Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Starting Early Embryogenesis
Discussion Leader: Gary Wessel (Brown University, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:20 pm
Carmen Williams (National Institute of Environmental Health Sciences, NIH, USA)
"Developmentally Programmed Tankyrase Activity Licenses Progression of Embryonic Genome Activation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Nicolas Plachta (Institute of Molecular and Cell Biology, A*STAR, Singapore)
"Imaging How Cells Choose Their Fate, Shape and Position in the Living Embryo"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Amy Ralston (Michigan State University, USA)
"The Embryonic Origins of Pluripotency"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Sperm-Egg Fusion
Discussion Leader: Patricia Cuasnicu (Instituto de Biología y Medicina Experimental (IBYME), CONICET, Argentina)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Jurrien Dean (National Institutes of Health, USA)
"Stem Cell Maintenance, piRNAs and Monospermic Fertilization"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Mark Johnson (Brown University, USA)
"Gamete Fusion Mechanisms"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Amber Krauchunas (Rutgers University, USA)
"The Molecular Underpinnings of the C. elegans Fertilization Synapse"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Andrea Pauli (Research Institute of Molecular Pathology (IMP), Austria)
"Species-Specificity of Fertilization"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Pablo Bermejo-Álvarez (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Spain)
"TMEM95 Is Required for Sperm-Egg Membrane Fusion"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Celia Santi (Washington University in St. Louis, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling During Gamete Maturation and Fertilization
Discussion Leader: Masahito Ikawa (Osaka University, Japan)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Alberto Darszon (Universidad Nacional de Mexico, Mexico)
"CatSper Regulation by PKA and the Importance of Acrosomal pH for the Acrosome Reaction"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Khaled Machaca (Weill Cornell Medicine-Qatar, Qatar)
"Dissecting Non-Genomic Progesterone-Dependent Signaling Pathways that Induce Frog Oocyte Maturation"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Long Miao (Institute of Biophysics, Chinese Academy of Sciences, China)
"The Plasma Membrane Compartmentalization of Na/K ATPase During Sperm Activation Modulates Sperm Migration and Fertility in the Nematode C. elegans "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Anne Carlson (University of Pittsburgh, USA)
"A Chloride Channel Provides the First Defense Against Abnormal Fertilization in Xenopus laevis "
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Evolution of Reproductive Strategies and Sperm Competition
Discussion Leader: Gillian Stanfield (University of Utah, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Brett Nixon (The University of Newcastle, Australia)
"The Evolutionary Significance of Post-Testicular Sperm Maturation: Insights from Birds, Reptiles and Mammals"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Diane Shakes (College of William and Mary, USA)
"How Variations in X Chromosome Segregation Support Skewed Sex Ratios in the Nematode Auanema rhodensis "
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Stuart Wigby (University of Oxford, United Kingdom)
"Ejaculate Composition: The Roles of Rivals and Ageing"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Mariana Wolfner (Cornell University, USA)
"Egg Activation Mechanisms in Drosophila : Uncovering 'Deep Homology'"
11:30 am - 11:40 am
Discussion
11:40 am - 11:45 am
Introduction by Discussion Leader
11:45 am - 11:55 am
Jay Baltz (Ottawa Hospital Research Institute, Canada)
"Metalloproteinase Activity Is Required for Release of Oocyte-Zonapellucida Adhesion"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ethan Greenblatt (Carnegie Institution for Science, USA)
"Insights into Reproductive and Intellectual Disorders in Quiescent Oocytes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Miguel (Mao) Leung (University of Oxford, United Kingdom)
"Imaging the Structural Organization of Mammalian Spermatozoa from the Cellular to the Supramolecular Level"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of the Reproductive Tract During Gametogenesis and Fertilization
Discussion Leader: Andrew Singson (Rutgers University, USA)
7:30 pm - 7:50 pm
Sue Hammoud (University of Michigan, USA)
"Characterizing Chromatin and Transcriptional States of Germ Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Barry Hinton (University of Virginia, USA)
"Intrinsic and Extrinsic Forces Are Major Drivers of Wolffian Duct Morphogenesis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Patricia Deleon (University of Delaware, USA)
"Extracellular Vesicles in the Female Tract: Interaction of Exosomes with Sperm"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Francesca Duncan (Northwestern University, USA)
"A Changing Matrix: Ovarian Hyaluronan, Inflammation and Reproductive Aging"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Meiosis During Sperm and Egg Development
Discussion Leader: Laurinda Jaffe (University of Connecticut, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Abby Dernburg (University of California, Berkeley, USA)
"Crossover Control During Meiosis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Francesca Cole (University of Texas MD Anderson Cancer Center, USA)
"How Meiosis Ensures Accurate Chromosome Segregation into Sperm"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Evelyn Houliston (CNRS, France)
"Oocyte Meiotic Progression in the Jellyfish Model Clytia hemisphaerica "
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Christophe Arnoult (Institute for Advanced Biosciences, Université Grenoble Alpes / CNRS, France)
"PATL Is Required for Oocyte Meiosis/Maturation and Early Development"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Mayu Inaba (University of Connecticut Health Center, USA)
"Niche Cells Spatially Restrict Stem-Cell Self-Renewal Signalling via Receptor-Ligand Degradation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Sperm Motility and Finding the Egg
Discussion Leader: Pablo Visconti (University of Massachusetts Amherst, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Daniela Nicastro (University of Texas Southwestern Medical Center, USA)
"Cryo-Electron Microscopy Studies Provide New Insights into the Structure and Motility of Sperm Flagella"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Jean-Ju Chung (Yale School of Medicine, USA)
"Sperm Ca2+ Signaling Nanodomains in Motility Regulation: CatSper Channels and Beyond"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Dario Krapf (Institute of Molecular and Cell Biology of Rosario (IBR-CONICET), Argentina)
"New Insights into Molecular Pathways Leading to Human Sperm Capacitation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Selected Poster Presentations
Short talks selected from the posters.
Discussion Leader: Celia Santi (Washington University in St. Louis, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
Nicolas Brukman (Technion - Israel Institute of Technology, Israel)
"Characterization of Candidate Fusexin-Like Gamete Fusion Proteins on Mammalian Eggs"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Victoria Deneke (Research Institute of Molecular Pathology (IMP), Austria)
"Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Melanie Balbach (Weill Cornell Medicine, USA)
"Change in Energy Metabolism During Sperm Capacitation in Mouse Strains with Different Fecundity"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Maximilian Lyon (Washington University in St. Louis, USA)
"Novel SLO3 Inhibitors as Blockers of Human Sperm Capacitation"
10:05 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 10:50 am
Introduction by Discussion Leader
10:50 am - 11:00 am
Corie Owen (UConn Health, USA)
"Intercellular Communication Between the Luteinizing Hormone Receptor and the NPR2 Guanylyl Cyclase in Mouse Ovarian Follicles"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
Timothy Weil (University of Cambridge, United Kingdom)
"Egg Activation in Drosophila "
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Damien Wilburn (University of Washington, USA)
"Indirect Sexual Selection Drives Rapid Evolution of an Intrinsically Disordered Sperm Protein"
11:30 am - 11:35 am
Discussion
11:35 am - 11:40 am
Introduction by Discussion Leader
11:40 am - 12:20 pm
Kay Elder (Bourn Hall Clinic, United Kingdom)
"Historical Perspectives: Human Preimplantation Embryos, 1969-2019"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Assisted Reproductive Technologies: New Approaches and Ethical Concerns
Discussion Leader: Alexander Travis (Cornell University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Christopher Barratt (University of Dundee, United Kingdom)
"Bringing Andrology into the 21st Century: High Throughput Screening for Motile Human Sperm"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Werner Neuhausser (Harvard University, USA)
"ART in the Era of Single Cell Genomics"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Sigal Klipstein (InVia Fertility Specialists, USA)
"The Myth of the Designer Child: Parental Decision Making in an Era of Expanding Reproductive Options"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure