SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Sensory Epithelia |
| Discussion Leaders: Ellen Lumpkin (Columbia University) and Mingang Xu (University of Pennsylvania) |
7:40 pm - 8:20 pm | Keynote: Charles Zuker (Columbia University)
"The Biology of Mammalian Taste: from the Tongue to the Brain" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Keynote: David Ginty (Johns Hopkins University)
"The Skin as a Sensory Organ" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stem Cells and Regeneration |
| Discussion Leaders: Tudorita Tumbar (Cornell University) and Panteleimon Rompolas (Yale University) |
9:00 am - 9:20 am | Elaine Fuchs (Rockefeller University)
"Skin Stem Cells and Tumor Progression" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Fiona Watt (King's College, London)
"Investigation of Dermal Cell Heterogeneity" |
9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Pritinder Kaur (Peter MacCallum Cancer Centre, Melbourne)
"Pericytes in the Tumour Microenvironment act as Potent Regulators of Epithelial Tumor Growth Rate and Metastatic Spread" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | George Cotsarelis (University of Pennsylvania)
"Molecular and Cellular Mechanisms of Skin Regeneration" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Valerie Horsley (Yale University)
"The Role of Intradermal Adipocytes in the Skin" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Bruce Morgan (Massachusetts General Hospital)
"Regulating Dermal Papilla Cell Number in Development and Disease to Specify Hair Morphology" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | Epithelial Cytoskeleton, Adhesion and Polarity |
| Discussion Leaders: Danelle Devenport (Princeton University) and Oksana Nekrasova (Northwestern University) |
5:30 pm - 5:50 pm | Carien Niessen (University of Cologne)
"Insulin/IGF Mediated Control of Epidermal Morphogenesis and Stem Cell Behavior" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Danelle Devenport (Princeton University)
"Establishing and Maintaining Planar Polarity in the Mammalian Epidermis" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Kathy Green (Northwestern University)
"Coupling Desmosomes with Cytoskeletal Organization during Epidermal Morphogenesis" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Keynote: Pierre Coulombe (Johns Hopkins University) [in memory of Irwin Freedberg]
"A role for Keratins in Inflammatory and Immune Responses in Skin" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Epithelial Barriers, Inflammation, Immune Functions and the Microbiome |
| Discussion Leaders: Elizabeth Grice (University of Pennsylvania) and Shawn Demehri (Washington University) |
9:00 am - 9:20 am | Rob Knight (University of Colorado, Boulder)
"Microbes on the Skin of Humans and other Vertebrates" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Julie Segre (National Human Genome Research Institute)
"Skin Microbial Communities Integrating Genetic-Environmental Interactions" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Raphael Kopan (Washington University)
"An Update and a Revelation: New Technology Developed to Probe Target Selection by Protein Complexes In Vivo" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | David Kelsell (Barts and The London School of Medicine and Dentistry)
"High Throughput Human Disease Gene Discovery Leading to New Insights in Keratinocyte Differentiation, Inflammation and Barrier Function" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Rama Ranganathan (University of Texas Southwestern Medical Center)
"Evolutionary Principles of Protein Structure and Function" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Janina Bar (TRM University of Leipzig)
"A Genome Engineering Approach Reveals a Fundamental Role of Keratins in Epidermal Barrier Gene Expression" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Fang Liu (University of Pennsylvania)
"Histone Deacetylase 3 is Essential for Stepwise Differentiation of the Epidermis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | Development and Evo-Devo of Skin, Skin Appendages, and the Pigmentary System |
| Discussion Leaders: Radhika Atit (Case Western University) and Laura Ahtiainen (Institute of Biotechnology, Helsinki) |
5:30 pm - 5:50 pm | Gregory S. Barsh (HudsonAlpha Institute for Biotechnology)
"How the Leopard got its Spots" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Cheng-Ming Chuong (University of Southern California)
"Physiological Regeneration of Ectodermal Organs" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Marja Mikkola (Institute of Biotechnology, Helsinki)
"Molecular and Cellular Regulation of Hair Follicle Morphogenesis" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Yana Kamberov (Harvard Medical School)
"Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Mayumi Ito (NYU)
"Wnt Activation in Nail Epithelium Couples Nail Growth to Digit Regeneration" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms in Epithelial Cancer |
| Discussion Leaders: Paolo Dotto (Universite de Lausanne, MGH) and Scott Atwood (Stanford University) |
9:00 am - 9:20 am | Cedric Blanpain (Interdisciplinary Research Institute, Brussels)
"Epithelial Stem Cells during Development, Homeostasis and Regeneration" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Birgit Lane (Institute of Molecular Biology, Singapore)
"Visualising Keratinocyte Stress to Understand Rare Diseases and Wound Healing" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Paul Khavari (Stanford University)
"Genomic Reprogramming in Differentiation and Cancer" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Paolo Dotto (Universite de Lausanne, MGH)
"Notch Signaling at the Interconnection between Skin Aging and Cancer" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Andrzej Dlugosz (University of Michigan)
"Hedgehog Signaling Level, Tumor Phenotype, and Oncogene Addiction" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Laurie Littlepage (University of Notre Dame)
"The Transcription Factor ZNF217 is an Oncogene that Promotes a Progenitor Cell Phenotype, Epithelial Plasticity, and Chemoresistance during Breast Cancer" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Prabha Sampath (Institute of Medical Biology, Singapore)
"A Post-Transcriptional Switch Dictates Wound Re-epithelialization" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session III |
5:30 pm - 7:30 pm | Issues Arising Session |
| Discussion Leaders: Anthony Oro (Stanford University) and Ryan Hobbs (Johns Hopkins University) |
5:30 pm - 5:40 pm | Xinhong Lim (Stanford University)
"Interfollicular Epidermal Stem Cells Balance Self-Renewal and Differentiation by Secreting Autocrine Wnt Signals and Paracrine Wnt Inhibitors" |
5:40 pm - 5:45 pm | Discussion |
5:45 pm - 5:55 pm | Philip Jones (Medical Research Council Cancer Cell Unit, Cambridge, UK)
"Loss of Canonical Notch Signaling Confers Clonal Dominance in Esophageal Epithelium" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:10 pm | Scott Weatherbee (Yale University)
"Forward Genetics Identifies a Critical, Novel Regulator of the Epidermal Switch Between Proliferation and Differentiation" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:25 pm | Ellen Lumpkin (Columbia University)
"TRPA1 Channels Govern Keratinocyte Proliferation In Vitro and in a Mouse Model of Dry-skin-evoked Chronic Itch" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | David Owens (Columbia University)
"The Touch Dome Defines a New Niche in the Skin Epidermis" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 6:55 pm | Markus Kretz (Regensburg University)
"Control of epidermal differentiation by long noncoding RNAs" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Paul Giresi (Stanford University)
"Epigenomic profiling of rare and dynamic cell populations" |
7:10 pm - 7:15 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Novel Regulatory Mechanisms and Investigational Approaches |
| Discussion Leaders: Howard Chang (Stanford University) and Paul Giresi (Stanford University) |
9:00 am - 9:10 am | Tudorita Tumbar (Cornell University)
"Reversible transition state between adult hair follicle stem and transit amplifying cells and distinct hair cell fates driven by different Runx1 levels" |
9:10 am - 9:15 am | Discussion |
9:15 am - 9:25 am | Ruby Shalom-Feuerstein (Technion - Israel Institute of Technology)
"miR-184 represses K15 and induces epithelial stem cell differentiation" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Salvador Aznar Benitah (Centre for Genomic Regulation, Barcelona)
"Spatiotemporal Regulation of Epidermal Stem Cells by Circadian Rhythms: Impact on Homeostasis, Aging and Cancer" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Vladimir Botchkarev (Bradford University)
"Topological Genome Organization and Higher-Order Chromatin Remodeling in Epithelial Stem Cells during Differentiation and Reprogramming" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Rui Yi (University of Colorado, Boulder)
"Dynamic Regulation of Skin Development by MicroRNAs " |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Valentina Greco (Yale University)
"Live Imaging of Stem Cell Dynamics during Hair Follicle Regeneration" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Howard Chang (Stanford University)
"Hierarchical Mechanisms of Trans-Differentiation and Cell Fate Plasticity" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session IV |
5:30 pm - 7:30 pm | Novel Therapeutic Approaches |
| Discussion Leaders: David Lane (Institute of Molecular Biology, Singapore) and Xiaomin Bao (Stanford University) |
5:30 pm - 5:50 pm | Jakub Tolar (University of Minnesota)
"Bone Marrow and Cord Blood Transplantation in Epidermolysis Bullosa: Progress and Challenges" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Dennis Roop (University of Colorado, Denver)
"iPS Cell-based Therapies for Epidermolysis Bullosa" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Anthony Oro (Stanford University)
"Novel Therapeutics for Regeneration and Skin Cancer" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Keynote: David Lane (Institute of Molecular Biology, Singapore)
"Novel Inhibitors of Protein-Protein Interactions" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |