Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Extracellular Vesicle Isolation and Vesicle
Characterization (Proteins, RNA Species, Lipids) |
| Discussion Leader: Richard Simpson (La Trobe University, Australia) |
7:40 pm - 8:10 pm | Edwin van der Pol (Academic Medical Center, University of Amsterdam, The Netherlands) "The Pathway to Single Vesicle Detection" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 9:10 pm | Randy Schekman (University of California, Berkeley, USA) "Selectivity and Mechanism of Small RNA Sorting During the Biogenesis of Exosomes" |
9:10 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Extracellular RNA |
| Discussion Leader: David Wong (University of California, Los Angeles, USA) |
9:00 am - 9:20 am | Esther Nolte-'t Hoen (Utrecht University, The Netherlands) "EV-Associated Small RNAs with Potential Regulatory Functions: miRNAs and Beyond" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Nobuyoshi Kosaka (National Cancer Center Research Institute, Japan) "The Role of Secretory miRNAs in Cancer Development" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:40 am | Andrew Hoffman (Tufts University, USA) "Circulating Exosome miRNA in Naturally Occurring Canine Non-Ischemic Heart Diseases" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Leonora Balaj (Massachusetts General Hospital, USA) "Characterization of the Extracellular Content Released from Glioblastoma Cells" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Aleksandar Milosavljevic (Baylor College of Medicine, USA) "Community Resources from the ERCC: The exRNA Portal, the exRNA Atlas and Cloud-Hosted Tools for the Analysis of Extracellular RNA" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Elie Beit-Yannai (Ben-Gurion University of the Negev, Israel) "Exosomes Mediated Signaling Within the Ocular Drainage System" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Reka Haraszti (University of Massachusetts Medical School, USA) "Protein and Lipid Composition Distinguishes Stem Cell EVs from Cancer Cell EVs and Affect Efficiency of EV-Mediated Small RNA Cellular Transfer" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Extracellular Vesicle Biogenesis, Vesicle Cargo
Loading and Targeting RNA |
| Discussion Leader: Stephen Gould (Johns Hopkins University School of Medicine, USA) |
7:30 pm - 7:50 pm | Graca Raposo (Institut Curie, France) "Endosomal Sorting, Exosome Biogenesis Amyloid Formation, Communication: A View from Pigmentation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Pascale Zimmermann (Centre de Recherche en Cancérologie de Marseille, France / Katholieke Universiteit Leuven, Belgium) "Syntenin-Syndecan in the Endosomal and Exosomal Control of Cell Signalling: A Vicious Circle/Target for Cancer Medicine?" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | John Pezacki (University of Ottawa, Canada) "Engineered Molecular Vehicles for Small RNA Delivery" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Harmeet Malhi (Mayo Clinic, USA) "Hepatocytes Release Ceramide-Rich Proinflammatory Extracellular Vesicles in an IRE1Alpha-Dependent Manner" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Extracellular Vesicles in Tissue Injury and
Tissue Repair |
| Discussion Leader: Willem Stoorvogel (Faculty of Veterinary Medicine, Utrecht University, The Netherlands) |
9:00 am - 9:20 am | Stefania Bruno (University of Turin, Italy) "Mesenchymal Stromal Cell-Derived Extracellular Vesicles Facilitate the Repair of Renal Injury" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Juan Sanchez-Esteban (Brown University, USA) "Role of Extracellular Vesicles in Fetal Lung Development" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Olin Liang (Brown University, USA) "Extracellular Vesicles in Pulmonary Vascular Disease: Friend or Foe" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:10 am | David Larocca (ReCyte Therapeutics, USA) "Exosomes from Highly Scalable and Clonally-Derived Embryonic Vascular Progenitor Cells for Therapeutic Angiogenesis" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Bernd Giebel (University of Duisburg-Essen, Germany) "MSC-EVs,
Their Way into Clinic to Treat GvHD" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | George Daaboul (nanoView Diagnostics, USA) "Microarray-Based Direct from Sample Exosome Enumeration, Sizing and Phenotyping" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Maria Brizzi (University of Turin, Italy) "IL-3 Pro-Angiogenic Paracrine Action: Role of Stat5
Trafficking via Endothelial Cell-Derived Extracellular Vesicles" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Role of Extracellular Vesicles in
Inflammation |
| Discussion Leader: Philip Askenase (Yale University, USA) |
7:30 pm - 7:50 pm | Paul Robbins (The Scripps Research Institute, USA) "Immunoregulatory Extracellular Vesicles for Treatment of Autoimmune and Age Related Diseases" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Edit Buzas (Semmelweis University, Hungary) "The Role of Extracellular Vesicles in Inflammation" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Margaret Alexander (University of Utah, USA) "Immune miRNA are Functionally Transferred Between Immune Cells Altering Response to Endotoxin" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Deepak Nagrath (Rice University, USA) "Tumor Microenvironment Derived Exosomes: A Major Player in Regulating Cancer Cell Metabolism" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Non-Mammalian and Plant Extracellular Vesicles |
| Discussion Leader: Meta Kuehn (Duke University Medical Center, USA) |
9:00 am - 9:20 am | Huang-Ge Zhang (University of Louisville, USA) "Edible
Plant Exosomes: Nanoparticles for Therapy and Targeted Delivery of Therapeutic Agents" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Laura De La Canal (National University of Mar del Plata, Argentina) "Biological
Activities of a Vesicle-Associated Extracellular Lectin from Sunflower" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:40 am | Lucia Languino (Thomas Jefferson University, USA) "The AlphaV Integrins Are Upregulated in Prostate Cancer Patient Exosomes and Modulate Exosomal
Levels
of Interferon-Inducible
Proteins" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Amy Buck (University of Edinburgh, United Kingdom) "Vesicle and RNA Secretion by Nematode Parasites: At the Host Interface" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Ciro Tetta (Unicyte AG, Switzerland) "Human Liver Stem Cell (HLSC)-Derived Extracellular Vesicles (EVs) Improve Argininosuccinate Synthase Genetic Deficiency" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Kenneth Witwer (Johns Hopkins University School of Medicine, USA) "Extracellular Vesicles in HIV Production and Latency" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Akira Yokoi (National Cancer Center Research Institute, Japan) "Malignant Extracellular Vesicles Carrying MMP1 mRNA Cause Mesothelial Exfoliation Toward Peritoneal Dissemination in Ovarian Cancer" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Extracellular Vesicles and Thrombosis |
| Discussion Leader: Benjamin Brenner (Rambam Health Care Campus, Technion - Israel Institute of Technology, Israel) |
7:30 pm - 7:50 pm | Mary Collier (University of Leicester, United Kingdom) "Molecular Mechanisms Regulating Tissue Factor Incorporation into Microvesicles" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Nigel Mackman (University of North Carolina at Chapel Hill, USA) "Circulating Procoagulant Microvesicles and Thrombosis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Romaric Lacroix (Aix-Marseille University, France) "Ambivalent Role of Microvesicles in Hemostasis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Linda Rikkert (Academic Medical Center, The Netherlands) "Strategies to Identify Rare Extracellular Vesicles in Human Body Fluids" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Extracellular Vesicles in Neurobiology |
| Discussion Leader: Neha Raukar (Brown University, USA) |
9:00 am - 9:20 am | Fred Hochberg (University of California, San Diego, USA) "Cerebrospinal Fluid Analyses of exRNA" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Richard Kraig (University of Chicago, USA) "Exosomes and Environmental Enrichment-Based Neurotherapeutics" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Michael Chopp (Henry Ford Hospital, USA) "Treatment of Neural Injury
with Exosomes Promotes Neurovascular Remodeling and Functional Recovery" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:10 am | Stacey Gifford (IBM Research, USA) "A Novel Method for Exosome Separation: nanoDLD Chip Technology" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Claudia Verderio (Institute of Neuroscience, National Research Council (CNR), Italy) "Multimodal Microglial Modulation
of Neuronal Functions Through Extracellular Vesicles" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Randolph Corteling (ReNeuron Limited, United Kingdom) "The Development of Neural Stem Cell Exosomes for Clinical Applications" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Shannon Pendergrast (Ymir Genomics LLC, USA) "Enabling Urine Extra-Cellular Biomarker Discovery" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Extracellular Vesicles in Cancer |
| Discussion Leader: Clotilde Thery (Institut Curie, France) |
5:30 pm - 5:50 pm | Peter Kurre (Oregon Health and Science University, USA) "The Role of Extracellular Vesicles in the Hematopoietic
Microenvironment" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Johan Skog (Exosome Diagnostics, USA) "Exosome
Biomarkers, Current State and Future Directions" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Raghu Kalluri (University of Texas MD Anderson Cancer Center, USA) "The Biology and Function of Cancer Exosomes" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Sicheng Wen (Rhode Island Hospital / Brown University, USA) "Mesenchymal Stromal Cell Derived Extracellular Vesicles Rescue Radiation Damage to Murine Marrow Hematopoietic Cells" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |