| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE SESSION: DEVELOPMENT, DIFFERENTIATION AND DISEASE IN STRATIFIED EPITHELIA |
| Discussion Leader: Henry Sun (NYU) |
| 7:30 pm - 8:00 pm | Dennis Roop (Baylor)
"Genetic Pathways Driving Skin Function and Dysfunction" |
| 8:00 pm - 8:30 pm | John Stanley (Univ. Penn)
"Targeting of Desmoglein Causes Identical Blisters in Pemphigus and Impetigo" |
| 8:30 pm - 9:00 pm | Stuart Yuspa (NIH/NCI)
"Signaling Pathways that Influence the Pathogenesis of Cutaneous Squamous Cell Cancer" |
| 9:00 pm - 9:30 pm | Henry Sun (NYU)
"Uroplakins: Functional and Disease Implications" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | CELL FATE AND STEM CELL BIOLOGY IN EMBRYOGENESIS AND IN THE ADULT: IMPLICATIONS FOR GENE THERAPY |
| Discussion Leader: Fiona Watt (ICRF) |
| 9:00 am - 9:30 am | John Gearhart (Johns Hopkins)
"Stem Cell Biology and Cell Fate Decisions in Embryogenesis" |
| 9:30 am - 10:00 am | Fiona Watt (ICRF)
"Epidermal Stem Cell Compartment and its Regulation" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Yann Barrandon (Lausanne Univ.)
"Multipotent Stem Cells and Renewal of Hair Follicles" |
| 11:00 am - 11:30 am | Michele De Luca (The Veneto Eye Bank Foundation)
"Human Limbal Stem Cells: from Clones to Clinics" |
| 11:30 am - 12:30 pm | WORKSHOP AND PANEL DISCUSSION: "STEM CELLS AND STEM CELL PLASTICITY" |
| Moderators: |
| Pritinder Kaur (Peter MacCallum Cancer Inst) & Jackie Bickenbach (Univ. Iowa) |
| Discussants: |
| Daniel Aberdam (INSERM)
"Derivation of keratinocyte progenitor cells from embryonic stem (ES) cells" |
| Jeff Miner (Washington Univ., St. Louis)
"Roles for LN-10/11 in organizing crypt-villus architecture and in regulating intestinal epithelial cell differentiation" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I: Stem Cells and Differentiation/Signaling |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MORPHOGENESIS AND REGULATION OF EPIDERMS AND ITS APPENDAGES |
| Discussion Leader: Angela Christiano (Columbia) |
| 7:30 pm - 8:00 pm | Sarah Millar (Univ. Penn.)
"WNT Signals in Hair Follicle, Tooth and Mammary Gland Development" |
| 8:00 pm - 8:30 pm | John Wysolmerski (Yale)
"The Regulation of Embryonic Mammary Gland and Nipple Development by Parathyroid Hormone-related Protein" |
| 8:30 pm - 9:00 pm | Joan Brugge (Harvard)
"Control of Cell Growth and Death in Mammary Epithelium" |
| 8:30 pm - 9:30 pm | Angela Christiano (Columbia) / My Mahoney (Thomas Jefferson)
"The Growing Family of Desmosomal Cadherins: and Then There Were Four" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | KEITH PORTER SESSION ON EPITHELIAL CYTOSKELETON AND POLARITY: BIOLOGICAL STRUCTURE AND IMAGING IN THE EPITHELIUM |
| 9:00 am - 9:10 am | Introduction on Keith Porter: Robert D. Goldman (Northwestern) |
| 9:10 am - 9:40 am | Robert D. Goldman (Northwestern)
"Dynamics of the Keratinocyte Cytoskeleton" |
| 9:40 am - 10:10 am | Pierre Coulombe (Johns Hopkins)
"Keratins and Keratinocyte Polarity During Wound Healing" |
| 10:10 am | Coffee Break |
| 10:40 am - 11:10 am | Glynis Scott (Univ. Rochester)
"Melanosome Transfer to Keratinocytes: Critical Role of Filopodia and Actin" |
| 11:10 am - 11:40 am | Jeff Simske (Rammelkamp Center)
"Epithelial Rearrangements in C. Elegans" |
| 11:40 am - 12:10 pm | W. James Nelson (Stanford)
"Cell-cell Adhesion in Simple Epithelia" |
| 12:10 pm - 12:30 pm | Short talk: Anne Muesch (Cornell U. Med. College)
"PAR-1 as an organizer of epithelial lumen" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I continued: Stem Cells and Differentiation/Signaling |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ISSUES RISING I: SIGNALING, GROWTH AND DEATH IN EPITHELIA |
| Discussion Leaders: Tony Oro (Stanford) / Mitch Denning (Loyola) |
| Short Talks (12 min) |
| Tony Oro (Stanford)
"Regulation of Gli function during hair growth and tumorigenesis" |
| Casey Moulson (Washington U., St. Louis)
"Positional cloning of wrinkle-free, a novel mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development" |
| Julie Segre (NHGR/NIH)
"Ectopic Klf4 accelerates barrier acquisition" |
| Bruce Herron (Wadworth Center)
"A mutation in Nkx/NFkB interacting protein 1 results in abnormal skin development and dilated cardiomyopathy" |
| Adam Glick (NCI)
"Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion of keratinocytes through inhibition of TGFbeta/BMP signaling and induction of EGF receptor ligands" |
| Yinling Hu (MD Anderson)
"An essential function of IKKa in maintaining genomic integrity is through p53-independent regulation of the G2/M phase of the cell cycle" |
| Mitch Denning (Loyola)
"Apoptosis and Mitotic Catastrophe in Human Keratinocytes Expressing the Protein Kinase C Delta Catalytic Domain" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ADHESION AND ADHESION-RELATED SIGNALING IN EPITHELIAL DIFFERENTIATION, MIGRATION AND DISEASE |
| Discussion Leader: Jouni Uitto (Thomas Jefferson Univ.) |
| 9:00 am - 9:30 am | Jouni Uitto (Thomas Jefferson Univ.)
"Inherited and Autoimmune Diseases of Adhesion" |
| 9:30 am - 10:00 am | Arnoud Sonnenberg (Netherlands Cancer Inst.)
"Integrin-Based Adhesion in the Epidermis" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Takao Sakai (Max Planck Inst., Martinsried)
"Role of Integrin-Linked Kinase in the Skin" |
| 11:00 am - 11:30 am | Frans van Roy (Ghent Univ.)
"Adhesion in Invasion and Cancer" |
| 11:30 am - 12:00 pm | Paolo Dotto (Harvard)
"Integrated Control of Keratinocyte Cell-cell Adhesion, Growth and Differentiation" |
| 12:00 pm - 12:20 pm | Short Talk: William Carter (Fred Hutchison)
"Adhesion-dependent tyrosine dephosphorylation of a novel membrane glycoprotein gp140/CDCP1 is an early event in epidermal wound activation" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II: Hair & Development; Adhesion/Cytoskeleton |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | EPITHELIAL DEFENSE FROM THE INSIDE OUT |
| Discussion Leader: Birgit Lane (Univ. Dundee) |
| 7:30 pm - 8:00 pm | Birgit Lane (Univ. Dundee)
"Keratins as Defensive Structures" |
| 8:00 pm - 8:30 pm | Shoichiro Tsukita (Univ. Kyoto)
"Tight Junctions and the Epidermal Barrier" |
| 8:30 pm - 9:00 pm | Richard Gallo (UCSD)
"Cutaneous Defensins" |
| 9:00 pm - 9:30 pm | William Parks (Wash U. St. Louis)
"Proteolysis and Epithelial Defense in Lung" |
| Business Meeting: Election of 2005 Vice Chair |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SIGNALING PATHWAYS IN EPITHELIAL DEVELOPMENT, DIFFERENTIATION AND DISEASE |
| Discussion Leader: Elaine Fuchs (Rockefeller Univ.) |
| 9:00 am - 9:30 am | Avri Ben Ze'ev (Weizmann Institute)
"Novel Targets of Cadherin-Catenin Signaling in Oncogenesis" |
| 9:30 am - 10:00 am | Paul Khavari (Stanford)
"Control of Epidermal Growth and Differentiation by Ras Effector Pathways" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Anj Dlugosz (Univ. of Michigan)
"Hedgehog Signaling in Hair Follicle Growth and Neoplasia" |
| 11:00 am - 11:30 am | Paul Overbeek (Baylor)
"Characterization of a TNF-related Signal Transduction Cascade Required for Primary Hair Follicle and Sweat Gland Induction" |
| 11:30 am - 12:00 pm | Elaine Fuchs (Rockefeller Univ)
"Stem Cell Lineages in the Skin" |
| 12:00 pm - 12:20 pm | Short Talk: Frank McKeon (Harvard)
"p63 and epithelial stem cell maintenance: how far upstream?" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II continued: Hair & Development; Adhesion/Cytoskeleton |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ISSUES RISING II: ADHESION, CYTOSKELETON AND DISEASES OF EPITHELIA |
| Discussion Leaders: Andrew Kowalczyk (Emory) / Masa Amagai (Keio Univ.) |
| Short Talks (12 min) |
| Masa Amagai (Keio U)
"Is desmoglein 4 an autoimmune target in pemphigus?" |
| Andrew Kowalczyk (Emory)
"'Cellular Levels of p120-catenin Function as a Set Point for Cadherin Expression Levels in Microvascular Endothelial Cells'" |
| Jonathan Garlick (SUNY, Stony Brook)
"Abrogation of E-Cadherin-mediated adhesion directs the transition to malignancy in three-dimensional models of human stratified squamous epithelium" |
| Spiro Getsios (Northwestern Univ.)
"Distinguishing between desmoglein mediated adhesion and differentiation in human keratinocytes; a unique role for desmoglein 1" |
| Matthew Hardman (Univ. Manchester)
"Misexpression of desmocollin3 in transgenic mice alters cytoplasmic -catenin levels and intracellular signalling" |
| Michael DiPersio (Albany Med.)
"Integrin alpha3 beta1 regulates MMP-9 gene expression and cadherin levels in immortalized epidermal keratinocytes" |
| David Owens (Cancer Res, UK)
"Suprabasal a6b4 integrin expression in epidermis results in enhanced tumorigenesis and disruption of TGFb signaling" |
| CLOSING REMARKS: PERSPECTIVES AND PROSPECTS |
| Robert Lavker (Northwestern University) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
