Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: New Concepts in Genetic and Epigenetic Regulation of Epithelia |
| Discussion Leaders: Maria Morasso (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA) and Scott Atwood (University of California, Irvine, USA) |
7:40 pm - 8:20 pm | Elaine Fuchs (Rockefeller University, USA) "Skin Stem Cells in Silence, Action and Cancer" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Pier Paolo Pandolfi (Beth Israel Deaconess Medical Center / Harvard Medical School, USA) "The Non-Coding RNA Revolution in Biomedical Research" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms of Epithelial Carcinogenesis |
| Discussion Leaders: Andrzej Dlugosz (University of Michigan, USA) and Shadmehr Demehri (Massachusetts General Hospital, USA) |
9:00 am - 9:20 am | Paul Khavari (Stanford University, USA) "Genomic Reprogramming in Epidermal Differentiation and Cancer" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Cedric Blanpain (University Libre de Bruxelles, Belgium) "Mechanisms Regulating Skin Cancer Initiation and Progression" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Kornelia Polyak (Dana-Farber Cancer Center, USA) "Intratumor Heterogeneity in Breast Cancer" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:10 am | Philip Jones (University of Cambridge, United Kingdom) "High Burden and Pervasive Positive Selection of Somatic Mutations in Normal Skin" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Ramon Whitson (Stanford University, USA) "Novel Hedgehog Activators Conferring Resistant BCC Growth" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Ramiro Iglesias-Bartolome (National Institute of Dental and Craniofacial Research, NIH, USA) "A Galpha-s/PKA Tumor Suppressor Pathway Restraining YAP1 and GLI in Epithelial Stem Cells" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Paolo Dotto (University of Lausanne, Switzerland) "Notch/CSL and ERβ Signaling in Skin Field Cancerization" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Sandra Iden (University of Cologne, Germany) "Novel Non-Cell Autonomous Role of Epidermal Polarity Protein Par3 in Melanocyte Homeostasis and Melanomagenesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Innovative Techniques in Epithelial Biology |
| Discussion Leaders: Vladimir Botchkarev (University of Bradford / Boston University, USA) and Hoang Nguyen (Baylor College of Medicine, USA) |
7:30 pm - 7:50 pm | Le Cong (Broad Institute, USA) "Development and Applications of CRISPR-Cas9 for Genome Editing" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Markus Delling (Boston Children's Hospital, USA) "Ion Channels in Primary Cilium" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Lorenz Studer (Memorial Sloan Kettering Cancer Center, USA) "Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Valentina Greco (Yale University, USA) "Signaling Mechanisms of Skin Regeneration and Cancer by Live Imaging" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Advances in Epithelial Homeostasis and Regeneration |
| Discussion Leaders: Pritinder Kaur (Hudson Institute of Medical Research, Australia) and Claire Higgins (Imperial College, United Kingdom) |
9:00 am - 9:20 am | George Cotsarelis (University of Pennsylvania, USA) "Hair Follicles Promote Skin Regeneration" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Fiona Watt (Kings College London, United Kingdom) "Reciprocal Signalling Between Epidermal Stem Cells and Dermal Cell Subpopulations" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Michael Rendl (Mount Sinai School of Medicine, USA) "Mesenchymal Control of Hair Follicle Formation, Growth and Regeneration" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Mayumi Ito (New York University, USA) "Regeneration of Pigmented Hair" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Russ Carstens (University of Pennsylvania, USA) "Emerging Roles for the Epithelial-Specific Splicing Regulators Esrp1 and Esrp2 in Skin Development and Epidermal Barrier Function" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | George Sen (University of California, San Diego, USA) "DDX6 Orchestrates Mammalian Progenitor Function Through the mRNA Degradation and Translation Pathways" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Michael Fessing (University of Bradford, United Kingdom) "5C Interactome Map Within the EDC Locus: Lineage-Specific Chromatin Interactions and Heterogeneity Between Distinct Topologically-Associated Domains (TADs) Regulated by Satb1 in Keratinocytes" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Panteleimon Rompolas (Yale School of Medicine, USA) "Novel Insights in the Mechanisms of Epidermal Maintenance by In Vivo Imaging" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Current Ideas in Epithelial Interactions with the Environment |
| Discussion Leaders: Raphael Kopan (Cincinnati Children's Hospital Medical Center, USA) and Ryan Hobbs (Johns Hopkins University, USA) |
7:30 pm - 7:50 pm | Masayuki Amagai (Keio University School of Medicine, Japan) "Skin Barrier Homeostasis in Stratum Corneum and Granulosum" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Peter Marinkovich (Stanford University School of Medicine, USA) "Studies on the Molecular Pathogenesis of Human Psoriasis" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Diana Bautista (University California, Berkeley, USA) "Neuronal-Keratinocyte Crosstalk in Acute and Chronic Itch" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Valerie Horsley (Yale University, USA) "Tension and Signaling: Cellular Interactions that Control Skin Function and Regeneration" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Brad Kubick (University of Colorado, Anschutz Medical Campus, USA) "Cutaneous Neoplasms Undergo a Dynamic Immunoediting Process" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Emerging Concepts in Epithelial Adhesion and Polarity |
| Discussion Leaders: Terry Lechler (Duke University Medical Center, USA) and Spiro Getsios (Northwestern University, USA) |
9:00 am - 9:20 am | Carien Niessen (University of Cologne, Germany) "The Regulation of Epidermal Cyto-Architecture in Skin Morphogenesis and Maintenance" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Tarun Kapoor (The Rockefeller University, USA) "How Nanometer-Sized Proteins Measure Dynamic Micron-Sized Geometric Features to Assemble the Cell Division Apparatus" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Pierre Coulombe (Johns Hopkins Bloomberg School of Public Health, USA) "Emerging Role for Keratins in the Regulation of Gene Expression" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Kathleen Green (Northwestern University, USA) "Structural and Functional Diversity of Desmosomes" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Dennis Discher (University of Pennsylvania, USA) "Lamin-A Responds to Matrix Elasticity, Couples to Retinoids, and
Amplifies Cell fate Decisions" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Soline Estrach (Nice Institute for Research on Cancer and Aging, France) "The Amino Acid Transporter and Integrin Co-Receptor, CD98hc, Is Required in Skin Mechanical Response In Vivo" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Sara Wickstrom (Max Planck Institute for Biology of Aging, Germany) "Mechanical Regulation of Chromatin Architecture Regulates Lineage Progression and Epidermal Development" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | New Insights in Epithelial Aging and Metabolism |
| Discussion Leaders: Birgit Lane (Institute of Medical Biology, Singapore) and Catherin Niemann (University of Cologne, Germany) |
7:30 pm - 7:50 pm | Jan Hoeijmakers (Erasmus University, The Netherlands) "DNA Damage and Repair: Key Factors for Cancer and Aging" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Michaela Frye (University of Cambridge, United Kingdom) "Epidermal Stem Cell Function and Sensitivity to Genotoxic Stress Is Controlled by Protein Translation Rates" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Amy Wagers (Harvard University, USA) "Rejuvenation of Aging Mouse Tissues by Youthful Systemic Factors" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Emi Nishimura (Tokyo Medical and Dental University, Japan) "Hair Follicle Aging and Hair Loss" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Salvador Aznar-Benitah (Institute for Research in Biomedicine, Barcelona, Spain) "Epidermal Stem Cell Aging: Lessons from Circadian Rhythms" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Conceptual Advances in Epithelial Evolution and Morphogenesis |
| Discussion Leaders: Bruce Morgan (Massachusetts General Hospital / Harvard Medical School, USA) and Catherine Lu (Rockefeller University, USA) |
9:00 am - 9:20 am | Sarah Millar (University of Pennsylvania, USA) "Molecular Controls of Epithelial Development and Regeneration" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Marja Mikkola (University of Helsinki, Finland) "Induction of Hair Follicle Formation" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Sunny Wong (University of Michigan, USA) "Cellular Rearrangements During Hair Follicle Canal Morphogenesis and Lumen Formation" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Hopi Hoekstra (Harvard University, USA) "How the Mouse Got Its Stripes" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Cheng-Ming Chuong (University of Southern California, USA) "Evo-Devo of Epithelial Appendages" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Elena Ezhkova (Icahn School of Medicine at Mount Sinai, USA) "An Unconventional Polycomb Repressive Mechanism Regulates Skin Stem Cell Maintenance and Differentiation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Ting Chen (National Institute of Biological Sciences, China) "Origin of Hair Follicle Stem Cells and Bulge Niche" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Novel Epithelial Based Therapies |
| Discussion Leaders: Luis Garza (Johns Hopkins School of Medicine, USA) and Caterina Missero (CEINGE - Biotecnologie Avanzate, Italy) |
5:30 pm - 5:50 pm | James Bradner (Dana-Farber Cancer Institute, USA) "Small-Molecule Chromatin Regulators in Cancer Therapy" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Angela Christiano (Columbia University, USA) "Pathogenesis and Therapy of Alopecia Areata" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Masayo Takahashi (RIKEN Center for Developmental Biology, Japan) "Human Retinal Cell Therapy for Macular Degeneration Using iPS Cells" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Keisuke (Chris) Nagao (National Institutes of Health, USA) "Dysbiosis Drives Atopic Inflammation" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Markus Schober (New York University School of Medicine, USA) "TGFβ Signaling Governs a Quiescent, Therapy-Resistant State in Squamous Cell Carcinomas" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |