SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | FGF SIGNALING: AN OVERVIEW |
| Discussion Leader: Claudio Basilico (New York University, USA) |
7:40 pm - 8:20 pm | Moosa Mohammadi (New York University, USA)
"Structural basis for FGF receptor activation in human diseases" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | David Ornitz (Washington University, USA)
"FGF-WNT gene regulatory network regulates lung mesenchyme development" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FGF FUNCTION IN ORGANOGENESIS |
| Discussion Leader: Gail Martin (University of California, San Francisco, USA) |
9:00 am - 9:20 am | Matthew Hoffman (NIH, Bethesda, USA)
"Heparan sulfate regulation of FGF10-mediated submandibular gland branching morphogenesis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Tom Kornberg (University of California, San Francisco, USA)
"The roles of Drosophila FGF in organ induction and mitogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 10:50 am | Angelike Stathopoulos (CalTech, USA)
"The coordination of cell movements during Drosophila gastrulation: the role of FGF signaling" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Suzi Mansour (University of Utah, USA)
"FGF signaling in inner ear development" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Nobuyuki Itoh (University of Kyoto)
"The role of FGF16 in heart development" |
11.50 am -12:00 pm | Discussion |
12:00 pm - 12:10 pm | Mark Lewandoski (National Cancer Institute, USA)
"The vertebrate limb is patterned by BMP-mediated modulation of FGF signals via Sprouty expression" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Beat Trueb (University of Bern, Switzerland)
"Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | DEVELOPMENT OF THE NERVOUS SYSTEM |
| Discussion Leader: Ivor Mason |
5:30 pm - 5:50 pm | Ann Calof (University of California, Irvine, USA)
"FGFs, neurogenesis in the primary olfactory system, and the origin of GnRH-expressing neurons in the mouse" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Albert Basson (King's College London, UK)
"FGF signalling in cerebellar morphogenesis" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Hisashi Umemori (University of Michigan, USA)
"Specific Synapse Formation by FGFs" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Jean Hebert (Albert Einstein College of Medicine, USA)
"FGF signaling acts as an organizer for the telencephalon" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
9:15 pm | Poster Session |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SKELETAL BIOLOGY |
| Discussion Leader: David Ornitz (Washington University, USA) |
9:00 am - 9:20 am | William Horton (University of Oregon Heath Science campus and Shriners Hospital for Children, USA)
"Strategies to counter excessive FGFR3 signals" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Victor Nurcombe (Institute of Molecular and Cell Biology, Singapore)
"Regulation of FGF/BMP loops by heparans during osteogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Irene Hung (University of Utah, USA)
"FGF Signaling in Skeletal Development" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Janet Henderson (McGill University, Canada)
"FGF18 to promote bone regeneration and repair" |
11:20 am - 11:30 am | Discussion |
11.30 am - 11:50 am | Claudio Basilico (New York University, USA)
"Key events determine the growth-inhibitory response of chondrocytes to FGF signaling" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Christoph Ladel (Merck Serono Research, Italy)
"FGF18 as therapeutic for osteoarthritis: Efficacy of rhFGF18 in preclinical models of osteoarthritis" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Tonia Vincent (Kenedy Institute, London)
"FGF2 is an intrinsic chondroprotective agent, which suppresses the proteinase ADAMTS5, and delays cartilage degradation in osteoarthritis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | NERVOUS SYSTEM FUNCTION AND REPAIR |
| Discussion Leader: Klaus Unsicker (University of Heidelberg, Germany) |
5:30 pm - 5:50 pm | Oliver von Bohlen und Halbach (University of Heidelberg, Germany)
"FGF-2 in an animal model of depression" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Marco Riva (University of Milan, Italy)
"FGF2 regulation in drug abuse and stress response" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Claudia Grothe (University of Hannover, Germany)
"Regenerative potential of endogenous and cell-based applied FGF-2 in two animal models, Parkinson's disease and peripheral nerve regeneration" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Mitchell Goldfarb (City University, New York, USA)
"FHF control of sodium channel physiology and neuronal function: insights from mutant mice" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
9:15 pm | Poster Session |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | TUMORIGENESIS |
| Discussion Leader: Victor Nurcombe (Institute of Molecular and Cell Biology, Singapore) |
9:00 am - 9:20 am | François Radvanyi (Institut Curie, France)
"Role of FGFR3 in tumours" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Richard Grose (Institute of Cancer, UK)
"Epithelial FGFR2: oncogene or tumour suppressor?" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Michael Seckl (Imperial College, UK)
"FGF-2 triggers a novel signaling machine enhancing translation of anti-apoptotic proteins and driving chemoresistance in lung cancer" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Dina Ron (Technion, Israel)
"Sef regulation in normal and cancer cells" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Marco Presta (University of Brescia, Italy)
"FGF2 as a damage-associated molecular pattern (DAMP) proangiogenic cytokine" |
11.50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Igor Prudovsky (Maine Medical Centre, USA)
"Repression of CBF1-mediated Notch signaling results in FGF1 export and cell transformation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Soo Hyun Kim (University College, UK)
"Anosmin-1 mediates crosstalk between TGF-beta 1 and FGFR1 signal pathways in development and tumourigenesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | HOMEOSTASIS |
| Discussion Leader: Sabine Werner |
5:30 pm - 5:50 pm | Toru Imamura (National Institute of Advanced Industrial Science and Technology)
"BetaKlotho is required for FGF21 signaling" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Itaru Urakawa (Kirin Brewery Co, Japan)
"Role of FGF23 in phosphate homeostasis" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Makoto Kuro-o (University of Texas, USA)
"Interaction between the Klotho and FGF19 family members" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Alexei Kharitonenkov (Lilly Research Laboratories, USA)
"Metabolic actions of FGF21" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
9:15 pm | Poster Session |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STEM CELLS, REGENERATION AND TISSUE REPAIR |
| Discussion Leader: Janet Henderson (McGill University, Canada) |
9:00 am - 9:20 am | Sabine Werner (Eidgenössische Technische Hochschule Zurich, Switzerland)
"Fibroblast growth factors in epithelial morphogenesis and tissue repair" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Gerald de Haan (University Medical Center Groningen, Netherlands)
"Culturing hematopoietic stem cells with FGFs" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Bradley Olwin (University of Colorado, USA)
"A critical role for FGFR4 in regeneration of skeletal muscle" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Robert Friesel (Maine Medical Centre, USA)
"Overexpression of Spry1 in Chondrocytes Results in Attenuated FGFR Ubiquitinylation and Sustains ERK activation Results in Chondrodysplasia" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | John Whitelock (University of New South Wales, Australia)
"HS on perlecan determines the fate of chondorcytes via its interactions with FGFs" |
11.45 am - 11:53 am | Discussion |
11:53 am - 12:03 pm | Shinya Murakami (Osaka University, Japan)
"Trial in Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2:Randomized Controlled Phase II Clinical Trial8Randomized Controlled Phase II Clinical Trial" |
12:03 pm - 12:08 pm | Discussion |
12:08 pm - 12:22 pm | Saverio Bellusci (Children's Hospital Los Angeles, USA)
"Induction of FGF10 in the ileal crypt epithelium after massive small bowel suggests a role for FGF10 in gut adaptation" |
12:22 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | REGULATING THE FGF SIGNAL |
| Discussion Leader: Moosa Mohammedi (New York University, USA) |
5:30 pm - 5:50 pm | Jeremy Turnbull (University of Liverpool, UK)
"Decoding the chemical biology of heparan sulfate: an ES-MS sequencing strategy reveals specific modulation of FGF signalling" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:10 pm | Helen Makarenkova (The Neurosciences Institute, USA)
"A molecular basis for FGF gradient formation and regulation of branching morphogenesis" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:25 pm | Ugo Cavallaro (IFOM-IEO, Italy)
"The NCAM/FGFR cross talk: a novel paradigm in FGFR signalling" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Fen Wang (Texas A&M, USA)
"FGF signaling in prostate development and tumorigenesis" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Antoni Wiedlocha (Institute for Cancer Research, Oslo, Norway)
"Role of p38 MAPK in translocation of FGF-1 into cells" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
9:15 pm | Poster Session |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |