Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Visualizing Interactions in Epithelial Homeostasis and Disease
Discussion Leaders: Kathleen Green (Northwestern University, USA) and Aaron Mertz (Rockefeller University, USA)
7:40 pm - 8:20 pm
Ronald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Using Advanced Dynamic and Multiplex Static Imaging to Understand Tissue Organization and Function"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Angela Christiano (Columbia University, USA)
"Therapeutic and Genetic Approaches to Alopecia Areata and Skin Blistering Diseases"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Homeostatic Growth and Regeneration of Epithelia: Novel Concepts in Cell Death and Renewal
Discussion Leaders: Valerie Horsley (Yale University, USA) and Maria Morasso (National Institutes of Health, USA)
9:00 am - 9:20 am
Jay Rajagopal (Massachusetts General Hospital, USA)
"Plasticity and Epithelial Regeneration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Philip Jones (The Wellcome Trust Sanger Institute, United Kingdom)
"Clonal Competition in Squamous Carcinogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Kim Jensen (University of Copenhagen, Denmark)
"Cellular Reprogramming by Defined Factors Drives Tissue Repair Following Injury of the Intestinal Epithelium"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Pantelis Rompolas (University of Pennsylvania, USA)
"Eye to Eye: Visualizing Stem Cell Activity and Regeneration of the Live Corneal Epithelium"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Elena Ezhkova (Icahn School of Medicine at Mount Sinai, USA)
"Diverse Roles of Polycomb Repressive Complexes in Epidermal Stem Cell Maintenance and Differentiation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Cory Simpson (University of Pennsylvania, USA)
"The Mitophagy Receptor NIX Is Unregulated During Epidermal Differentiation and Drives Mitochondrial Fragmentation via Drp1"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Aron Jaffe (Novartis Institutes for BioMedical Research, USA)
"Single Cell RNA-Seq Reveals a Novel Cell Type in Airway Epithelium"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Sarah Millar (University of Pennsylvania, USA)
"Distinct Functions for Class I HDACs in Epithelial Progenitor Cell Self-Renewal and Differentiation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Angela Christiano (Columbia University, USA) and Valentina Greco (Yale University, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Evolution and Morphogenesis of Skin and Its Appendages
Discussion Leaders: Cristina De Guzman Strong (Washington University School of Medicine, USA) and Bogi Andersen (University of California, Irvine, USA)
6:00 pm - 6:20 pm
Christiane Nuesslein-Volhard (Max Planck Institute for Developmental Biology , Germany)
"The Development and Evolution of Colour Patterns in Fishes"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Leopold Eckhart (Medical University of Vienna, Austria)
"Diversification of Epidermal Differentiation Proteins During the Evolution of the Skin in Mammals, Reptiles and Birds"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Cheng-Ming Chuong (University of Southern California, USA)
"Evo-Devo of Skin Stem Cells and Their Regulation"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Ting Chen (National Institute of Biological Sciences, Beijing (NIBS), China)
"Hox Demarcates Regional Regeneration of Skin"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Anthony Oro (Stanford University, USA)
"Chromatin Dynamics During Epithelial Commitment"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cancerous Growth, Migration and Invasion of Epithelia
Discussion Leaders: Pritinder Kaur (Curtin University, Australia) and Scott Atwood (University of California, Irvine, USA)
9:00 am - 9:20 am
Peter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
"Plasticity of Collective Invasion in Epithelial and Mesenchymal Cancer Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Elaine Fuchs (Rockefeller University, USA)
"Skin Stem Cells and Their Niche Interactions in Homeostasis and Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Allan Balmain (University of California, San Francisco, USA)
"Target Genes and Target Cells in Skin Cancer"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Kai Mesa (Yale University, USA)
"Live Imaging of Coordinated Epidermal Stem Cell Differentiation and Self-Renewal in Mice"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Andrzej Dlugosz (University of Michigan, USA)
"Molecular Basis of Merkel Cell Carcinoma"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Vladimir Botchkarev (University of Bradford, United Kingdom / Boston University, USA)
"Chromatin Architectural Protein CTCF Controls Epidermal Barrier Formation, Hair Follicle Cell Fate Maintenance and Suppresses Inflammatory Responses in the Epithelium of Developing and Adult Skin"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Cedric Blanpain (Universite Libre de Bruxelles, Belgium)
"Cancer Cell of Origin, Multipotency and Tumor Heterogeneity in the Mammary Gland"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Genetic and Epigenetic Determinants of Cell Fate
Discussion Leaders: Xiaomin Bao (Northwestern University, USA) and Jennifer Zhang (Duke University, USA)
6:00 pm - 6:20 pm
Douglas Winton (Cancer Research UK Cambridge Institute, United Kingdom)
"Distinguishing Plasticity from Fate During Intestinal Self Renewal"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Paul Khavari (Stanford University, USA)
"New RNA and Protein Regulators of Ras Signaling"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Ya-Chieh Hsu (Harvard University, USA)
"Emerging Roles of Hair Follicles' Transit Amplifying Cells in skin Development and Regeneration"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Brett Shook (Yale University, USA)
"Dermal Adipocyte Lipolysis Is Required for Multiple Aspects of Skin Regeneration"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Tudorita Doina Tumbar (Cornell University, USA)
"Genetic and Epigenetic Regulation of Skin Epithelial Stem Cell Lineages in and out of Their Niches"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Cell- and Tissue-Architecture Control
Discussion Leaders: Birgit Lane (Institute of Medical Biology, A*STAR, Singapore) and Srikala Raghavan (Institute for Stem Cell Biology and Regenerative Medicine, India)
9:00 am - 9:20 am
Cristina Lo Celso (Imperial College London, United Kingdom)
"Imaging Healthy and Malignant Hematopoiesis: Active Cells in a Dynamic Environment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Matthias Ruebsam (University of Cologne, Germany)
"Cadherins Are Key Determinants of Epidermal Polarity and Tension"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Marina Mapelli (European Institute of Oncology, Italy)
"NuMA:LGN Hetero-Hexamers Cluster Active Dynein Motors at the Cortex to Promote Planar Cell Divisions"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Sara Wickstrom (Max Planck Institute for Biology of Aging, Germany)
"Biomechanics of Stem Cell Fate Regulation"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Scott Williams (University of North Carolina at Chapel Hill, USA)
"Rugged Terrain: The Search for Oral Epithelial Stem Cells"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Pierre Coulombe (Johns Hopkins Bloomberg School of Public Health, USA)
"Interplay Between Intermediate Filaments and Redox Balance in Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Oxana Nekrasova (Northwestern University, USA)
"Desmosomal Cadherin Association with Tctex-1 and Contraction-Arp2/3 Drives Perijunctional Actin Polymerization to Promote Epidermal Stratification"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Terry Lechler (Duke University Medical Center, USA)
"Novel Functions for Desmosomes in the Epidermis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Stress Responses in Homeostasis and Degeneration
Discussion Leaders: Markus Schober (New York University School of Medicine, USA) and Marina Mapelli (European Institute of Oncology, Italy)
6:00 pm - 6:20 pm
Pekka Katajisto (Karolinska Institutet, Sweden / University of Helsinki, Finland)
"Age-Selective Segregation of Organelles During Stem Cell Division"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Carlos Clavel (A*Star-Institute of Medical Biology, Singapore)
"Regulation of the Hair Follicle Stem Cell Niche During Hair Growth, Pigmentation and Aging"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Michaela Frye (University of Cambridge, United Kingdom)
"Translating Epitranscriptome in Skin Stem Cells"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Kiarash Khosrotehrani (University of Queensland, Australia)
"Bimodal Evolution of Clone Size Variation in the Interfollicular Epidermis Persists upon UVB Irradiation: Implications for Carcinogenesis"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Manolis Pasparakis (University of Cologne, Germany)
"Epithelial Cell Death Pathways in Inflammatory Diseases"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Epithelia Micro-Environment in Homeostasis and Disease
Discussion Leaders: Michael Rendl (Icahn School of Medicine at Mount Sinai, USA) and Chloe Feral (INSERM, France)
9:00 am - 9:20 am
Jan Philipp Junker (Max Delbruck Center for Molecular Medicine, Germany)
"Spatial Transcriptomics and Single-Cell Lineage Tracing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Fiona Watt (King's College London, United Kingdom)
"Fibroblast Heterogeneity in Skin Homeostasis and Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Samantha Larsen (The Rockefeller University, USA) and Shruti Naik (The Rockefeller University, USA)
"Memory of Inflammation in Epidermal Stem Cells"
10:40 am - 10:45 am
Discussion
10:45 am - 11:05 am
Valentina Greco (Yale University, USA)
"Principles of Skin Tissue Regeneration by Live Imaging"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Hironobu Fujiwara (Center for Developmental Biology, RIKEN, Japan)
"Hair Follicle Epidermal Stem Cells Define a Niche for Tactile Sensation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Ellen Lumpkin (Columbia University, USA)
"Neurobiology of Touch"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
George Cotsarelis (University of Pennsylvania, USA)
"Hair Follicle Stem Cells in Androgenetic Alopecia"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Novel Translational Concepts in Epithelial Based Disease
Discussion Leaders: Sunny Wong (University of Michigan, USA) and Jiro Kishimoto (Shiseido Global Innovation Center, Japan)
6:00 pm - 6:20 pm
Julie Segre (National Human Genome Research Institute, NIH, USA)
"Translating Human Skin Microbiome Research for Primary Immune Deficiency and Atopic Dermatitis Patients"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Caterina Missero (CEINGE - Biotecnologie Avanzate / University of Naples Federico II, Italy)
"Novel Approaches to Target p63-Associated Genodermatoses"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Brian Capell (University of Pennsylvania, USA)
"Epigenetic Enhancers and SCC"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Akiharu Kubo (Keio University, Japan)
"Causative Gene Identification and Pathogenesis-Based Therapies in Genodermatoses"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Jamie Schwendinger-Schreck (University of California, Berkeley, USA)
"Neutrophils Play a Key Role in Acute and Chronic Itch"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Salvador Aznar Benitah (Institute for Research in Biomedicine (IRB Barcelona), Spain)
"Epigenetic Control of CD36+ Metastasis Initiating Cells by Dietary Fatty Acids"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure