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Fibroblast Growth Factors in Development and Disease

Gordon Research Conference

FGF Signalling: From Molecular Understanding to Therapeutic Targeting

June 5 - 10, 2016
Chairs Richard P. Grose and Anne-Karina Perl
Vice Chair Marja Hurley

Conference Description

This conference will cover the most recent and exciting research in all aspects of FGF biology, facilitating interdisciplinary interactions between scientists and clinicians working in academia and industry. The topics are organized such that this meeting will address FGF signaling from its most fundamental biochemistry through its fundamental roles in development, homeostasis, repair and disease, culminating in a session on the most recent therapeutic advances relating to the clinical significance of FGF signalling. In addition to presentations by invited speakers, abstracts will be selected for shorter oral presentation for each session. Applications will be accepted from established investigators, junior PIs, postdocs and graduate students. This meeting is preceded by a satellite GRS meeting designed for postdocs and graduate students prior to the main GRC meeting.

Related Meeting

This GRC will be held in conjunction with the "Fibroblast Growth Factors in Development and Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Mechanistic Basis of Pathological FGFR Signal Transduction
Discussion Leader: Richard Grose (Queen Mary University of London, United Kingdom)
7:40 pm - 8:15 pmJohn Ladbury (University of Leeds, United Kingdom)
"Oncogenic FGFR Signalling in the Absence of Kinase Up-Regulation"
8:15 pm - 8:35 pmDiscussion
8:35 pm - 9:10 pmPhilippe Soriano (Icahn School of Medicine at Mount Sinai, USA)
"FGF Signaling Pathways in Development"
9:10 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFGFR Signaling
Discussion Leaders: Sabine Werner (ETH Zurich, Switzerland) and Ellen Margrethe Haugsten (The Norwegian Radium Hospital, Norway)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amChiara Francavilla (University of Manchester, United Kingdom)
"Functional Proteomics of FGF Signaling"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amAlvaro Ingles-Prieto (Institute of Science and Technology Austria, Austria)
"Bringing Light to Receptors with LOV"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amAntoni Wiedlocha (Institute for Cancer Research, Oslo University Hospital, Norway)
"Proteomic Mapping Reveals Molecular Determinants of FGF Receptor Signalling and Trafficking"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:20 amMoosa Mohammadi (NYU Langone Medical Center, USA)
"Molecular Determinants of FGF Signaling Specificity"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJin-San Zhang (Wenzhou Medical University, China)
"Integration of Genomics, Proteomics and Optogenetic Tools in Dissecting the FGFFRs' Signaling Network in Cancer Stem Cell and Precision Medicine"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmTatjana Piotrowski (Stowers Institute for Medical Research, USA)
"FGF Signaling in Sensory Hair Cell Development and Regeneration"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEndocrine FGFs / FGFs and Matrix Interactions
Discussion Leaders: Jeremy Turnbull (University of Liverpool, United Kingdom) and Aiseta Baradji (University of Liverpool, United Kingdom)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmDave Fernig (University of Liverpool, United Kingdom)
"FGFs and Heparan Sulfate: When Sugars Are Good for You"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmVeronika Stepankova (Masaryk University, Czech Republic)
"Computer-Assisted Engineering of Hyperstable Fibroblast Growth Factor 2"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBeate Lanske (Harvard School of Dental Medicine, USA)
"FGF23 and Its Targets"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmYang Li (Amgen Inc., USA)
"Endocrine FGFs: Metabolic Action and Therapeutic Development"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDevelopmental Models
Discussion Leaders: Saverio Bellusci (Justus-Liebig-University Giessen, Germany) and Otto Makela (University of Helsinki, Finland)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amSuzanne Mansour (University of Utah, USA)
"FGF Signaling in Inner Ear Development and Hearing Loss"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amKathy Schall (Children's Hospital Los Angeles, USA)
"FGF Signaling in Intestinal Homeostasis, Injury and Adaptation"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amSung-Ho Huh (University of Nebraska Medical Center, USA)
"Regulation of Sensory Progenitor Cells Through Fibroblast Growth Factor Signaling"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amDavid Ornitz (Washington University in St. Louis, USA)
"Fibroblast Growth Factors: Critical Regulators of Osteogenic and Chondrogenic Growth Programs"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amXin Zhang (Columbia University, USA)
"Control of Epithelial Cell Shape by FGF Signaling in Lens Development"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMohammad Hajihosseini (University of East Anglia, United Kingdom)
"FGF10 – A Regulator of Neurogenesis in Multiple Regions of Postnatal Brain"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
2:00 pm - 4:00 pmPoster Session
4:00 pm - 6:00 pmDevelopment and Disease
Discussion Leaders: Anne-Karina Perl (Cincinnati Children's Hospital, USA) and Cho-Ming Chao (Justus Liebig University Giessen, Germany)
4:00 pm - 4:15 pmIntroduction by Discussion Leader
4:15 pm - 4:35 pmDuncan Sparrow (University of Oxford, United Kingdom)
"Hypoxia Disrupts Embryonic Heart Development by Specific Inhibition of FGF Signaling"
4:35 pm - 4:45 pmDiscussion
4:45 pm - 5:05 pmSaverio Bellusci (Justus-Liebig-University Giessen, Germany)
"Novel Roles for Fibroblast Growth Factor 10 During Lung Development and Injury"
5:05 pm - 5:15 pmDiscussion
5:15 pm - 5:35 pmJennifer Symonds (National Institute of Dental and Craniofacial Research, NIH, USA)
"Role of Fibroblast Growth Factor Receptors in Progenitor Populations During Salivary Gland Development"
5:35 pm - 5:45 pmDiscussion
5:45 pm - 5:55 pmStacey House (Washington University School of Medicine, USA)
"FGF Signaling in Cardiac Ischemia-Reperfusion Injury and Repair"
5:55 pm - 6:00 pmDiscussion
6:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegeneration and Repair
Discussion Leaders: Michael Meyer (ETH Zurich, Switzerland) and Xiaojie Wang (Wenzhou Medical University, China)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amLin Chen (Third Military Medical University, China)
"FGF Signaling in Cartilage Maintenance"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amRegina Irschick (Medical University of Innsbruck, Austria)
"Regulation of FGFR1 Trafficking by Sprouty2 in Human Glioma Cells"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amSonglin Li (Wenzhou University, China)
"Post-Stroke Axonal Sprouting and Growth-Associated Factors"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amLuigi Maddaluno (ETH Zurich, Switzerland)
"FGF-Cytokine Crosstalk in Skin Homeostasis and Disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amBradley Olwin (University of Colorado, USA)
"FGR1 Signaling in Muscle Stem Cell Function During Aging"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmJeremy Turnbull (University of Liverpool, United Kingdom)
"Chemical Biology Tools to Elucidate Selective Regulation of Signalling by FGF-FGFR Pairings"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic Diseases
Discussion Leaders: Marja Hurley (University of Connecticut, USA) and Andrew Hagan (Washington University School of Medicine, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmStefan Bagheri-Fam (Hudson Institute of Medical Research, Australia)
"FGF9, FGFR2 and Sex Reversal Syndromes"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmLaurence Legeai-Mallet (Institut Imagine / INSERM U1163, France)
"FGFR3 and Osteochondrodysplasias"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmAmy Merrill-Brugger (University of Southern California, USA)
"FGFR2 in Heritable Disorders of Connective Tissue"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmYoshikazu Nakamura (Ribomic Inc., Japan)
"Dual Therapeutic Action of a Neutralizing Anti-FGF2 Aptamer in Bone Diseases and Bone Cancer Pain"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmCancer
Discussion Leaders: Abbie Fearon (ETH Zürich, Switzerland) and Malgorzata Zakrzewska (University of Wroclaw, Poland)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amTomoko Betsuyaku (Keio University School of Medicine, Japan)
"Diverse Roles of FGF9 in Lung Cancer"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amPamela Pollock (Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia)
"Targeting FGFR2 in Endometrial Cancer"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amNatasha Clayton (Barts Cancer Institute, Queen Mary University of London, United Kingdom)
"PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase Driven Cancer"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amDina Ron (Technion - Israel Institute of Technology, Israel)
"Sef (Similar Expression to FGF) Is a New Modulator of Epitheliogenesis and Epithelial Neoplasia"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amFen Wang (Texas A&M Health Science Center, USA)
"Aberrant FGF Signaling in Cancer Cell Metabolism"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAgi Grigoriadis (King's College London, United Kingdom)
"Targeting FGFR Signalling in Osteosarcoma Pathogenesis and Metastasis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmNovel Therapeutics and Clinical Trials
Discussion Leaders: Michael Seckl (Imperial College London, United Kingdom) and Anne Gigout (Merck, Germany)
4:00 pm - 4:15 pmIntroduction by Discussion Leader
4:15 pm - 4:35 pmMatilda Katan (University College London, United Kingdom)
"Landscape of Activating Cancer Mutations in FGFR Kinases and Their Differential Responses to Inhibitors in Clinical Use"
4:35 pm - 4:45 pmDiscussion
4:45 pm - 5:05 pmIng-Ming Chiu (National Health Research Institutes, Taiwan)
"Activation of Aurora A Kinase Through the FGF1/FGFR Signaling Axis Sustains the Stem Cell Characteristics of Glioblastoma Cells"
5:05 pm - 5:15 pmDiscussion
5:15 pm - 5:25 pmBenjamin Almquist (Imperial College London, United Kingdom)
"Nanotechnology-Based Strategies for Manipulating Growth Factor Signalling"
5:25 pm - 5:30 pmDiscussion
5:30 pm - 5:50 pmChao Jiang (The Wenzhou Medical University, China)
"Development of Fibroblast Growth Factors as Pharmaceuticals in China"
5:50 pm - 6:00 pmDiscussion
6:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Contributors

Conference Links

Conference History Fibroblast Growth Factors in Development and Disease (GRS)
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