Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Tissue Stem Cell Function
Discussion Leader: Samantha Morris (Washington University in St Louis, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Aaron Zorn (Cincinnati Children's Research Foundation, United States)
"Coordinated Development of Epithelial and Mesenchymal Progenitors in the Embryonic Gut"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Carla Kim (Boston Children's Hospital, United States)
"Regulation of Lung Alveolar Progenitors by Diverse Mesenchymal Cells"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Pantelis Rompolas (University of Pennsylvania, United States)
"Cornea: The Two Faces of Regeneration"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Niche Interactions
Discussion Leader: Anjelica Gonzalez (Yale University, United States)
9:00 am - 9:20 am
Emi Nishimura (The University of Tokyo, Japan)
"Epidermal Stem Cell Competition, Genomic Integrity, and Aging"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
Shuo Han (Stanford University, United States)
"A Neuro-Mesenchymal Axis Regulating Bladder Epithelium Homeostasis and Repair"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Sarah Knox (University of California, San Francisco, United States)
"Mechanisms by which Nerves Regulate Epithelial Organ Development and Regeneration"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Martti Maimets (University of Copenhagen, Denmark)
"Mesenchymal-Epithelial Crosstalk Shapes Regional Differences in the Intestine via Wnt and Shh Signaling"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Ya-chieh Hsu (Harvard University, United States)
"Skin Deep: Stem Cells at the Nexus of the Niche, Physiology, and the External Environment"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Rachel Zwick (University of California, San Francisco (UCSF), United States)
"Epithelial Zonation along the Mammalian Small Intestine Defines Five Discrete Metabolic Domains"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Linda Barlow (University of Colorado Anschutz Medical Campus, United States)
"Single-Cell RNA-Sequencing Analysis of Mouse Circumvallate Papilla Reveals New Progenitors and Taste Lineage Populations"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Sarah Millar (Icahn School of Medicine at Mount Sinai, United States) and Shruti Naik (NYU School of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Models and Technologies
Discussion Leader: Pantelis Rompolas (University of Pennsylvania, United States)
7:30 pm - 7:50 pm
Samantha Morris (Washington University in St Louis, United States)
"New Genomic Technologies to Track and Perturb Cell Identity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Fernando Camargo (Harvard University, United States)
"Epigenetic Mediators of Liver Growth"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Antonio Santos (Stanford, United States)
"A Human Autoimmune Organoid Model of Celiac Disease"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Hans-Willem Snoeck (Columbia University, United States)
"Modeling Interstitial Lung Disease Using Lung Organoids"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Bioengineering of Stem Cells and Niches
Discussion Leader: Nick Barker (Institute of Molecular and Cell Biology, A*STAR, Singapore)
9:00 am - 9:20 am
Anjelica Gonzalez (Yale University, United States)
"Engineering Microenvironmental Niches for Stem Cell Survival and Control"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
Peggy Myung (Yale University, United States)
"Decomposing a Deterministic Path to Mesenchymal Niche Formation by Two Intersecting Morphogen Gradients"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
"Regulation of Stem Cell Fate by Mechanical Force"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Michael Rendl (Icahn School of Medicine at Mount Sinai, United States)
"Dermal Sheath Mechanosignaling Activation of TGF-ß Controls Progenitor Death during Hair Follicle Regression"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Michael Longaker (Stanford University, United States)
"Fibroblasts, Fat and Fibrosis during Wound Repair"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Kara McKinley (Harvard University, United States)
"Identifying the Stem/Progenitor Cells that Regenerate the Uterine Lining After Menstruation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Qiao Zhou (Weill Cornell Medicine, Cornell University, United States)
"SATB2 Controls Colonic Stem Cell Identity and Mucosal Regeneration in Mouse and Human"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of Stem Cell Differentiation
Discussion Leader: Shruti Naik (NYU School of Medicine, United States)
7:30 pm - 7:50 pm
Sarah Millar (Icahn School of Medicine at Mount Sinai, United States)
"Niche-Dependent Roles for KLF4 in the Skin"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Hao Zhu (The University of Texas Southwestern Medical Center, United States)
"Cellular Contributions to Regeneration in Healthy and Diseased Livers"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Xiaomin Bao (Northwestern University, United States)
"Rapid Initiation of Epidermal Progenitor Differentiation via CDK9-Activity Switch Modulated by AFF1 and HEXIM1"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Francesca Spagnoli (King's College London, United Kingdom)
"Exploring the Many Cell Fate Trajectories of Pancreatic Progenitors and their Niches"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cell Plasticity in Development and Cancer
Discussion Leader: Fernando Camargo (Harvard University, United States)
9:00 am - 9:20 am
Nick Barker (Institute of Molecular and Cell Biology, A*STAR, Singapore)
"Deciphering Stem Cell Roles in Driving Onset and Progression of Gastric Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Bartomeu Colom (Wellcome Sanger Institute, United Kingdom)
"Mutant Clones in Normal Epithelium Outcompete and Eliminate Emerging Tumors"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Wenjun Guo (Albert Einstein College of Medicine, United States)
"A Lineage Plasticity Associated Mechanism Protecting Dedifferentiated Cells from Immunosurveillance during Mammary Tumorigenesis"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Cedric Blanpain (Université Libre de Bruxelles, Belgium)
"Mechanisms Regulating Multipotency in Glandular Stem Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Claudia Capdevila Castillo (Columbia University, United States)
"Time-Resolved Fate Mapping Identifies the Upper Crypt Zone as a Developmental Origin of Lgr5+ Intestinal Stem Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Ermanno Malagola (Columbia University, United States)
"Isthmal Stem Cells Sustain Intestinal Homeostasis and Regeneration"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Stromal and Immune Microenvironment
Discussion Leader: Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
7:30 pm - 7:50 pm
Elaine Storm (Genentech, United States)
"Stromal-Derived R-Spondin 3 Is a Key Regulator of Intestinal Regeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Shruti Naik (NYU School of Medicine, United States)
"Eavesdropping on the Conversation Between Immune Cells and Tissue Stem Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Ruth Franklin (Harvard University, United States)
"Macrophage-Epithelial Cell Crosstalk in Tissue Repair"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Shiri Gur-Cohen (School of Medicine, University of California San Diego, United States)
"One Niche to Rule Them All: Lymphatics Instruct Regenerative Potential in Diverse Epithelial Stem Cells"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Niche Dysregulation in Disease and Cancer
Discussion Leader: Ya-chieh Hsu (Harvard University, United States)
9:00 am - 9:30 am
Ilaria Malanchi (The Francis Crick Institute, United Kingdom)
"The Balancing Act of Tissue Regeneration and Cancer"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Jinqiu Lu (Columbia University Medical Center, United States)
"Analysis of a Proximal-Distal Developmental Program during Prostate Organogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Li Xin (University of Washington, United States)
"Ablating Lgr5-Expressing Prostatic Stromal Cells Disrupts Prostate Tissue Homeostasis"
11:00 am - 11:10 am
Discussion
11:10 am - 11:40 am
Mark Krasnow (Howard Hughes Medical Institute / Stanford University School of Medicine, United States)
"Lung Epithelial Stem Cells and Cancer"
11:40 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Kaelyn Sumigray (Yale School of Medicine, United States)
"Fate Specification of a Rare Intestinal Cell Type Implicated in Fluid Secretion"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Generation of Tissue Architecture
Discussion Leader: Cedric Blanpain (Université Libre de Bruxelles, Belgium)
7:30 pm - 8:10 pm
Fiona Watt (King's College London, United Kingdom)
"Tracking Dedifferentiation During Epidermal Wound Healing"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
Leonard Zon (Boston Children's Hospital, United States)
"The Niche and Stem Cell Clonality"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure