SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote presentations: The FGF family |
| Discussion Leaders: Sabine Werner (ETH Zurich, Switzerland) and Moosa Mohammadi (New York University School of Medicine, New York, USA) |
7:40 pm - 8.00 pm | Judith Abraham (Novartis Institutes for BioMedical Research, Emeryville, USA)
"Key events of the 'early days' of FGF research" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Joseph Schlessinger (Yale University, New Haven, USA)
"Regulatory mechanisms underlying FGF receptors and other receptor tyrosine kinases" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Steven Kliewer (University of Texas, Dallas, USA)
"Endocrine FGFs: From feast to famine" |
9:10 pm - 9:20 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Biochemistry of FGFs, FGF signaling |
| Discussion Leader: Jeremy Turnbull (University of Liverpool, UK) |
9:00 am - 9:20 am | Jeremy Turnbull (University of Liverpool, UK)
"Extracellular regulation of FGF signalling - Roles of anosmin and heparan sulfates" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | David Fernig (University of Liverpool, UK)
"Tracking of individual FGFs on living cells reveals novel modes of molecular diffusion at the cell surface and of oligomerisation of signalling complexes" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Walter Nickel (University of Heidelberg, Germany)
"Molecular analysis of the unconventional secretory pathway of FGF2" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | John Heath (University of Birmingham, UK)
"Architecture and dynamics of the FGF signaling pathway(s)" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Akira Imamoto (University of Chicago, USA)
"Probing protein-protein interactions for an FGFR1/2 signaling feedforward loop" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Andrew Beenken (New York University, School of Medicine, USA)
"Structural basis for FGF-FGFR binding specificity and promiscuity" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Arno Muller (University of Dundee, UK)
"The Drosophila nesthocker mutation reveals a novel link between O-GlcNAcylation and Fibroblast Growth Factor signalling" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Interactions of FGFs with other signaling pathways |
| Discussion Leader: Gail Martin (University of California, San Francisco, USA) |
7:30 pm - 7:50 pm | Claudio Basilico (New York University School of Medicine, New York, USA)
"FGF induces Sox2 to promote osteoblast self-renewal" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Hichem Miraoui (INSERM U606, Paris, France)
"Increased EGF and PDGF-alpha receptor signaling by mutant FGF receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Toru Imamura (National Institute of Advanced Industrial Science and Technology, Tsukaba, Japan)
"Association between FGF18 signaling and resting phase of hair growth" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Irma Thesleff (University of Helsinki, Finland)
"Integration of FGF and other signal pathways during tooth development" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | David Ornitz (Washington University, St. Louis, USA)
"Intracellular FGFs: conserved structure, unique function" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FGFs in Development |
| Discussion Leader: David Ornitz (Washington University, St. Louis, USA) |
9:00 am - 9:20 am | Olivier Pourquié (Institute of Genetics and Molecular and Cellular Biology, Strasbourg, France)
"Role of FGF signaling in patterning the vertebrate embryonic axis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Joseph Yost (University of Utah, Salt Lake City, USA)
"FGF signaling pathways and HSPG fine structures regulate cilia functions in development" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Deborah Yelon (University of California, San Diego, USA)
"Effects of FGF signaling on the zebrafish heart fields" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:10 am | Judith Neugebauer (University of Utah, Salt Lake City, USA)
"FGF signaling controls brain laterality in early embryo development" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Angela Stathopoulos (Caltech, Pasadena, USA)
"Mesoderm migration in Drosophila is a multi-step process requiring two FGF ligands" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Gail Martin (University of California, San Francisco, USA)
"Regulation of oriented cell division by FGF signaling in airway morphogenesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Sung-Ho Huh (Washington University, St. Louis, USA)
"FGF9 subfamily regulates organ of Corti development" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Albert Basson (King's College, London, UK)
"Sprouty genes function as negative regulators of the FGF signalling pathway during cerebellar development" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FGFs in the Nervous System |
| Discussion Leader: Klaus Unsicker (University of Freiburg, Germany) |
7:30 pm - 7:50 pm | Steve Wilson (University College London, UK)
"A role for FGF signalling in the establishment of brain asymmetry" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | James Li (University of Connecticut, Farmington, USA)
"Interactions among different FGF8 splice forms in the control of midbrain-hindbrain development" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Juha Partanen (University of Helsinki, Finland)
"FGF signalling and neuronal development in the embryonic midbrain" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Klaus Unsicker (University of Freiburg, Germany)
"Regulation of astroglial functions and neural progenitor cells by FGF2" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Mohammad Hajihosseini (School of Biological Sciences, Norwich, UK)
"FGF10 expressing tanycytes in the adult hypothalamus resemble neural stem cells and generate both neurons and glia in vivo" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Endocrine FGFs |
| Discussion Leader: Steven Kliewer (University of Texas, Dallas, USA) |
9:00 am - 9:20 am | Wallace McKeehan (Texas A&M Health Science Center, Houston)
"Beta-Klotho directs FGFR4 and FGFR1 signaling to metabolism and tumor suppression" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Nobuyuki Itoh (Kyoto University, Japan)
"Roles of FGF21 signaling in energy metabolism" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:40 am | Yang Li (Amgen Inc., South San Francisco, USA)
"FGF19 activates different FGFRs to control distinct biological responses" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Beate Lanske (Harvard Medical School, Boston, USA)
"FGF23: an endocrine hormone derived from bone" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Makoto Kuro-O (University of Texas, Dallas, USA)
"Endocrine FGFs and Klothos" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Yo-Ishi Nabeshima (Kyoto University, Japan) |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Barbara Haenzi (Friedrich Miescher Laboratories, Basel, Switzerland)
"MEMO, a novel downstream effector of the FGFR pathway" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FGFs in Genetic / Developmental Disease |
| Discussion Leader: Bradley Olwin (University of Colorado Boulder, USA) |
7:30 pm - 7:50 pm | Marja Hurley (University of Connecticut, Farmington, USA)
"Nuclear FGF2 isoforms are novel regulators of phosphate homeostasis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Suzi Mansour (University of Utah, Salt Lake City, USA)
"Genetic rescue of hearing loss in a mouse model of Muenke syndrome (FGFR3 P244R)" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Richard Grose (Institute of Cancer, Barts and The London School of Medicine and Dentistry, London, UK)
"Insights from the FGF22 knockout mouse" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Andrew Wilkie (University of Oxford, UK)
"Selfish FGF receptor mutations and spermatogenesis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Nelly Pitteloud (Massachusetts General Hospital, Boston, USA)
"Role of FGF signaling in the neuroendocrine control of reproduction" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FGFs in Tissue Repair, Regeneration and Remodelling |
| Discussion Leader: Andrew Wilkie (University of Oxford, UK) |
9:00 am - 9:20 am | Saverio Bellusci (University of Southern California, Los Angeles, USA)
"Expected and unexpected roles for fibroblast growth factor 10 in development and repair" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Michael Simons (Yale University, New Haven, USA)
"FGF signaling in the endothelium" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | George Cotsarelis (University of Pennsylvania, Philadelphia, USA)
"FGFs in hair follicle neogenesis following wounding" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:10 am | Ariel Arthur (Glasgow Biomedical Research Center, Glasgow, UK)
"The role of fibroblast growth factor-9 in chronically demyelinated multiple sclerosis lesions" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Bradley Olwin (University of Colorado, Boulder, USA)
"A requirement for FGF Receptor 1 in skeletal muscle stem cell self-renewal and muscle regeneration" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Janet Bodmer (University of Cincinnati, USA)
"The alpha isoform of PKC is necessary for low molecular weight fibroblast growth factor 2-mediated cardioprotection" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Pierre Fons (Sanofi-Aventis, Toulouse, France)
"SAR106881, a fibroblast growth factor receptor agonist aimed at improving peripheral vascularization and wound healing and at reducing neuropathic pain" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Christoph Ladel (Merck Serono Research, Geneva, Switzerland)
"FGF18 evaluated in a translational dog model of osteoarthritis and relation to clinical settings" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:35 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| Afterwards: Introduction of an FGF website by Tomoko Iwata |
7:35 pm - 9:30 pm | FGFs in Cancer |
| Discussion Leader: Judith Abraham (Novartis Institutes for BioMedical Research, Emeryville, USA) |
7:30 pm - 7:55 pm | Fen Wang (Texas A&M Health Science Center, Houston, USA)
"The FGF signaling axis in prostate development and tumorigenesis" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:20 pm | Pamela Pollock (The Translational Genomics Research Institute, Phoenix, USA)
"FGFR2 in endometrial cancer - receptor activation, inhibition and resistance to FGFR tyrosine kinase inhibitors" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:35 pm | Tomoko Iwata (University of Glasgow, UK)
"Towards the mouse model of bladder cancer with FGFR3 mutations; co-operators and tissue-specific signaling" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Jing Qing (Genentech Inc., South San Francisco, USA)
"Antibody targeting of FGFR3 in human cancer" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Adam Cheuk (NIH/NCI, Bethesda, USA)
"Activating mutations of FGFR4 in rhabdomyosarcoma" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |