Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
New Models and Technologies to Explore Epithelial Stem Cell Niches
Discussion Leader: Ophir Klein (University of California, San Francisco, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
Hailey Cambra (Harvard University, United States)
"Isolated and Collective Clusterin-Associated Responses During Stretch and Injury of the Intestinal Epithelium"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Qiutan Yang (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Mechanobiology in Organoid Crypt Formation"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tracking Epithelial Stem Cell Niche Dynamics During Development and Adult Homeostasis
Discussion Leader: Valerie Horsley (Yale University, United States)
7:30 pm - 7:45 pm
Preetish Kadur Lakshminarasimha Murthy (Duke University School of Medicine, United States)
"Human Distal Lung Maps and Lineage Hierarchies Reveal a Bipotent Progenitor"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Ermanno Malagola (Columbia University, United States)
"Isthmal Stem Cells Sustain Intestinal Homeostasis and Regeneration"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Martti Maimets (University of Copenhagen, Denmark)
"Mesenchymal-Epithelial Crosstalk Shapes Intestinal Regionalization via Wnt and Shh Signalling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Rachel Zwick (University of California, San Francisco (UCSF), United States)
"Epithelial Zonation Along the Mammalian Small Intestine Defines Five Discrete Metabolic Domains"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Maria Fernanda Forni (Yale, United States)
"Metabolic Regulation of Stem Cell Fate in the Skin: How Aging and Caloric Restriction Impact Stemness"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Harnessing Epithelial Niche Signals to Target Human Diseases
Discussion Leader: Carla Kim (Boston Children's Hospital, United States)
9:00 am - 9:15 am
Anne Lynch (Baylor College of Medicine, United States)
"AP-1 as a Transcriptional Regulator of AT2 Cell Reversible Activation During Lung Injury Repair"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Luye An (Cornell University, United States)
"The Role of Cyclooxygenase Signaling in UVB Induced Melanocyte Stem Cell Activation and Migration"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Sonia Sudiwala (University of California San Francisco, United States)
"Long-Term Functional Regeneration of Irradiated Salivary Glands Through Delivery of a Neurogenic Hydrogel"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Wan-Jin Lu (Stanford University, United States)
"Discovering and Engineering the Taste Receptor Stem Cell Niche"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Bartomeu Colom (Wellcome Sanger Institute, United Kingdom)
"Mutant Clones in Normal Epithelium Outcompete and Eliminate Emerging Tumors"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Greta Skrupskelyte (University of Cambridge, United Kingdom)
"Mesenchymal Contribution to Early Oesophageal Tumour Formation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: How to Create and Nurture a Healthy Research Environment
Discussion Leader: Kristyn Carter (Yale University, United States)
1:30 pm - 2:30 pm
Panel Discussion
How to Create and Nurture a Healthy Research Environment
Ophir Klein (University of California, San Francisco, United States)
Carla Kim (Boston Children's Hospital, United States)
Kristyn Carter (Yale University, United States)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
