Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Principles of Epidermal and Immune Physiology
Discussion Leader: Salvador Aznar Benitah (Fundació Institut de Recerca Biomèdica (IRB BARCELONA), Spain)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Paul Khavari (Stanford University, United States)
"Genetic Networks and Biomolecular Cues Governing Epidermal Homeostasis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Pierre Coulombe (University of Michigan Medical School, United States)
"Keratinocyte- and Keratin 17- Dependent Neutrophil Recruitment in Inflamed Skin"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells and Homeostasis
Discussion Leader: Pritinder Kaur (Curtin University, Australia)
9:00 am - 9:20 am
Valentina Greco (Yale University, United States)
"Principles of Tissue Dynamics and Function Captured by Live Imaging"
9:20 am - 9:35 am
Discussion
9:35 am - 10:10 am
Fiona Watt (EMBL, Germany)
"Epidermal Differentiation and Dedifferentiation"
10:10 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:30 am
Elaine Fuchs (Howard Hughes Medical Institute, The Rockefeller University, United States)
"Skin Stem Cells: Coping with Stress"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
Sandra Scharaw (Karolinska Institute, Sweden)
"Golgi Organization is a Determinant of Stem Cell Function in the Small Intestine"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Uttkarsh Ayyangar (Institute for Stem Cell Science and Regenerative Medicine, India)
"Epidermal Directed Metabolic Rewiring of Macrophages Promotes Sterile Inflammation in Murine Skin"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Thomas Mortimer (Institute for Research in Biomedicine, Spain)
"Epidermal Circadian Clock Integration and Gating of Brain Signals Guarantees Skin Homeostasis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Sarah Millar (Icahn School of Medicine at Mount Sinai, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Aging and Stress
Discussion Leader: Desmond Tobin (University College Dublin, Ireland)
6:00 pm - 6:20 pm
Emi Nishimura (The University of Tokyo, Japan)
"Stem Cell Fate, Dynamics and Quality Control During Aging"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Vladimir Botchkarev (Boston University, United States)
"Long-Lived Naked Mole-Rats as Unique Model for Human Skin Aging and Disease Resistance"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Ya-chieh Hsu (Harvard University, United States)
"Skin Stem Cells at the Nexus of the Niche, Physiology, and the External Environment"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Kim Jensen (University of Copenhagen, Denmark)
"Dissecting Mechanisms of Intestinal Epithelial Tissue Regeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Epithelial-Environment and Niche Interactions
Discussion Leader: Guiomar Solanas (Institute for Research in Biomedicine, Spain)
9:00 am - 9:20 am
Julie Segre (National Human Genome Research Institute, NIH, United States)
"Human Skin Microbiome: Finding Friends and Foes"
9:20 am - 9:30 am
Discussion
9:30 am - 10:00 am
Coffee Break
10:00 am - 10:20 am
Jessica Strid (Imperial College London, United Kingdom)
"Immune-Surveillance in Healthy Epithelial Tissue and Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Muzlifah Haniffa (Wellcome Sanger Institute, United Kingdom)
"The Developing Human Skin"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Yun Ha Hur (The Rockefeller University, United States)
"A Tissue Injury Repair Pathway Distinct from Host Pathogen Defense"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Daniel Bishop (University of South Australia, Australia)
"A Novel Angiocrine Role for IGF1 in Epidermal Development"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Ram Dasgupta (Genome Institute of Singapore, A*STAR, Singapore)
"Fetal-Like Reprogramming of the Tumor Microenvironment in Liver Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Sarah Millar (Icahn School of Medicine at Mount Sinai, United States)
"KLF4 Maintains Hair Follicle Stem Cell Quiescence"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Rebecca Wagner (German Cancer Centre (DKFZ), Germany)
"SRSF2 Transcriptional Function Maintains Genome Integrity during Cell Division"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Epigenetics
Discussion Leader: Philip Jones (Wellcome Sanger Institute, United Kingdom)
6:00 pm - 6:20 pm
Tudorita (Doina) Tumbar (Cornell University, United States)
"Epidermal Stem and Transit-Amplifying Cell Diversity Through Cell-Intrinsic and Neurovascular Niche Mechanisms"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Anthony Oro (Stanford University, United States)
"The Utility of Chromatin Dynamic Maps for Pathogenesis and Cell-Based Therapy"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
"Regulation of Stem Cell Fate by Nuclear Mechanotransduction"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Elena Ezhkova (Icahn School of Medicine at Mount Sinai, United States)
"Polycomb-Mediated Control of Epidermal Stem Cells in Homeostasis and Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tissue Architecture and Niche Interactions
Discussion Leader: Kathleen Green (Northwestern University, United States)
9:00 am - 9:20 am
Shalev Itzkovitz (Weizmann Institute of Science, Israel)
"Spatial Transcriptomics of the Intestinal Epithelium"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
Michael Rendl (Icahn School of Medicine at Mount Sinai, United States)
"Mesenchymal Control of Hair Follicle Regression"
9:55 am - 10:10 am
Discussion
10:10 am - 10:25 am
Giacomo Donati (University of Torino, Italy, Italy)
"Tissue Memory Relies on Stem Cell Priming in Distal Undamaged Areas"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Maria Kasper (Karolinska Institutet, Sweden)
"Tracing the Emergence of Cell Type Diversity in Skin Development"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Shalini Dimri-Wagh (Technion-Israel Institute of Technology, Israel)
"Repair of Total Stem Cell Loss: A Lesson from the Transparent “Skin” of the Eye"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Clarisse Ganier (King's College London, United Kingdom)
"Fine Mapping of Cell States in Healthy Human Skin across Anatomical Sites and Basal Cell Carcinoma"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Beate Lichtenberger (Medical University of Vienna, Austria)
"CAF Variants Control the Tumor-Immune Microenvironment and Predict Skin Cancer Malignancy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Sung-Jan Lin (National Taiwan University, Taiwan)
"Niche Adipocytes Activate Hair Follicle Stem Cells through Metabolic Priming in Stressed Conditions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Vanessa Lopez-Pajares (Stanford University, United States)
"Glucose Modulates Transcription Factor Dimerization to Enable Tissue Differentiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Tissue Regeneration
Discussion Leader: Bogi Andersen (University of California, Irvine, United States)
6:00 pm - 6:20 pm
Ophir Klein (Cedars-Sinai and University of California, San Francisco, United States)
"Plasticity and Repair in the Oral Cavity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Denis Headon (University of Edinburgh, United Kingdom)
"The Development of Fingerprints and Their Patterns"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Ryan Driskell (Washington State University, United States)
"Epigenetic Regulation of Dermal Fibroblast Differentiation"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Gabriella Rice (University of Pennsylvania, United States)
"Sox9 is Required for Breaking the Symmetry of Stem cell Fate in the Corneal Epithelium"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Carien Niessen (University of Cologne, Germany)
"Cell Shape Regulators in Epidermal Morphogenesis, Regeneration and Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cancer Genetics, Epigenetics and Signalling
Discussion Leader: Srikala Raghavan (A*STAR Skin Research Lab, Singapore)
9:00 am - 9:20 am
Cedric Blanpain (Université Libre de Bruxelles, Belgium)
"Deciphering the Mechanisms of Tumor Initiation at the Single Cell Resolution in Living Mice"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Andrzej Dlugosz (University of Michigan, United States)
"Modulating Cell Fate to Drive Virus-Positive Merkel Cell Carcinoma Development in Mice"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Nuria Lopez-Bigas (IRB Barcelona, Spain)
"Somatic Mutations in Cancer and Normal Tissues"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Michaela Frye (German Cancer Research Center (DKFZ), Germany)
"RNA Modifications as Non-Genetic Drivers of Tumour Heterogeneity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Catherine Lu (New York University, United States)
"Neurotransmitter Signaling Specify Sweat Gland Stem Cell Fate through Sarcolipin-Mediated Intracellular Calcium Regulation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Alexander Marneros (Massachusetts General Hospital/Harvard Medical School, United States)
"Novel regulators of Keratinocyte Differentiation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Emily Scott-Solomon (Harvard University, United States)
"The Root of Hair Loss: Nerves, Immune Cells, and Stem Cells in Stress Induced Alopecia"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Duligengaowa Wuergezhen (RIKEN Center for Biosystems Dynamics Research, Japan)
"Visualization and Functional Characterization of Basement Membrane Dynamics in Developing Mouse Hair Follicles"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Epithelial Therapeutics
Discussion Leader: Terry Lechler (Duke University, United States)
6:00 pm - 6:20 pm
Maria Alcolea (University of Cambridge, United Kingdom)
"Early Tumour Survival is Dictated by Nascent Stromal Niche"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
Angela Christiano (Columbia University, United States)
"Hair Follicles Under Attack: Mechanisms of Autoimmunity in Alopecia Areata"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
Yasmine Belkaid (National Institute of Allergy and Infectious Diseases, NIH, United States)
"Microbiota Control of Skin Immunity and Repair"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
Carolyn Lee (Stanford University, United States)
"Cancer Co-Opts Mast Cell-Derived Histamine to Enable Perineural Invasion"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure