SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Lectures |
7:30 pm - 7:40 pm | Discussion Leaders: David Ornitz (Washington University, USA) & Bradley Olwin (University of Colorado, Boulder, USA)
Meeting intro, etc. |
7:40 pm - 8:25 pm | Gail Martin (University of California San Francisco, USA)
"FGF signaling in organogenesis: how Sprouty genes help get it right" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Joseph Schlessinger (Yale University Medical School, USA)
"Cell signaling by receptor tyrosine kinases: from bench to bedside" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Wine and Cheese Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Carbohydrate Regulation of FGF Function |
| Discussion Leader: Alan Rapraeger (University of Wisconsin-Madison, USA) |
9:00 am - 9:20 am | Alan Rapraeger (University of Wisconsin-Madison, USA)
"Diversity in Heparan Sulfate as a Regulator of FGF Signaling" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | David Fernig (University of Liverpool, UK)
"Regulation of FGFR signalling by sugars and ligand concentration" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:20 am - 10:40 am | Moosa Mohammadi (New York University, USA)
"Structural basis for FGF receptor activation: implications in development and disease" |
10:40 am - 10:50 am | Discussion |
10:50 am - 11:10 am | Victor Nurcombe (IMCB Singapore)
"Heparan sulfates can couple particular FGF ligand-receptor pairs to drive phenotypic outcomes" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Jeremy Turnbull (University of Liverpool, UK)
"Extracellular modulators enhance the versatility of FGF signaling: roles of heparan sulfate, anosmin and neuropilin" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Lijuan Zhang (Washington University School of Medicine, USA)
"Glycosaminoglycan activators and inhibitors of FGF/FGFR signaling" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Anton Wellstein (Georgetown University, USA)
"The biology and pathology of FGF-binding proteins" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Heart, Lung and Vasculature |
| Discussion Leader: Gail Martin (University of California, San Francisco, USA) |
7:30 pm - 7:50 pm | Anne Moon (University of Utah, USA)
"Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kory Lavine (Washington University School of Medicine, USA)
"FGF signaling in cardiac development and disease" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Saverio Bellusci (University of Southern California, USA)
"Mesenchymal FGF signaling and smooth muscle cell differentiation in the mouse embryonic lung" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Lena Claesson-Welsh (Uppsala University, Sweden)
"FGFR-1 in vascular development" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Physiology, Genetics and Epithelial Biology |
| Discussion Leader: Nobu Itoh (Kyoto University, Japan) |
9:00 am - 9:20 am | Alexei Kharitonenkov (Eli Lilly and Company, USA)
"FGF-21 in diabetes" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Wallace McKeehan (Institute of Biosciences & Technology, USA)
"FGF signaling in adult metabolic homeostasis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Andrew Wilkie (Oxford University, UK)
"Mutation and allelic imbalance in human FGFRs" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Rachael Brake (Amgen Inc., USA)
"KGF to Kepivance - recent pre-clinical studies of Kepivance in drug combinations" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Richard Grose (Bart's and the London School of Medicine, QMUL)
"Fibroblast growth factor receptor 2b in skin development and carcinogenesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Sabine Werner (Institute of Cell Biology, ETH Zurich)
"Fibroblast growth factors in skin morphogenesis, homeostasis and repair" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Patterning and FGFs |
| Discussion Leader: Claudio Basilico (New York University Medical School, USA) |
7:30 pm - 7:50 pm | Nobu Itoh (Kyoto University, Japan) "FGF signaling in hematopoietic development" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Matthew Hoffman (NIDCR, National Institutes of Health, USA)
"FGF regulation of submandibular gland branching morphogenesis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Angela Stathopoulos (California Institute of Technology, USA) "Different functions of Pyramus and Thisbe FGF ligands in Drosophila" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Zipora Yablonka-Reuveni (University of Washington School of Medicine, USA) "Classic and novel FGFR4 forms are expressed during myogenesis" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Bill LaRochelle (CuraGen Inc., USA) "Velafermin: A unique regenerative FGF for the treatment of chemical- and radiation-induced tissue injury" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulating the FGF Signal and Cancer |
| Discussion Leader: Sabine Werner (Institute of Cell Biology, ETH Zurich) |
9:00 am - 9:20 am | Enrique Amaya (University of Cambridge, UK)
"FGF signal interpretation during early vertebrate development" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Dina Ron (Technion-Israel Institute of Technology, Israel)
"The multifaceted nature of the mammalian Sef gene" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:45 am | Michal Stachowiak (Suny at Buffalo, USA)
"Integrative nuclear FGFR1 signaling (INFS) as a part of 'Feed-Forward-And Gate' signaling module that controls cell growth and differentiation" |
10:45 am - 10:55 am | Discussion |
10:55 am - 11:10 am | Sjur Olnes (University of Oslo, Norway)
"Translocation of exogenous FGF to cytosol/nucleus and intracellular actions of the growth factors" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Fen Wang (Texas A&M Health Science Center, USA) "Epithelial cell type 2 fibroblast growth factor receptor (FGFR2) is essential for normal prostatic development and response to androgen" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Claudio Basilico (New York University Medical Center, USA)
"Differential cell responses to FGF signaling" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Haijun Sun (Imclone Systems Inc., USA) "Neutralizing antibodies to FGF receptors 1 and 3 inhibit tumor growth in mouse xenograft studies" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | FGF Function in the Central Nervous System |
| Discussion Leader: Juha Partanen (University of Helsinki, Finland) |
7:30 pm - 7:50 pm | Juha Partanen (University of Helsinki, Finland)
"Genetic analysis of FGF signalling pathways regulating development of the midbrain and anterior hindbrain" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Alexandra Joyner (New York University Medical Center, USA)
"Temporal requirement for the isthmic organizer molecule Fgf8 during mouse development" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Anne Calof (University of California, Irvine, USA) "Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Jean Hebert (Albert Einstein College of Medicine, USA) "FGF signaling is required for several patterning steps during cerebrum development" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | D. Cornelison (University of Missouri, Columbia)
"FGF signaling through syndecan-4 in primary muscle satellite cells" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Skeletal Development |
| Discussion Leader: Gillian Morriss-Kay (Oxford, UK) |
9:00 am - 9:20 am | Gillian Morriss-Kay (Oxford University, UK)
"FGF-FGFR signaling in craniofacial development: insights from mutant mice" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Marja Hurley (University of Connecticut Health Center, USA)
"Role of Exported and Intracellular FGF-2 Isoforms in Bone" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:45 am | Kai Yu (Washington University School of Medicine, USA) "Fgfr functional redundancy in skeletal development" |
10:45 am - 10:55 am | Discussion |
10:55 am - 11:10 am | Janet Henderson (McGill University, Quebec) "FGFR3 signaling in the adult skeleton" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | William Horton (University of Oregon Heath Science campus and Shriners Hospital for Children, USA) "Modulation of Fgfr3 signals" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Anton Bennett (Yale University, USA) "Regulation of FGF signaling by phosphatases in skeletal muscle" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Mark Lewandoski (National Cancer Institute, USA)
"Unique and redundant roles of FGF ligands in the emerging primary mesoderm" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Novel Mechanisms for FGF Function in Development and Disease |
| Discussion Leader: William Horton (University of Oregon Heath Science campus and Shriners Hospital, USA) |
7:30 pm - 7:50 pm | Brad Olwin (University of Colorado, USA) "Unique roles for FGFR-1 and FGFR-4 in skeletal muscle stem cells and muscle regeneration" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Gary Schoenwolf (University of Utah, USA) "Endodermal signaling patterns the mesoderm and ectoderm during vertebrate gastrulation/neurulation" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Olivier Pourquie (Stowers Institute for Medical Research, USA) "FGF signaling in somitogenesis" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |