SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff and Conference Chair |
7:45 pm - 9:30 pm | Perspectives on Relevant Paradigms |
| Discussion Leader: Raphael Kopan (Washington University, St. Louis, USA) |
7:45 pm - 8:10 pm | Denis Duboule (University of Geneva, Switzerland) "Large Scale Gene Regulation During Mammalian Development" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Hans Clevers (Netherlands Institute for Developmental Biology) "Lgr5 Family Members as Adult Stem Cell Markers" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Paul Martin (Univ. Bristol, United Kingdom) "Studies of Skin Healing in Mice, Fish, and Flies" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Welcome Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stem Cells: Mobilization, Regulation, and Disease Implications |
| Discussion Leader: George Cotsarelis (Univ. of Pennsylvania, Philadelphia, USA) |
9:00 am - 9:20 am | Elaine Fuchs (Rockefeller Univ., USA) "The Stem Cell Niche of the Hair Follicle" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Yann Barrandon (Ecole Polytechnique Lederale de Lausanne, Switzerland) "Crossing Lineage Boundaries" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Jonathan Vogel (National Cancer Institute, USA) "Human Keratinocyte Stem Cells and Tumor Initiating Cells in Human Squamous Cell Carcinoma" |
10:20 am - 10:30am | Discussion |
10:30 am | Coffee Break |
11:00am - 11:20 am | Fiona Watt (Cambridge Research Institute, United Kingdom) "Engineering the Epidermal Stem Cell Niche in Vitro" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Carlos Lopez-Otin (Universidad de Oviedo, Spain) "Proteases, Aging, and Stem Cells: Messages in the Nuclear Envelope" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | George Cotsarelis (University of Pennsylvania, USA) "Hair Follicle Stem Cells and Skin Regeneration" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Genome Biology |
| Discussion Leader: Paul Khavari (Stanford University, Palo Alto, USA) |
5:30 pm - 5:50 pm | Harinder Singh (University of Chicago, USA) "Transcriptional Repression Mediated by Tethering of Genes to the Inner Nuclear Membrane-Lamina Compartment" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Julie Segre (Natl Human Genome Research Institute, USA) "The Skin is a Microbiological Zoo" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Bogi Andersen (UC Irvine, California, USA) "Clock Genes and the Hair Growth Cycle" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Paul Khavari (Stanford University, Palo Alto, USA) "Epigenetic Regulators of Epidermal Homeostasis" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Insight in Keratinocyte and Skin Biology |
| Discussion Leader: Sabine Werner (ETH, Zurich, Switzerland) |
9:00 am - 9:20 am | Michael Caterina (Johns Hopkins University, USA) "Sensory Roles for Transient Receptor Potential Ion Channels in Keratinocytes" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Randall Johnson (UC San Diego, California, USA) "The Role of Oxygen Sensing in the Skin: A key Role in Systemic Physiology" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Janice Brissette (Mass General Hospital & Harvard Univ., Boston, USA) "Epithelial Blueprints Determine Patterns of Pigmentation" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Dennis Roop (University of Colorado, Denver, USA) "Genetic Pathways Regulating Skin Morphogenesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Tony Oro (Stanford University, Palo Alto, USA) "Novel Determinants of Hedgehog Signaling in Hair Morphogenesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Sabine Werner (Institute of Cell Biology, ETH Zurich, Switzerland) "Mesenchymal-Epithelial Interactions in Wound Healing and Skin Cancer" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Issues Arising Session 1 (Short talks selected from Posters) |
| Discussion Leaders: Tudorita Tumbar (Cornell University, New York, USA) and Angela Christiano (Columbia University, New York, USA) |
5:30 pm - 5:40 pm | Tudorita Tumbar (Cornell University, New York, USA) "Dynamic Regulation of Adult Hair Follicle Stem Cells during Normal Tissue Homeostasis" |
5:40 pm - 5:45 pm | Discussion |
5:45 pm - 5:55 pm | Maria Morasso (NIAMS / NIH, Bethesda, MD) "Role of Dlx3 in hair cycling" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:10 pm | Sandra Blanco (Wellcome Trust Center for Stem Cell Research, Cambridge, UK) "The methyltransferase Misu (Nsun2) regulates epidermal lineage commitment" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:25 pm | Colin Jahoda (Univ. Durham, UK) "KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal
fate in developing mouse skin" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Isaac Brownell (Sloan-Kettering Memorial Cancer Center, New York, USA) "Hedgehog-responding stem cells in the bulge maintain the cycling hair follicle and
participate in wound healing" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 6:55 pm | Natalia Botchkareva (Univ. Bradford, UK) "MicroRNAs (miRNA) in hair-cycle-dependent gene regulation, hair growth control, and associated tissue remodeling" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Ruth Schmidt-Ullrich (Max Delbrück Center for Molecular Medicine, Germany) "Mutual requirements of Eda A1/Edar/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Angela Christiano (Columbia University, New York, USA) "Too many bristles, too much hair" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling in Development and Tissue Homeostasis |
| Discussion Leader: Cheng-Ming-Chuong (Univ. of Southern California, USA) |
9:00 am - 9:20 am | Raphael Kopan (Washington University, St-Louis, USA) "The Tumor Suppressor Activity of Notch in Epidermal Cells" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 pm | Bruce Morgan (Mass General Hospital & Harvard Univ., Boston, USA) "Signaling from the Dermal Papilla Directs Keratinocyte Stem Cell Behavior and Hair Morphogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Sarah Millar (University of Pennsylvania, USA) "Molecular Controls of Ectodermal Appendage Development" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Paolo Dotto (Université de Lausanne, Switzerland) "Notch Tumor Suppresson Function in the Skin and Beyond" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Irma Thesleff (University of Helsinki, Finland) "Epithelial-Mesenchymal Signaling in the Development of Ectodermal Appendages" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Cheng-Ming Chuong (Univ. of Southern California, Los Angeles, USA) "Macro-Environmental Regulation of Hair Stem Cell Activity" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Mechanistic Insight into Complex Cellular Processes |
| Discussion Leader: Kathy Green (Northwestern University, Chicago, USA) |
5:30 pm - 5:50 pm | Zena Werb (UC San Francisco, California, USA) "The Morphogenetically Active Epithelial State: Contributions to Development and Tumorigenesis" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Howard Chang (Stanford University, Palo Alto, USA) "Genomic Encoding of Positional Identities" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Kathy Green (Northwestern University, Chicago, USA) "Desmoglein 1 Coordinates Epidermal Differentiation and Morphogenesis via Adhesion-Independent Mechanisms" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Stuart Yuspa (Natl Cancer Institute, Bethesda, USA) "CLIC4 and TGFbeta; Surprising Connections in epithelial Differentiation and Skin Cancer Pathogenesis" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Disease Pathophysiology & Therapeutic Approaches |
| Discussion Leader: David Woodley (University of Southern California, Los Angeles, USA) |
9:00 am - 9:20 am | Steve Young (UC San Francisco, California, USA) "Therapeutic Approaches for Lamin-Based Premature Aging Disorders" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Michele DeLuca (Univ. of Modena & Reggio Emilia, Italy) "Towards Gene Therapy for Epidermolysis Bullosa" |
9:50 am - 10:00am | Discussion |
10:00 am - 10:20 am | Masa Amagai (Keio University, Tokyo, Japan) "Pemphigus: A Dynamic Model of Autoimmune Responses" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Irwin McLean (University of Dundee, United Kingdom) "Filaggrin-Based Disorders; A Major Impact on Skin and Human Health" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Shigetoshi Sano (University of Osaka, Japan) "Impact of Stat3 on Skin Biology" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | David Woodley (University of Southern California, Los Angeles, CA, USA) "Gene, Vector, Cell and Protein Therapy with Type VII Collagen Reverse Dystrophic EB and Promote Wound Healing" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Issues Arising Session 2 (Short talks selected from Posters) |
| Discussion Leaders: Rhadika Atit (Case Western Reserve, Cleveland, USA) and Anj Dlugosz (University of Michigan, Ann Arbor, USA) |
5:30 pm - 5:40 pm | Rhadika Atit (Case Western Reserve, Cleveland, USA) "Signaling Requirements for Dermal Development" |
5:40 pm - 5:45 pm | Discussion |
5:45 pm - 5:55 pm | Sylvia D’Alessio (San Raffaele Scientific Institute, Italy) "The role of uPAR in skin homeostasis and cancer development" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:10 pm | Daryle DePianto (Johns Hopkins University, Baltimore, MD) "Keratin 17 impacts skin epithelial hyperplasia via modulation of inflammation" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:25 pm | Stephen Jane (Univ. Melbourne, Australia) "Defective wound healing in mice lacking planar cell polarity genes" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Colin Jamora (Univ. California San Diego, CA, USA) "Epidermal Caspase-8 Regulates a Wound Healing Response" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 6:55 pm | Sunny Wong (Univ. California San Francisco, CA) "Primary Cilia Can Both Promote and Suppress Hedgehog-Mediated Skin Tumorigenesis" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Terry Lechler (Duke University, Durham, NC, USA) "Control of Asymmetric Cell Division in the Developing Epidermis" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Anj Dlugosz (University of Michigan, Ann Arbor, USA) "Sending Mixed Signals; Hh-Wnt Interactions During Skin Tumorigenesis" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |