Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Physio-Pathological Role of Extracellular Vesicles
Discussion Leader: Jan Lotvall (University of Gothenburg, Sweden)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Alissa Weaver (Vanderbilt University School of Medicine, USA)
"Extracellular Vesicles in Cancer Biology"
8:15 pm - 8:35 pm
Discussion
8:35 pm - 9:10 pm
Peter Quesenberry (Brown University / Rhode Island Hospital, USA)
"Tissue Injury and Repair"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biogenesis, Composition and Characterization of Extracellular Vesicles
Discussion Leader: Clotilde Théry (INSERM U932, Institut Curie, France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Willem Stoorvogel (Utrecht University, The Netherlands)
"Triggers for the Release of Extracellular Vesicles from Dendritic Cells"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Xandra Breakefield (Harvard Medical School / Massachusetts General Hospital, USA)
"Monitoring and Facilitating Functional Delivery of Extracellular Vesicle Cargo"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Stephen Gould (Johns Hopkins University School of Medicine, USA)
"Emerging Themes in the Budding of Proteins, Exosomes and Viruses"
11:35 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Dingani Nkosi (Florida State University, USA)
"Epstein-Barr Virus LMP1 Hijacks the Host ESCRT-Dependent Cellular Machineries for Exosomal Excretion"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Juan Tosar (Universidad de la República, Uruguay)
"Glycine tRNA Halves Are Intrinsically Stable Entities Which Can Be Secreted NON-Selectively in EVs and Incorporated in Recipient Cells in a Homotypic Human Cell Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Benedetta Bussolati (Università di Torino, Italy) and Lucia Languino (Thomas Jefferson University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extracellular Vesicles as Delivery Vehicles
Discussion Leader: Anastasia Khvorova (University of Massachusetts Medical School, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
André Görgens (Karolinska Institutet, Sweden)
"Engineered Extracellular Vesicles in Biomedical Applications"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Yong Song Gho (Pohang University of Science and Technology, South Korea)
"Extracllular Vesicle Mimetics"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Steven Jay (University of Maryland, USA)
"Production and Storage Parameters for Therapeutic Extracellular Vesicles"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Juliane Nguyen (University at Buffalo, USA)
"Activity-Composition Analysis of MiRNA-Enriched Exosomes"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modulation of Inflammatory Response by Extracellular Vesicles
Discussion Leader: Andrew Hill (La Trobe University, Australia)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Ciro Tetta (Unicyte AG, Italy)
"HLSC-Derived EV Modulation of Inflammation and Fibrosis"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Adrian Morelli (University of Pittsburgh, USA)
"Extracellular Vesicles and Transplantation"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Edit Buzas (Semmelweis University, Hungary)
"Secretion of Extracellular Vesicle Surface-Associated DNA"
11:35 am - 11:50 am
Discussion
11:50 am - 12:05 pm
John Cadwell (FiberCell Systems Inc., USA)
"Clinical Scale Production of Extracellular Vesicles in a Hollow Fiber Bioreactor"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Elena Batrakova (University of North Carolina at Chapel Hill, USA)
"Development of EV-Based Drug Formulations for Treatment of Neurodegenerative Disorders"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of Extracellular Vesicles in Infectious Diseases
Discussion Leader: Amy Buck (University of Edinburgh, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Vincent Bond (Morehouse School of Medicine, USA)
"HIV-1 Nef Secretion and Extracellular Vesicles"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Esther Nolte (Utrecht University, The Netherlands)
"The Multiple Faces of Naked Virus-Induced Extracellular Vesicles"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Arturo Casadevall (Johns Hopkins Bloomberg School of Public Health, USA)
"Extracellular Vesicles from Cell-Walled Microbes: Fungi and Gram Positive Bacteria"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Neta Regev-Rudzki (Weizmann Institute of Science, Israel)
"Malaria Parasites Regulate Secretion of Exosomes Carrying Distinct Cargo"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Role of Extracellular Vesicles in Cancer Microenvironment and Metastasis
Discussion Leader: Alissa Weaver (Vanderbilt University School of Medicine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Raghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"Exploiting Exosomes for Treatment of Cancer"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Muller Fabbri (University of Hawai'i, USA)
"Extracellular Vesicle MicroRNAs in the Tumor Microenvironment"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Benedetta Bussolati (Università di Torino, Italy)
"Extracellular Vesicles and Cancer Stem Cells"
11:35 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Shiv Ram Krishn (Thomas Jefferson University, USA)
"Prostate Cancer Sheds avĪ²3 Integrin In Vivo Through Exosomes that Are Transferred to Other Cells in the Tumor Microenvironment"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Cristiana Spinelli (McGill University, Canada)
"Molecular Subtypes and Differentiation of Glioma Stem Cells as Determinanants of Extracellular Vesicle Profiles and Endothelial Cell Stimulating Activities"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Diagnostic and Therapeutic Applications of Extracellular Vesicles
Discussion Leader: Raghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Bernd Giebel (University of Duisburg-Essen, Germany)
"Dissection of the Heterogeneity of Extracellular Vesicles in Supernatants of Mesenchymal Stem/Stromal Cells"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Alain Brisson (University of Bordeaux, France)
"Imaging and Quantification of Extracellular Vesicles"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Randolph Corteling (ReNeuron Limited, United Kingdom)
"Production of Functionally Bioactive Extracellular Vesicles from Immortalized Human Neural Stem Cells"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Dana Larocca (AgeX Therapeutics, Inc, USA)
"A Highly Diverse and Scalable Progenitor Stem Cell Bank for Identifying and Producing Therapeutic Extracellular Vesicles"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
The Role of Extracellular Vesicles in Neurobiology
Discussion Leader: Xandra Breakefield (Harvard Medical School / Massachusetts General Hospital, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Hollis Cline (The Scripps Research Institute, USA)
"Exosome Signaling in Brain Development"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Andrew Hill (La Trobe University, Australia)
"The Role of Extracellular Vesicles in Neurodegenerative Diseases"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Anastasia Khvorova (University of Massachusetts Medical School, USA)
"Defining Exosome Properties for Neuronal Trafficking"
11:35 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Travis Thomson (University of Massachusetts Medical School, USA)
"RNA Transfer Across Synaptic Boutons Using Extracellular Vesicles and a Viral-Like Mechanism"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
The Role of Extracellular Vesicles in Stem Cell Biology and Potential Clinical Applications
Discussion Leader: Bernd Giebel (University of Duisburg-Essen, Germany)
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 5:50 pm
Ann-Sophie Walravens (Capricor Therapeutics, USA)
"Extracellular Vesicles from Potent and Non-Potent Cardiosphere-Derived Cells and from Mesenchymal Stem Cells Elicit Different Immunomodulatory Properties"
5:50 pm - 5:55 pm
Discussion
5:55 pm - 6:10 pm
Dandan Zhu (The Ritchie Centre, Hudson Institute of Medical Research / Monash University, Australia)
"Human Amnion Cell-Derived Extracellular Vesicles in the Treatment of Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:45 pm
Bas van Balkom (University Medical Center Utrecht, The Netherlands)
"Extracellular Vescicles and Acute Kidney Injury"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:15 pm
General Discussion
7:15 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure