SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote and Emerging/Hot Topics |
| Discussion Leader: Sabine Werner (ETH Zürich, Switzerland) |
7:40 pm - 7:55 pm | Duncan Sparrow (Victor Chang Cardiac Research Centre, Syndey, Australia)
"A mechanism for gene-environment interaction in the etiology of congenital scoliosis"
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7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:20 pm | Zamal Ahmed (M D Anderson Cancer Centre, Houston, USA)
"Grb2 controls phosphorylation of FGF receptor by regulating kinase and Shp2 phosphatase activity"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Keynote: Michael Brand (Technische Universität Dresden, Germany)
"Biophysical aspects of Fgf8 signaling in vivo" |
9:10 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FGFs, FGFRs and the extracellular environment |
| Discussion Leader: David Ornitz (Washington University School of Medicine, USA) |
9:00 am - 9:25 am | Moosa Mohammadi (New York University School of Medicine, USA)
"A Novel Mode of FGF Receptor Dimerization" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Ellen Haugsten (The Norwegian Radiumhospital, Oslo, Norway)
"Clathrin- and dynamin-independent endocytosis of FGFR3 - implications for signaling"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Chiara Francavilla (University of Copenhagen(NNF CPR), Denmark)
"Proteomic characterization of the molecular switch underlying FGFR2IIIb recycling"
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10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 10:45 am | Diego Garcia-Gonzalez (Hospital Nacional de Parapléjicos, Spain)
"Anosmin-1 over-expression produces impaired olfactory function and congruent neuroanatomical changes in mice"
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10:45 am - 10:50 am | Discussion |
10:50 am - 11:00 am | Toru Imamura (Biomedical Research Institute, AIST, Tsukuba, Japan)
"Sulfated Glycosaminoglycans Are Required for Specific and Sensitive Fibroblast Growth Factor (FGF) 19 Signaling"
|
11:00 am - 11:05 am | Discussion |
11:05 am - 11:30 am | David Fernig (Liverpool University, UK)
"Exploring the Matrix with FGFs" |
11:30 am - 11:40 am | Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | FGF signaling pathways |
| Discussion Leader: David Fernig (Liverpool University, UK) |
5:30 pm - 5:55 pm | Michael Tsang (University of Pittsburgh, USA)
"Chemical approaches to dissecting the role of FGF signaling in heart development and regeneration" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:15 pm | Catherine Degnin (Shriners Research Center, Portland, USA)
"FGFR3 in the nucleus: mechanisms to generate the unexpected"
|
6:15 pm - 6:20 pm | Discussion |
6:20 pm - 6:30 pm | Pavel Krejci (Masaryk University Brno, Czech Republic & Cedars-Sinai Medical Center, Los Angeles, USA)
"Fibroblast growth factor upregulates Wnt/beta-catenin signaling via Erk MAP kinase/Lrp6 pathway"
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6:30 pm - 6:35 pm | Discussion |
6:35 pm - 6:45 pm | Frederick Tan (California Institute of Technology, Pasadena, California, USA)
"FGF/Erk MAP kinase signaling targets Nanog mRNA for degradation"
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6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Xin Zhang (Indiana University School of Medicine, USA)
"Genetic analysis of FGF signaling in eye development"
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7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Endocrine FGFs |
| Discussion Leader: Nobuyuki Itoh (Kyoto University, Japan) |
9:00 am - 9:25 am | Steven Kliewer (UT Southwestern Medical Center, USA)
"Metabolic Actions of Endocrine FGFs 15/19 and 21" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Christian Faul (University of Miami Miller School of Medicine, USA)
"Fibroblast Growth Factor 23 induces Left Ventricular Hypertrophy"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Tarja Kinnunen (University of Liverpool, UK)
"Control of metabolic physiology by FGFR/Klotho signalling is evolutionarily conserved"
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10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:00 am | Alexei Kharitonenkov (Lilly Research Laboratories, USA)
"Novel approaches to target FGF21 pathway" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:20 am | Junichiro Sonoda (Genentech, Inc., South San Francisco, USA)
"Antibody based approach to study the role of FGFR1 in adult mice"
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11:20 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Yang Li (Amgen, Inc., USA)
"Novel approaches to targeting the FGF21 pathway" |
11:50 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I (continued) |
5:30 pm - 7:30 pm | FGFs in genetic disease, humans and models |
| Discussion Leader: Fen Wang (Texas A&M Health Science Center, USA) |
5:30 pm - 5:55 pm | Marja Hurley (University of Connecticut, USA)
"Nuclear Isoforms and Bone Matrix Mineralization" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:15 pm | Rachel Liao (Harvard Graduate School of Arts and Sciences, USA)
"FGFR2 and FGFR3 as therapeutic targets in squamous cell lung carcinoma"
|
6:15 pm - 6:20 pm | Discussion |
6:20 pm - 6:30 pm | Sachiko Iseki (Tokyo Medical and Dental University, Japan)
"Opposing effects of FGF18 and FGF2 on developing cranial bones by different influences on Fgfr, Twist1 and Bmp expression"
|
6:30 pm - 6:35 pm | Discussion |
6:35 pm - 6:45 pm | Irma Thesleff (Institute of Biotechnology, University of Helsinki, Finland)
"Stem cells expressing Sox2 and regulated by FGFs contribute to all epithelial cell lineages in teeth"
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6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Nelly Pitteloud (Université de Lausanne, Switzerland)
"FGF21: a link between metabolism and reproduction"
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7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FGFs in growth control and cancer |
| Discussion Leader: Marja Hurley (University of Connecticut, USA) |
9:00 am - 9:25 am | Tomoko Iwata (Glasgow University, UK)
"Bladder cancer and the FGF signalling network" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Richard Grose (Barts Cancer Institute, Queen Mary University London, London, UK)
"FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior"
|
9:45 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Elaine Kilgour (AstraZeneca Oncology Innovative Medicines, Macclesfield, UK)
"AZD4547, a potent and selective FGF-receptor inhibitor, induces tumour regressions in human primary explant models of FGF-receptor amplified gastric cancer and squamous NSCLC"
|
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:00 am | Pamela Pollock (Queensland University of Technology, Australia)
"FGFR inhibition and the issues of intrinsic and acquired resistance" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:20 am | Fen Wang (Texas A&M Health Science Center, Houston, TX, USA)
"FGF signaling in prostate stem cells and prostate cancer"
|
11:20 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Ana Costa-Pereira (Imperial College London, UK)
"JAKs and STATs in FGF-2-mediated drug resistance" |
11:50 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | FGFs and organization of development |
| Discussion Leader: Irma Thesleff (University of Helsinki, Finland) |
5:30 pm - 5:55 pm | Mark Lewandoski (NCI-Frederick, NIH, USA)
"Diverse roles of Fibroblast Growth Factor signaling during somitogenesis and axis extension" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:15 pm | Matt Hoffman (NIDCR, NIH, Bethesda,USA)
"The self-renewal of epithelial progenitors during organogenesis requires Kit and Fgfr2b signaling"
|
6:15 pm - 6:20 pm | Discussion |
6:20 pm - 6:30 pm | Raj Ladher (RIKEN CDB, Kobe, Japan)
"Fibroblast Growth Factor Receptor 1 (FGFR1) controls intraflagellar transport in inner ear hair cell kinocilia"
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6:30 pm - 6:35 pm | Discussion |
6:35 pm - 6:45 pm | Sunday Oladipupo (Washington University School of Medicine, USA)
"FGF Receptor signaling is dispensable for normal vascular development, but is required for vascular response to injury and tumorigenesis"
|
6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Saverio Bellusci (Justus-Liebig-Universität, Germany)
"Role of FGF signaling in mesenchymal lineage commitment during lung development and after injury"
|
7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | FGFs in the nervous system |
| Discussion Leader: Saverio Bellusci (Justus-Liebig-Universität, Germany) |
9:00 am - 9:25 am | Albert Basson (King's College London, UK)
"The importance of regulating FGF signals during development of the cerebellum" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Ing-Ming Chiu (National Health Research Institutes, Miaoli, Taiwan)
"Expression pattern of GFP driven by FGF1 promoter in F1B-GFP transgenic mice"
|
9:45 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Sophie Thompson (University of Liverpool, UK)
"Remodelling of heparan sulfate by 6-O-sulfatases regulates fibroblast growth factor induced astrocytosis and glial cell boundary formation"
|
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:00 am | Hisashi Umemori (University of Michigan, USA)
"FGF and Synapse Formation" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:20 am | Olga Baron (Hannover Medical School, Hannover, Germany)
"Contributory regulation of ventral mesencephalic dopaminergic neuron development by FGF-2"
|
11:20 am - 11:25 am | Discussion |
11:25 am - 11:50 am | David Ornitz (Washington University School of Medicine, USA)
"In vivo regulation of progenitor cell lineages by the FGF9/16/20 family" |
11:50 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II (continued) |
5:30 pm - 7:30 pm | FGF signaling in repair, regeneration and therapeutics |
| Discussion Leader: Brad Olwin (University of Colorado, USA) |
5:30 pm - 5:50 pm | Sabine Werner (ETH Zürich, Switzerland)
"Mechanisms of FGF action in repair of epithelial tissues" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Stijn De Langhe (National Jewish Health, USA)
"Lung stem cells and their niche"
|
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Lars Klimaschewski (Medical University Innsbruck, Innsbruck, Austria)
"FGF-dependent signaling in sensory neurons: Novel approaches to accelerate peripheral axon regeneration"
|
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 6:55 pm | Simon Woehrle (Novartis Institutes for BioMedical Research, Basel, Switzerland)
"FGFR inhibitors as a targeted therapy for FGF23-related hypophosphatemia disorders"
|
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Christoph Ladel (Merck Serono Research, Germany)
"FGF18 as specific growth factor for cartilage repair in preclinical and clinical cartilage disorders" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |