Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Understanding Biological Systems at Different Scale Magnitudes
Discussion Leader: Guiomar Solanas (Institute for Research in Biomedicine (IRB Barcelona), Spain)
7:40 pm - 8:20 pm
Kathleen Green (Northwestern University, USA)
"How Cadherins Helped Create Complex Epithelia"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Cassandra Extavour (Harvard University, USA)
"Embryonic Bricklaying: The Nuclear Movements that Establish the Blastoderm Epithelium in Insect Embryos"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells and Homeostasis
Discussion Leaders: Marja Mikkola (University of Helsinki, Finland) and Tudorita (Doina) Tumbar (Cornell University, USA)
9:00 am - 9:20 am
Eugenia Piddini (University of Bristol, United Kingdom)
"Cell Competition in Drosophila and Mammalian Epithelia"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Elaine Fuchs (The Rockefeller University, USA)
"Skin Stem Cells: Coping with Stress"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Emi Nishimura (Tokyo Medical and Dental University, Japan)
"Stem Cell Competition in Skin Homeostasis and Aging"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Xiaomin Bao (Northwestern University, USA)
"Transcription Termination Regulates Keratinocyte Proliferation and Differentiation"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Blair Jenkins (Columbia University, USA)
"The Cellular Basis of Touch-Dome Development"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Maria Kasper (Karolinska Institutet, Sweden)
"Deciphering Skin at the Single-Cell Level"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Katie Cockburn (Yale School of Medicine, USA)
"Understanding Principles of Differentiation in the Regenerating Epidermis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Pritinder Kaur (Curtin University, Australia)
"Skin Regeneration and Ageing: Deterioration of the Microenvironment"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Salvador Aznar Benitah (Institute for Research in Biomedicine (IRB Barcelona), Spain) and Blair Jenkins (Columbia University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of Cytoarchitecture
Discussion Leader: Bogi Andersen (University of California, Irvine, USA)
7:30 pm - 7:50 pm
Jonathon Howard (Yale University, USA)
"Microtubules, Motors and Morphogenesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Srikala Raghavan (Institute for Stem Cell Biology and Regenerative Medicine, India)
"Role of Mechano-Transduction in Maintaining Stem Cell Quiescence"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Carien Niessen (University of Cologne, Germany)
"Integrating Mechanics and Signaling to Shape Epithelial Barriers"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Chih-Chiang Chen (National Yang Ming University / Taipei Veterans General Hospital, Taiwan)
"The Mystery Beyond Stem Cell Mechanobiology"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Pierre Coulombe (University of Michigan, USA)
"Keratins Impact Fundamental Processes Involving the Nucleus"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epithelial Cancers
Discussion Leaders: Amar Mirza (Stanford Medicine, USA) and Andrzej Dlugosz (University of Michigan, USA)
9:00 am - 9:20 am
Allan Balmain (University of California, San Francisco, USA)
"Normal and Cancer Stem Cells in Skin Tumor Evolution"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Philip Jones (Wellcome Sanger Institute, United Kingdom)
"Evolutionary Selection of Mutant Progenitors in Squamous Epithelia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:40 am
Geraldine Guasch (Institut Paoli-Calmettes, Cancer Research Center of Marseille, France)
"Epithelial Transition Zones: Stem Cell Niche and Cancer"
10:40 am - 10:45 am
Discussion
10:45 am - 11:05 am
Cedric Blanpain (Université Libre de Bruxelles, Belgium)
"Mechanisms Regulating Tumor Heterogeneity and EMT Transition States"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Ilaria Malanchi (The Francis Crick Institute, United Kingdom)
"Tumour-Host Interaction During Metastasis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Gian Paolo Dotto (University of Lausanne, Switzerland)
"Skin Cancer Prevention: A Look Upside-Down"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Mina Bissell (Lawrence Berkeley National Laboratory, USA)
"Extracellular Matrix: The Molecules that Rock!"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic and Nuclear Architecture
Discussion Leader: Vladimir Botchkarev (University of Bradford, United Kingdom / Boston University, USA)
7:30 pm - 7:50 pm
Michaela Frye (German Cancer Research Center (DKFZ), Germany)
"RNA Methylation Links Protein Synthesis to Cell Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Idan Cohen (Icahn School of Medicine at Mount Sinai, USA)
"Polycomb Repressive Complex 1 (PRC1) Preserves Epidermal Tissue Integrity Independently of PRC2"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Sarah Millar (University of Pennsylvania, USA)
"Mechanisms Underlying Skin Epigenetic Regulation and Heterogeneity"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Allon Klein (Harvard Medical School, USA)
"Mapping Signaling Pathway Modulation of the Airway Epithelium by Single Cell Analysis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Anthony Oro (Stanford University, USA)
"The Nuclear Option: New Mechanisms of Tumor Evolution and Drug Resistance"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tissue Sensing and Cross-Talk
Discussion Leaders: Kim Jensen (University of Copenhagen, Denmark) and Catherin Niemann (University of Cologne, Germany)
9:00 am - 9:20 am
Diana Bautista (University of California, Berkeley, USA)
"Neuroimmune Interactions in Chronic Itchy Skin"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ellen Lumpkin (Columbia University, USA)
"Exciting Touch: Epithelial-Neural Signaling Mechanisms in Mammals"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Elizabeth Grice (University of Pennsylvania, USA)
"Microbial Roles in Maintenance and Defense of the Skin Barrier"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Swarnabh Bhattacharya (Technion - Israel Institute of Technology, Israel)
"Biomechanical Forces Modulate Epithelial Stem Cell Self-Renewal and De-Differentiation in the Cornea"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Masayuki Amagai (Keio University School of Medicine, Japan)
"Homeostatic Mechanisms of Skin Barrier and Their Disruption in Skin Inflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jessica Moore (Yale University, USA)
"Investigating the Role of Ca2+ in Regulating Epidermal Stem Cell Behaviors via Live Imaging"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Hironobu Fujiwara (RIKEN Center for Biosystems Dynamics Research, Japan)
"A New Model for Orchestrated Hair Follicle Morphogenesis and Stem Cell Induction"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Valerie Horsley (Yale University, USA)
"Fibroblasts and Adipocytes in Skin Repair"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Niches of Organs and Appendages
Discussion Leader: Bruce Morgan (Massachusetts General Hospital / Harvard Medical School, USA)
5:30 pm - 5:40 pm
Yana Kamberov (University of Pennsylvania, USA)
"A Genetic Basis for the Evolution of Adaptive Skin Appendage Traits in Humans"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Maria Alcolea (University of Cambridge, United Kingdom)
"Oesophageal Cell Fate Transitions: Development Meets Homeostasis"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Cheng-Ming Chuong (University of Southern California, USA)
"Bio-Complexity Patterning Principles Revealed by Evo-Devo Studies of Integuments"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Peggy Myung (Yale University, USA)
"Mapping Distinct Molecular and Cellular States of Hair Follicle Dermal Niche Progenitors During Morphogenesis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Stephanie Ellis (The Rockefeller University, USA)
"How Cell Competition Shapes Epidermal Development"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Angela Christiano (Columbia University, USA)
"Hair Follicle and Immune Cell Interactions"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Development and Regeneration
Discussion Leaders: Caterina Missero (CEINGE - Biotecnologie Avanzate / University of Naples Federico II, Italy) and Sophia Lim (Skin Research Institute of Singapore, A*STAR, Singapore)
9:00 am - 9:20 am
Phillip Newmark (Morgridge Institute for Research / University of Wisconsin-Madison, USA)
"Stem Cell-Driven Developmental Transitions in Parasitic Flatworms"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Daniela Grassini (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
"SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Pantelis Rompolas (University of Pennsylvania, USA)
"Live Imaging of the Limbal Niche Reveals Distinct Regulation of Cellular Fate to Support Corneal Regeneration"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Mayumi Ito (New York University, USA)
"SHH Signaling in Hair Follicle Neogenesis"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Bill Lowry (University of California, Los Angeles, USA)
" Exploring a Role for Metabolism in Stem Cell Activation and Transformation"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Raphael Kopan (Cincinnati Children's Hospital Medical Center, USA)
"Growing Old in Ten Days: The Metanephric Progenitor Niche"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Sandra Iden (University of Cologne, Germany)
"Polarity Signaling Ensures Epidermal Homeostasis by Coupling Cellular Mechanics and Genomic Integrity"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Fiona Watt (King's College London, United Kingdom)
"Re-Thinking Heterogeneity of Human Epidermal Stem Cells"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical Advances
Discussion Leader: Slobodan Beronja (Fred Hutchinson Cancer Research Center, USA)
7:30 pm - 7:50 pm
Karuna Ganesh (Memorial Sloan Kettering Cancer Center, USA)
"Targeting Regenerative Plasticity in Metastasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
J. Guy Lyons (Centenary Institute, Australia)
"Grace Under Pressure: Maintaining the Balance Between Proliferation and Delamination in a Stratified Epithelium"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Salvador Aznar Benitah (Institute for Research in Biomedicine (IRB Barcelona), Spain)
"Impact of Our (Fatty) Diet on Metastasis: Why What We Eat Matters"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Gopakumar Changarathil (University of Tsukuba, Japan)
"Wild-Type and SAMP1/8 Mice Show Age Dependent Changes in Distinct Stem Cell Compartments of the Interfollicular Epidermis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Paul Khavari (Stanford University, USA)
"Multiomic Characterization of Epidermal Differentiation"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure