From the Molecular Composition of Individual Synapses to Neuronal Circuit Function

Synapses are remarkably complex subcellular organelles. They represent key players that mediate the communication between millions of neurons and sculpt information processing in the brain. To achieve such complicated tasks, an intricate molecular machinery is at play, not only to regulate basal synaptic transmission, but also its activity-dependent alterations. The precise regulation of synaptic structure and function is not only important for an appropriate circuit function but, at a larger scale, mediates complex forms of animal behavior.

This GRS aims to understand the molecular, structural and functional mechanisms that underlie synaptic target specificity and its role in functional diversification of neuronal synapses. Moreover, we will examine recent advances on excitatory neuronal network function: from individual receptors, to complex brain circuits underlying behavioral tasks and how this can derail in pathological conditions. The GRS format will allow young scientists to present their work among their peers, while also providing debates for career development in the form of a mentorship panel and round tables with professionals with different research experiences.