Cell Biology, University of Edinburgh, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Heterochromatin
Discussion Leader: Susan Gasser (ISREC Foundation, Switzerland)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Bas van Steensel (Netherlands Cancer Institute, The Netherlands)
"Dissecting the 3D and Functional Organization of a Genomic Locus by Hopping and Scrambling."
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Jerome Dejardin (IGH, CNRS, France)
"Heterochromatin Flavors"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Colin Kunze (Boston University, United States)
"Engineering Epigenetic Circuits to Uncover Principles of Adaptability and Robust Inheritance in S. pombe "
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Shiv Grewal (National Cancer Institute, NIH, United States)
"Transmitting Epigenetic Memory through Methylated Histones"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenome Maintenance
Discussion Leader: Steve Jacobsen (University of California, Los Angeles, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Anja Groth (Center for Protein Research (CPR), University of Copenhagen, Denmark)
"Inheritance of Histone Modifications and Variants across DNA Replication and Mitosis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Julie Law (Salk Institute for Biological Studies, United States)
"Controlling the Epigenome One CLSY at a Time"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Giovana Maria Breda Veronezi (University of Colorado Anschutz Medical Campus, United States)
"Nucleation and Spreading Renew Polycomb Domains Every Cell Cycle"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Oladimeji Olaluwoye (The University of Texas at Dallas, United States)
"Solution Dynamics of Nucleosomes Using HDX"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
Sophie Polo (Epigenetics & Cell Fate Centre, Paris, France)
"Epigenome Maintenance in Response to DNA Damage"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Hiten Madhani (University of California, San Francisco, United States)
"Intrinsic Mesoscale Properties of a Polycomb Protein Underpin Heterochromatin Fidelity"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transposable Elements Shaping the Genome
Discussion Leader: Mary Goll (University of Georgia, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Deborah Bourc'his (Institut Curie, France)
"Retrotransposon Control in Mammalian Development and Reproduction"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Vincent Colot (Institut de Biologie de l'Ecole Normale Supérieure (IBENS), France)
"Transgenerational Epigenetic Variation in Nature"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Brandon Boone (UCLA, United States)
"Mechanism of Silencing by Methyl DNA Binding Proteins in Arabidopsis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Sihem Cheloufi (University fo California Riverside, United States)
"Manipulation of Chromatin Accessibility Reveals Selective Epigenetic Regulation of Retrotransposons"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Anne Ferguson-Smith (University of Cambridge, United Kingdom)
"The Genetics of Epigenetic Variation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Information in Development
Discussion Leader: Haruhiko Koseki (RIKEN Center for Integrative Medical Sciences, Japan)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Wolf Reik (Altos Labs Cambridge Institute of Science, United Kingdom)
"Single Cell Multi-omics Landscape of Development and Ageing"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Camila dos Santos (Cold Spring Harbor Laboratory, United States)
"Epigenetic Regulation of Mammary Epithelial Cell Lineage Identities"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Jitendra Thakur (Emory University, United States)
"Organization of Centromeric Chromatin and Pericentric Heterochromatin on DNA Satellite Arrays in House Mouse"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Ryan Lister (University of Western Australia, Australia)
"Learning to Forget: Erasing Somatic Epigenetic Memory in Human Cell Reprogramming"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
martina begnis (EPFL, Switzerland)
"Lineage-specific Gene Clusters are Regulated by ZNF274-Repressive Anchoring in the Perinucleolar Compartment"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Edith Heard (EMBL European Molecular Biology Laboratory, Germany)
"The Epigenetic Dynamics of Gene Silencing and Escape from X Inactivation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Giacomo Cavalli (Institute of Human Genetics, CNRS and University of Montpellier, France)
"Epigenetic Regulation of the Memory of Cell Fates during Development"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Programming and Reprogramming for the Next Generation
Discussion Leader: Frederic Berger (Gregor Mendel Institute, Austria)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Bradley Cairns (University of Utah, United States)
"Roles and Mechanisms of the Dux Transcription Factor in Early Embryo Chromatin Programming"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Giacomo Furlan (Lunenfeld Tanenbaum Research Institute, Canada)
"Dissecting epigenetic mechanisms of the intergenerational impact of gestational starvation"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Teresa Lee (University of Massachusetts Lowell, United States)
"The Transgenerational Accumulation of Repressive H3K9me2 Affects Health and Lifespan in C. elegans "
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Kaushik Ragunathan (Brandeis University, United States)
"Uncoupling HP1 functions during heterochromatin establishment and maintenance"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Frederic Berger (Gregor Mendel Institute, Austria)
"Polybomb Beside Yere Silencing"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Epigenetic Inheritance Between Generations
Discussion Leader: Ueli Grossniklaus (University of Zurich, Switzerland)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Danesh Moazed (Harvard Medical School, United States)
"Pathways for Epigenetic Inheritance of Heterochromatin"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Bluma Lesch (Yale University, United States)
"Modeling Epigenetic Inheritance of Cancer Susceptibility in Mammals"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Colette Picard (University of California, Los Angeles, United States)
"MORC-1 is a Key Component of the C. elegans CSR-1 Germline Gene Licensing Mechanism"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Hironori Funabiki (The Rockefeller University, United States)
"Mitotic Suppression of Histone H3.3 Deposition at the Telomeres of q Arms"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
Haruhiko Koseki (RIKEN Center for Integrative Medical Sciences, Japan)
"CpG Island-Bound SKP1A Links EED with Proteasomal Degradation and Gene Activation of Polycomb Target Genes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Zachary Harvey (Gregor Mendel Institute, Austria)
"Deep Eukaryotic History Reveals H2A.Z's Ancient Role in Setting the Transcription Potential of Chromatin"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Katherine Duval (University of Georgia, United States)
"Dynamics of H3K9me3 Enrichment at Transposable Elements in Embryogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Scott Kennedy (Harvard Medical School, United States)
"Poly(UG)-tailed RNAs in Genome Protection and Epigenetic Inheritance"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetics at the Interface Between the Genome and the Environment
Discussion Leader: Robin Allshire (Wellcome Centre for Cell Biology, University of Edinburgh, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Jose Gutierrez-Marcos (University of Warwick, United Kingdom)
"Molecular Mechanisms Underpinning Predictable and Stable Epimutations in Clonal Plants"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Christina Steadman (Los Alamos National Laboratory, United States)
"The Complex Role of DNA Methylation in Microalgae"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Germano Cecere (Institut Pasteur, France)
"Soma-to-Germline Small RNA Transfer Promotes Intragenerational Survival to Environmental Stress"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Eric Miska (University of Cambridge, United Kingdom)
"Epigenetics in Plasticity, Inheritance and Civergence in African Rift Lake Cichlids"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
