Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Endocrine FGF Signaling, Intracrine FGFs and Insights in FGFR Biology Using Optogenetics
Discussion Leaders: Marja Hurley (University of Connecticut, USA) and Pamela Pollock (Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia)
7:40 pm - 8:00 pm
Steve Kliewer (University of Texas Southwestern Medical Center, USA)
"Metabolic Stress Hormone FGF21: From Thirsty to Thin"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Fernanda Laezza (University of Texas Medical Branch, USA)
"Pharmacology of Intracellular FGFs for CNS Drug Discovery"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Harald Janovjak (Australian Regenerative Medicine Institute, Monash University / EMBL Australia, Australia)
"Optical Control of Growth Factor Signals"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
FGF Signaling in Early Development
Discussion Leaders: Cho-Ming Chao (Justus Liebig University Giessen, Germany) and Moosa Mohammadi (NYU Langone Medical Center, USA)
9:00 am - 9:20 am
Philippe Soriano (Icahn School of Medicine at Mount Sinai, USA)
"FGF Signalling in Craniofacial Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Anna-Katerina Hadjantonakis (Memorial Sloan Kettering Cancer Center, USA)
"The Role of FGF Signalling in Cell Fate Specification in the Mouse Blastocyst"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Francesca Rochais (UMR_S910, INSERM / Aix-Marseille University, France)
"Role of FGF10 in Cardiac Development and Regeneration"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Ophir Klein (University of California, San Francisco, USA)
"Feedback Regulators of FGF Signalling in Craniofacial Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Suzanne Mansour (University of Utah, USA)
"FGF Signalling in Inner Ear Development and Function"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Mina Mina (University of Connecticut Health Center, USA)
"Effects of FGF Signalling on the Fate of ASMA+ Mesenchymal Stem Cells in Dental Pulp"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Mark Lewandoski (National Cancer Institute, NIH, USA)
"FGF Signaling Interactions with the Pro-Apoptotic Machinery During Development"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Helen Makarenkova (The Scripps Research Institute, USA)
"Analysis of FGF10-Expressing Cells During Submandibular Gland Postnatal Development"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Pamela Pollock (Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
FGF Signaling in Organogenesis
Discussion Leaders: Kel Vin Woo (Washington University in St. Louis, USA) and Xin Zhang (Columbia University, USA)
7:30 pm - 7:50 pm
Sabine Werner (ETH Zurich, Switzerland)
"Control of Epithelial Integrity and Repair by FGFs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Abigail Tucker (King's College London, United Kingdom)
"FGF10 in Cranial Glands: From Development to Regeneration"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Tatjana Piotrowski (Stowers Institute for Medical Research, USA)
"The Role of Fgf Signaling in Sensory Hair Cell Regeneration"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Nan Tang (National Institute of Biological Sciences, Beijing, China)
"Fgf10 Functions as a Local Chemoattractant Factor that Is Essential for Pulmonary Alveolar Epithelial Cell Fate Specification"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Saverio Bellusci (Justus Liebig University Giessen, Germany)
"Role of Fgf10 on Alveolar Epithelial Lineage Formation"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
FGFs/FGFRs in Neural Development and Disease
Discussion Leaders: Fernanda Laezza (University of Texas Medical Branch, USA) and Stuart Nayar (University of East Anglia, United Kingdom)
9:00 am - 9:20 am
Jean Hebert (Albert Einstein College of Medicine, USA)
"Distinct FGFR Function Depending on the Adult Neural Stem Cell Niche"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Rashmi Bansal (Univ of Connecticut Medical School, USA)
"Regulation of Myelin Biogenesis and Maintenance by FGF and ERK-MAPK Signalling in Myelinating Glial Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Erwin Pauws (UCL Great Ormond Street Institute of Child Health, United Kingdom)
"Exploring the Role of FGFR2 in Craniofacial Birth Defect"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Benediktas Kaminskas (University of East Anglia, United Kingdom)
"In Vivo Regulation of Postnatal Hypothalamic Neurogenesis by Fibroblast Growth Factor (FGF) Signalling"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Lu Yang (Washington University School of Medicine, USA)
"A Fibroblast Growth Factor 20-Expressing, Wnt-Responsive Progenitor Populates the Olfactory Epithelium and Regulates Turbinate Growth"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Maxence Cornille (Institut Imagine (UMR 1163), INSERM, France)
"Fgfr3A385E/+ Mouse Model for Crouzon Syndrome with Acanthosis Nigricans Exhibits Skull Development Anomalies and Behavior Abnormalities"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Geoffrey Pitt (Weill Cornell Medicine, USA)
"FGF13 and Obesity"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Luke Noon (Consorcio Centro de Investigación Biomédica en Red, M.P. (CIBER), Spain)
"Impaired Fgf-7 Signaling in the Insulin Resistant Liver: Implications for Chronic Injury-Repair and De Novo Hepatogenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
FGFs/FGFRs in Musculoskeletal Biology
Discussion Leaders: Laurence Legeai-Mallet (Institut Imagine, INSERM U1163, France) and Thomas Doetschman (University of Arizona, USA)
7:30 pm - 7:50 pm
David Ornitz (Washington University in St. Louis, USA)
"Regulation of Bone Growth by FGF Receptor Signalling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Yoshikazu Nakamura (RIBOMIC Inc., Japan)
"Anti-FGF2 Aptamer Provides Novel Therapies for Achondroplasia and Age-Related Macular Degeneration"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Liping Xiao (UConn Health, USA)
"FGF23 Neutralizing Antibody Partially Improves Bone Mineralization Defect of HMWFGF2 Isoforms Transgenic Female Mice"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Amy Merrill-Brugger (University of Southern California, USA)
"The Role of FGF Signaling in Patterning the Tendon-Bone Interface"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Michaela Bosakova (Masaryk University, Czech Republic)
"Regulation of Ciliary Function by Fibroblast Growth Factor Signaling Identifies FGFR3-Related Disorders Achondroplasia and Thanatophoric Dysplasia as Ciliopathies"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Function of Endocrine and Intracellular FGFs
Discussion Leaders: David Ornitz (Washington University in St. Louis, USA) and Chiara Francavilla (University of Manchester, United Kingdom)
9:00 am - 9:20 am
Kenneth White (Indiana University School of Medicine, USA)
"Novel Regulatory Control of FGF23: Implications for Health and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Eleftheria Maratos-Flier (Beth Israel Deaconess Medical Center, Harvard Medical School, USA)
"Consensus and Controversies on FGF21 Action"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Cristal Hill (Pennington Biomedical Research Center, Louisiana State University, USA)
"Dietary Protein Restriction and FGF21 Signalling"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
Elissavet Kardami (University of Manitoba, Canada)
"FGF-2 Isoforms in Cardiac Stress-Induced Remodelling"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:25 am
Grethel Millington (University of Connecticut School of Dental Medicine, USA)
"High Molecular Weight FGF2 in Dentin and Alveolar Bone Mineralization"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Richard Grose (Queen Mary University of London, United Kingdom)
"Nuclear FGF Receptor and Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Jo El Schultz (University of Cincinnati College of Medicine, USA)
"HMWFGF2 Effects Relating to Ischemic Injury and Revascularization"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Role of FGFs/FGFRs in Tumorigenesis
Discussion Leaders: Saverio Bellusci (Justus Liebig University Giessen, Germany) and Stephanie Kainrath (Institute of Science and Technology Austria, Austria)
7:30 pm - 7:50 pm
Michael Ittmann (Baylor College of Medicine, USA)
"Targeting FGF Signalling in Prostate Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Kwok-Kin Wong (Perlmutter Cancer Center, NYU Langone Health, USA)
"Lung Cancer Gemms and Treatments"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Michael Seckl (Imperial College London, United Kingdom)
"How to Select Cancer Patients for FGFR Inhibitors, Laboratory and Clinical Clues"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Zamal Ahmed (University of Texas MD Anderson Cancer Center, USA)
"Multi-Functional Role of Adapter Protein Grb2 in Cellular Proliferation and DNA Damage Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Vanessa Bonazzi (Queensland University of Technology, Australia)
"Unforeseen Bone Toxicity with Combined In Vivo PI3K and FGFR Inhibition"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Research Areas in FGF Biology
Discussion Leaders: Benediktas Kaminskas (University of East Anglia, United Kingdom) and Suzanne Mansour (University of Utah, USA)
9:00 am - 9:20 am
Ellen Margrethe Haugsten (The Norwegian Radium Hospital, Norway)
"Using Proximity Labeling (Bioid and APEX) to Identify Determinants of FGFR Signalling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jin-San Zhang (Wenzhou Medical University, China)
"Recent Progress in Research and Therapeutic Application of FGFs in China"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Liisa Kuhn (University of Connecticut School of Dental Medicine, USA)
"FGF2 and Tissue Engineering"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Kel Vin Woo (Washington University in St. Louis, USA)
"Fibroblast Growth Factor Signaling Is Protective in Hypoxia-Induced Pulmonary Hypertension"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mohammad Hajihosseini (University of East Anglia, United Kingdom)
"Limb Defects in a Mouse Model of LADD Syndrome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Moosa Mohammadi (NYU Langone Medical Center, USA)
"α-Klotho Is a Non-Enzymatic Molecular Scaffold for FGF23 Hormone Signaling"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Dave Fernig (University of Liverpool, United Kingdom)
"Paracrine FGFs and Their Sugar Partners in Crime"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dynamics of FGF Signaling
Discussion Leaders: Philippe Soriano (Icahn School of Medicine at Mount Sinai, USA) and Abbie Fearon (ETH Zurich, Switzerland)
7:30 pm - 7:50 pm
Jeremy Turnbull (University of Liverpool, United Kingdom)
"Sulfation Code Hierarchies in HS Regulation of FGF Signalling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Tarja Kinnunen (University of Huddersfield, United Kingdom)
"FGF/HSPG Signalling in C. Elegans "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Pavel Krejci (Masaryk University, Czech Republic)
"Using Proteomics to Unravel the FGFR3 Interactome"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Jeffrey Stavenhagen (Therachon, Switzerland)
"Direct Targeting of the Molecular Pathway that Underlies Achondroplasia: Development of Soluble FGFR3 as a Drug"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Chiara Francavilla (University of Manchester, United Kingdom)
"A Proteomic Approach to Analyze Fibroblast Growth Factor Receptor (FGFR) Trafficking-Dependent Signaling Specificity"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure